Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Roshan Padmanabhan"'
Autor:
Haneen Yehya, Alexandra Wells, Michael Majcher, Dhruv Nakhwa, Ryan King, Faruk Senturk, Roshan Padmanabhan, Jan Jensen, Michael A. Bukys
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Background Type 1 diabetes, an autoimmune disorder leading to the destruction of pancreatic β-cells, requires lifelong insulin therapy. Islet transplantation offers a promising solution but faces challenges such as limited availability and
Externí odkaz:
https://doaj.org/article/5de5ed93cc004b8ebe83135ec58b7bd9
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Stem cell-derived therapies hold the potential for treatment of regenerative clinical indications. Static culture has a limited ability to scale up thus restricting its use. Suspension culturing can be used to produce target cells
Externí odkaz:
https://doaj.org/article/85bd865afc824aaeb64b634a62a22d86
Autor:
David R. Sweet, Roshan Padmanabhan, Xudong Liao, Himanshu R. Dashora, Xinmiao Tang, Lalitha Nayak, Rajan Jain, Sarah De Val, Vinesh Vinayachandran, Mukesh K. Jain
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 4 (2023)
Background Proper function of endothelial cells is critical for vascular integrity and organismal survival. Studies over the past 2 decades have identified 2 members of the KLF (Krüppel‐like factor) family of proteins, KLF2 and KLF4, as nodal regu
Externí odkaz:
https://doaj.org/article/eee23e7ab2c94a2e8302cd3fdf3f0c39
Autor:
Shyam K Poudel, Roshan Padmanabhan, Heloni Dave, Kathryn Guinta, Tyler Stevens, Madhusudhan R Sanaka, Prabhleen Chahal, Davendra P S Sohal, Alok A Khorana, Charis Eng
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283021 (2023)
BackgroundThe prognostic and pathophysiologic significance of the biliary microbiota in pancreaticobiliary malignancies is little understood. Our goal was to find malignancy-related microbiomic fingerprints in bile samples taken from patients with be
Externí odkaz:
https://doaj.org/article/2d617dcb1c63470cb21d52dc6468854f
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Targeted therapies for solid tumors in children, adolescents, and young adults (C-AYA) lag behind that of adult carcinomas. Here, the authors study the germline genomic signatures of 1,507 C-AYA patients with solid tumors and find pathogenic/likely p
Externí odkaz:
https://doaj.org/article/36633244b1ef47a0af16dac7729a6ae5
Autor:
Ted M. Getz, Gary Stuart Hoffman, Roshan Padmanabhan, Alexandra Villa-Forte, Eric E. Roselli, Eugene Blackstone, Douglas Johnston, Gosta Pettersson, Edward Soltesz, Lars G. Svensson, Leonard H. Calabrese, Alison H. Clifford, Charis Eng
Publikováno v:
Pathogens and Immunity, Vol 4, Iss 1, Pp 105-123 (2019)
Objective: We sought to characterize microbiomes of thoracic aortas from patients with non-infectious aortitis due to giant cell arteritis (GCA) and clinically isolated aortitis (CIA) and to compare them to non-inflammatory aorta aneurysm controls. W
Externí odkaz:
https://doaj.org/article/dacffb4099d34989b2fe4dd1ac82f9a3
Autor:
Gary Stuart Hoffman, Ted M. Getz, Roshan Padmanabhan, Alexandra Villa-Forte, Alison H. Clifford, Pauline Funchain, Madhav Sankunny, Julian D. Perry, Alexander Blandford, Gregory Kosmorsky, Lisa Lystad, Leonard H. Calabrese, Charis Eng
Publikováno v:
Pathogens and Immunity, Vol 4, Iss 1, Pp 21-38 (2019)
Objective: A role for microorganisms in giant cell arteritis (GCA) has long been suspected. We describe the microbiomes of temporal arteries from patients with GCA and controls. Methods: Temporal artery biopsies from patients suspected to have GCA w
Externí odkaz:
https://doaj.org/article/805cc8803ce340b6920a59a6dedecf35
Autor:
Rengasamy Palanivel, Vinesh Vinayachandran, Shyam Biswal, Jeffrey A. Deiuliis, Roshan Padmanabhan, Bongsoo Park, Roopesh Singh Gangwar, Jared C. Durieux, Elaine Ann Ebreo Cara, Lopa Das, Graham Bevan, Zahi A. Fayad, Ahmed Tawakol, Mukesh K. Jain, Sujata Rao, Sanjay Rajagopalan
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101728- (2020)
Summary: Particulate matter ≤2.5μm (PM2.5) air pollution is a leading environmental risk factor contributing disproportionately to the global burden of non-communicable disease. We compared impact of chronic exposure to PM2.5 alone, or with light
Externí odkaz:
https://doaj.org/article/ee1b915295be4d6b92fb5c3734b768fc
Autor:
Simon Nicolas, Vincent Blasco‐Baque, Audren Fournel, Jerome Gilleron, Pascale Klopp, Aurelie Waget, Franck Ceppo, Alysson Marlin, Roshan Padmanabhan, Jason S Iacovoni, François Tercé, Patrice D Cani, Jean‐François Tanti, Remy Burcelin, Claude Knauf, Mireille Cormont, Matteo Serino
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 3, Pp 1-17 (2017)
Abstract Gut microbiota dysbiosis has been implicated in a variety of systemic disorders, notably metabolic diseases including obesity and impaired liver function, but the underlying mechanisms are uncertain. To investigate this question, we transfer
Externí odkaz:
https://doaj.org/article/b955560a33e845d1b23e5d096d6e2b27
Autor:
Satishchandra Parthasarathy, Mahadevan Anita, Anand Krishnamurthy, Roshan Padmanabhan, Mahendarkar Aruna V, Mangaiarkarasi Asokan, Siddappa Nagadenahalli B, Dash Prasanta K, Shankar Susarla K, Prasad Vinayaka R, Ranga Udaykumar
Publikováno v:
Retrovirology, Vol 5, Iss 1, p 25 (2008)
Abstract Background The pathogenic significance of coreceptor switch in the viral infection of HIV-1 is not completely understood. This situation is more complex in subtype C infection where coreceptor switch is either absent or extremely rare. To ga
Externí odkaz:
https://doaj.org/article/d4d57162197d4851aa9c1aa4a02a8e03