Supplementary Figures S1-S9, Supplementary Table S1 from Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Autor: Michael E. Pacold, Lewis C. Cantley, Matthias Mann, Eva Hernando, Matthew G. Vander Heiden, Michael A. Davies, Kayvan R. Keshari, Rakesh K. Jain, Jean J. Zhao, Min Yu, Drew R. Jones, David M. Sabatini, Mark Manfredi, Adam Friedman, Vipin Suri, Nello Mainolfi, John H. Healey, Paolo Cotzia, Matija Snuderl, Samuel F. Bakhoum, Benjamin D. Stein, Roshan K. Sriram, Sarah Bacha, Edward R. Kastenhuber, Vinagolu K. Rajasekhar, Ariana Plasger, Jing Ni, Diane S. Kang, Roozbeh Eskandari, Grant M. Fischer, Gino B. Ferraro, Ahmed Ali, Shawn M. Davidson, Alba Luengo, Roger J. Liang, Sophia Bustraan, Sophia Doll, Victoria Osorio-Vasquez, Eugenie Kim, Bryan Ngo

Supplementary Figures and a Supplementary Table

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda6631052d9083df40c06605fff1966
https://doi.org/10.1158/2159-8290.22536382

Data from Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Autor: Michael E. Pacold, Lewis C. Cantley, Matthias Mann, Eva Hernando, Matthew G. Vander Heiden, Michael A. Davies, Kayvan R. Keshari, Rakesh K. Jain, Jean J. Zhao, Min Yu, Drew R. Jones, David M. Sabatini, Mark Manfredi, Adam Friedman, Vipin Suri, Nello Mainolfi, John H. Healey, Paolo Cotzia, Matija Snuderl, Samuel F. Bakhoum, Benjamin D. Stein, Roshan K. Sriram, Sarah Bacha, Edward R. Kastenhuber, Vinagolu K. Rajasekhar, Ariana Plasger, Jing Ni, Diane S. Kang, Roozbeh Eskandari, Grant M. Fischer, Gino B. Ferraro, Ahmed Ali, Shawn M. Davidson, Alba Luengo, Roger J. Liang, Sophia Bustraan, Sophia Doll, Victoria Osorio-Vasquez, Eugenie Kim, Bryan Ngo

A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic constraints imposed by the serine and glycine–limited brain environment restrict metastatic tumor growth. How brain metastases overcome these growth-prohibitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::582a473e89b095f751a52c1fc41c9747
https://doi.org/10.1158/2159-8290.c.6548131.v1

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Autor: Edward R. Kastenhuber, John H. Healey, Lewis C. Cantley, Michael E. Pacold, Paolo Cotzia, Diane Kang, Min Yu, Mark Manfredi, Gino B. Ferraro, Nello Mainolfi, Benjamin D. Stein, Rakesh K. Jain, Matija Snuderl, Roozbeh Eskandari, Alba Luengo, Sophia Doll, Eugenie Kim, Shawn M. Davidson, Roshan K. Sriram, Kayvan R. Keshari, Vipin Suri, Bryan Ngo, David M. Sabatini, Sarah Bacha, Jing Ni, Michael A. Davies, Samuel F. Bakhoum, Roger Liang, Eva Hernando, Ahmed Ali, Ariana Plasger, Victoria Osorio-Vasquez, Drew R. Jones, Matthias Mann, Jean J. Zhao, Vinagolu K. Rajasekhar, Matthew G. Vander Heiden, Sophia Bustraan, Adam Friedman, Grant M. Fischer

Publikováno v: Cancer Discov
PMC

A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic constraints imposed by the serine and glycine–limited brain environment restrict metastatic tumor growth. How brain metastases overcome these growth-prohibitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b92864144a321a889f7423c4a44cf37
https://doi.org/10.1158/2159-8290.cd-19-1228

Metastasis and immune evasion from extracellular cGAMP hydrolysis

Autor: Mercedes Duran, Princesca Dorsaint, Julie-Ann Cavallo, Shin-San Michael Su, Dhruva Biswas, Taha Merghoub, Maria Laura Martin, Sreeram Vallabhaneni, Simon N. Powell, Manuel Salto-Tellez, Jedd D. Wolchok, Neil Vasan, Anusha Kalbasi, Nadeem Riaz, Hannah Y Wen, Samuel F. Bakhoum, Jun Li, Benjamin J DiPardo, Jacqueline James, Charles Swanton, Lee S. Gottesdiener, Olivier Elemento, John Kwon, Benjamin Izar, Alexander N. Shoushtari, Rohan Bareja, Hao Wei Li, Matthew G. Hanna, Johannes C. Melms, Ieva Usaite, Kevin Litchfield, Ninjit Dhanota, Matthew P. Humphries, Eileen Parkes, Travis J Hollmann, Roshan K. Sriram, Chantal Pauli, Sarah E Bettigole, Jorge S. Reis-Filho, Peng Li, Walid K. Chatila

Publikováno v: Li, J, Duran, M A, Dhanota, N, Chatila, W K, Bettigole, S E, Kwon, J, Sriram, R K, Humphries, M P, Salto-Tellez, M, James, J A, Hanna, M G, Melms, J C, Vallabhaneni, S, Litchfield, K, Usaite, I, Biswas, D, Bareja, R, Li, H W, Martin, M L, Dorsaint, P, Cavallo, J-A, Li, P, Pauli, C, Gottesdiener, L, DiPardo, B J, Hollmann, T J, Merghoub, T, Wen, H Y, Reis-Filho, J S, Riaz, N, Su, S-S M, Kalbasi, A, Vasan, N, Powell, S N, Wolchok, J D, Elemento, O, Swanton, C, Shoushtari, A N, Parkes, E E, Izar, B & Bakhoum, S F 2020, ' Metastasis and immune evasion from extracellular cGAMP hydrolysis ', Cancer discovery, vol. Early Online, pp. xx . https://doi.org/10.1158/2159-8290.CD-20-0387
Cancer Discov

Cytosolic DNA is characteristic of chromosomally unstable metastatic cancer cells, resulting in constitutive activation of the cGAS–STING innate immune pathway. How tumors co-opt inflammatory signaling while evading immune surveillance remains unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3a80cefbaee3bdab1ee35690a87c04
https://pure.qub.ac.uk/en/publications/metastasis-and-immune-evasion-from-extracellular-cgamp-hydrolysis(6d7c17ea-11d5-406d-8d68-1f1010b32751).html

Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition

Autor: Jing Ni, Roozbeh Eskandari, Matija Snuderl, Edward R. Kastenhuber, Sophia Doll, Roshan K. Sriram, Rakesh K. Jain, Jean J. Zhao, Sophia Bustraan, Michael E. Pacold, Ahmed Ali, Eugenie Kim, Samuel F. Bakhoum, Edouard Mullarky, Bryan Ngo, Adam Friedman, Nello Mainolfi, Matthias Mann, Drew R. Jones, David M. Sabatini, Vipin Suri, Ariana Plasger, Roger Liang, Shawn M. Davidson, Lewis C. Cantley, Diane Kang, Min Yu, Alba Luengo, Benjamin D. Stein, Sarah Bacha, Mark Manfredi, Gino D. Ferraro, Matthew G. Vander Heiden

Publikováno v: Cancer Research. 80:5712-5712

The metabolic milieu of the brain is severely deprived of nutrients, including the amino acids serine and its catabolite glycine. The metabolic rewiring required for tumor cells to survive in the nutrient-limited environment of the brain and the meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04d87cb3ec58463388bfa48ef3dc155c
https://doi.org/10.1158/1538-7445.am2020-5712