Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Roshan L. Shrestha"'
Autor:
Bruna R. Muys, Roshan L. Shrestha, Dimitrios G. Anastasakis, Lorinc Pongor, Xiao Ling Li, Ioannis Grammatikakis, Ahsan Polash, Raj Chari, Myriam Gorospe, Curtis C. Harris, Mirit I. Aladjem, Munira A. Basrai, Markus Hafner, Ashish Lal
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112260- (2023)
Summary: Matrin3 is an RNA-binding protein that regulates diverse RNA-related processes, including mRNA splicing. Although Matrin3 has been intensively studied in neurodegenerative diseases, its function in cancer remains unclear. Here, we report Mat
Externí odkaz:
https://doaj.org/article/a88f2d3b066a45a5bbb59f4426f60a4b
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Chromosome instability frequently occurs due to issues with chromosome-microtubule attachments. Here the authors show that the Astrin-PP1 and Cyclin-B-CDK1 pathways counteract each other to protect chromosome-microtubule attachments independent of bi
Externí odkaz:
https://doaj.org/article/9a8bb329ba4246098107250f4606529c
Autor:
Roshan L. Shrestha, Duccio Conti, Naoka Tamura, Dominique Braun, Revathy A. Ramalingam, Konstanty Cieslinski, Jonas Ries, Viji M. Draviam
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Human chromosomes are captured along microtubule walls and then tethered to microtubule-ends through a multi-step end-on conversion process. Here the authors show that Aurora-B regulates end-on conversion in human cells and establish a late role for
Externí odkaz:
https://doaj.org/article/f9f5bd0b1aa64801bac6724611b10ea2
Publikováno v:
Open Biology, Vol 4, Iss 6 (2014)
Chromosomal instability can arise from defects in chromosome–microtubule attachment. Using a variety of drug treatments, we show that TAO1 kinase is required for ensuring the normal congression of chromosomes. Depletion of TAO1 reduces the density
Externí odkaz:
https://doaj.org/article/61bb1f90078d4b208b28003bda7fd33c
Autor:
Roshan L. Shrestha, Vinutha Balachandra, Jee Hun Kim, Austin Rossi, Pranathi Vadlamani, Subhash Chandra Sethi, Laurent Ozbun, Shinjen Lin, Ken Chin-Chien Cheng, Raj Chari, Tatiana S. Karpova, Gianluca Pegoraro, Daniel R. Foltz, Natasha J. Caplen, Munira A. Basrai
Publikováno v:
Journal of Cell Science. 136
Restricting the localization of the evolutionarily conserved centromeric histone H3 variant CENP-A to centromeres prevents chromosomal instability (CIN). The mislocalization of CENP-A to non-centromeric regions contributes to CIN in yeasts, flies and
Autor:
Corrine Corrina R. Hartford, Roshan L. Shrestha, Lorinc Pongor, Yongmei Zhao, Xiongfong Chen, Caroline Fromont, Ritu Chaudhary, Xiao Ling Li, Katherine R. Pasterczyk, Ravi Kumar, Bruna R. Muys, Dimitrios Tsitsipatis, Raj Chari, Myriam Gorospe, Mirit I. Aladjem, Javed Khan, Munira A. Basrai, Ioannis Grammatikakis, Ashish Lal
Publikováno v:
Mol Cell Biol
PURPL is a p53-induced lncRNA that suppresses basal p53 levels. Here, we investigated PURPL upon p53 activation in liver cancer cells, where it is expressed at significantly higher levels than other cell types. Using isoform sequencing, we discovered
Autor:
Bruna R. Muys, Roshan L. Shrestha, Dimitrios G. Anastasakis, Lorinc Pongor, Xiao Ling Li, Ioannis Grammatikakis, Ahsan Polash, Curtis C Harris, Mirit I. Aladjem, Munira A. Basrai, Markus Hafner, Ashish Lal
Matrin3 is an RNA-binding protein that affects diverse RNA-related processes, including mRNA splicing. While Matrin3 has been intensively studied in neurodegenerative diseases, its function in cancer remains unclear. Here, we discovered Matrin3-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4282be56d5634789167229bff77db251
https://doi.org/10.1101/2022.06.08.495349
https://doi.org/10.1101/2022.06.08.495349
Autor:
Bruna R. Muys, Roshan L. Shrestha, Dimitrios G. Anastasakis, Lorinc Pongor, Xiao Ling Li, Ioannis Grammatikakis, Ahsan Polash, Curtis Harris, Mirit I. Aledjem, Munira A. Basrai, Markus Hafner, Ashish Lal
Publikováno v:
SSRN Electronic Journal.
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Defects in chromosome-microtubule attachment can cause chromosomal instability (CIN), frequently associated with infertility and aggressive cancers. Chromosome-microtubule attachment is mediated by a large macromolecular structure, the kinetochore. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbbd287c4dc7bebf9e03789798ad417
https://www.repository.cam.ac.uk/handle/1810/333073
https://www.repository.cam.ac.uk/handle/1810/333073
Defects in chromosome-microtubule attachment can cause chromosomal instability, associated with infertility and aggressive cancers. Chromosome-microtubule attachment is mediated by a large macromolecular structure, the kinetochore. Kinetochore pairs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::accb5fc8ebd386e73790cae85802ced2
https://doi.org/10.1101/2020.12.24.424312
https://doi.org/10.1101/2020.12.24.424312