Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Roshan Liyanage"'
Autor:
Nalaka Wijekoon, Lakmal Gonawala, Pyara Ratnayake, Roshan Liyanage, Dhammika Amaratunga, Yetrib Hathout, Harry W. M. Steinbusch, Ashwin Dalal, Eric P. Hoffman, K. Ranil D. de Silva
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-16 (2024)
Abstract Background The phenotype of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) patients is determined by the type of DMD gene variation, its location, effect on reading frame, and its size. The primary objective of this in
Externí odkaz:
https://doaj.org/article/c4163d83d1134daf81f028ae6456712e
Autor:
Nalaka Wijekoon, Lakmal Gonawala, Pyara Ratnayake, Pulasthi Dissanayaka, Isuru Gunarathne, Dhammika Amaratunga, Roshan Liyanage, Sunethra Senanayaka, Saraji Wijesekara, Hemal H. Gunasekara, Kamala Vanarsa, Jessica Castillo, Yetrib Hathout, Ashwin Dalal, Harry W.M. Steinbusch, Eric Hoffman, Chandra Mohan, K. Ranil D. de Silva
Publikováno v:
Heliyon, Vol 9, Iss 8, Pp e18530- (2023)
Introduction: Documented Duchenne Muscular Dystrophy (DMD) biomarkers are confined to Caucasians and are poor indicators of cognitive difficulties and neuropsychological alterations. Materials and methods: This study correlates serum protein signatur
Externí odkaz:
https://doaj.org/article/ea7f989c48ed46f8ad872ba9e802e1d3
Autor:
Vidadi Yusibov, Mangala Roshan Liyanage, Jessica A. Chichester, C. Russell Middaugh, Yoko Shoji, Vidyashankara Iyer, Sangeeta B. Joshi, R. Mark Jones
Publikováno v:
Human Vaccines & Immunotherapeutics. 8:453-464
Influenza is a prevalent, highly contagious and sometimes fatal respiratory disease. Vaccination provides an effective approach to control the disease, but because of frequent changes in the structure of the major surface proteins, there is great nee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f25469b7264c8c47b977215f318a66
https://doi.org/10.4161/hv.19106
https://doi.org/10.4161/hv.19106
Publikováno v:
Protein Science. 17:555-562
The Ca2+ signaling protein calmodulin (CaM) stimulates Ca2+ pumping in the plasma-membrane Ca2+-ATPase (PMCA) by binding to an autoinhibitory domain, which then dissociates from the catalytic domain of PMCA to allow full activation of the enzyme. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f060e1d93a23c796480271c19f6adf3c
https://doi.org/10.1110/ps.073239108
https://doi.org/10.1110/ps.073239108
Publikováno v:
The Journal of Physical Chemistry B. 111:5494-5502
It has long been recognized that the fluorescence lifetimes of amino acid residues such as tyrosine and tryptophan depend on the rotameric configuration of the aromatic side chain, but estimates of the rate of interchange of rotameric states have var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b9c460293f26b70e0b4bcfc8b91de8
https://doi.org/10.1021/jp0645059
https://doi.org/10.1021/jp0645059
Publikováno v:
Methods in Molecular Biology ISBN: 9781627036726
In peptides, steady-state fluorescence can be used to measure the intrinsic fluorescence of Trp, Tyr, and Phe residues, as well as associated dyes, which can change upon exposure to different environmental conditions. This technique can be thus used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d74026561cd0d90bab6186f2a684f210
https://doi.org/10.1007/978-1-62703-673-3_16
https://doi.org/10.1007/978-1-62703-673-3_16
Publikováno v:
Methods in Molecular Biology ISBN: 9781627036726
UV absorption spectroscopy is commonly used with peptides for determining concentration and enzyme activity, but high-resolution UV spectra can also provide information on peptide secondary and tertiary structure and association behavior. New develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3866a52ef3f919ab52c002f721fc1a73
https://doi.org/10.1007/978-1-62703-673-3_15
https://doi.org/10.1007/978-1-62703-673-3_15
Publikováno v:
Methods in Molecular Biology ISBN: 9781627036726
Circular dichroism measures the difference between the absorbance of left- and right-handed circularly polarized light, and can be used to monitor the secondary structure of peptides (far UV) and the tertiary structure of larger polypeptides (near UV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c5a369125e31377fd3044478b9c058d
https://doi.org/10.1007/978-1-62703-673-3_17
https://doi.org/10.1007/978-1-62703-673-3_17
Publikováno v:
Methods in Molecular Biology ISBN: 9781627036726
Fourier transform infrared (FTIR) spectroscopy provides data that are widely used for secondary structure characterization of peptides. A wide array of available sampling methods permits structural analysis of peptides in diverse environments such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::886dc367842dde52c5035f96e98064dd
https://doi.org/10.1007/978-1-62703-673-3_18
https://doi.org/10.1007/978-1-62703-673-3_18
Autor:
Reza Esfandiary, David B. Volkin, Jeff Maisonneuve, Vidyashankara Iyer, Mangala Roshan Liyanage, Sangeeta B. Joshi, Andreas Meinke, Lei Hu, Christoph Reinisch, C. Russell Middaugh
Publikováno v:
Journal of pharmaceutical sciences. 101(9)
The preformulation of a trivalent recombinant protein-based vaccine candidate for protection against Streptococcus pneumoniae is described both in the presence and in the absence of aluminum salt adjuvants. The biophysical properties of the three pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eafe41e82519e374062a323393dbdf3
https://pubmed.ncbi.nlm.nih.gov/22538529
https://pubmed.ncbi.nlm.nih.gov/22538529