Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rosh Chandraratna"'
Autor:
Alexander J. Ambinder, Kelly Norsworthy, Daniela Hernandez, Laura Palau, Bogdan Paun, Amy Duffield, Rosh Chandraratna, Martin Sanders, Ravi Varadhan, Richard J. Jones, B. Douglas Smith, Gabriel Ghiaur
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Subsets of non-acute promyelocytic leukemia (APL) acute myelogenous leukemia (AML) exhibit aberrant retinoid signaling and demonstrate sensitivity to retinoids in vitro. We present the results of a phase 1 dose-escalation study that evaluated the saf
Externí odkaz:
https://doaj.org/article/3231cdf791a348b9a078c4d69e0c7121
Autor:
Laura Palau, Rosh Chandraratna, Richard J. Jones, Martin E. Sanders, Ravi Varadhan, Alexander J. Ambinder, Amy S. Duffield, Bogdan C. Paun, Gabriel Ghiaur, B. Douglas Smith, Daniela Hernandez, Kelly Norsworthy
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology
Frontiers in Oncology
Subsets of non-acute promyelocytic leukemia (APL) acute myelogenous leukemia (AML) exhibit aberrant retinoid signaling and demonstrate sensitivity to retinoids in vitro. We present the results of a phase 1 dose-escalation study that evaluated the saf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fb2c1dfc2a66b1ecd939f8a9aa7cf8
https://www.frontiersin.org/articles/10.3389/fonc.2020.587062/full
https://www.frontiersin.org/articles/10.3389/fonc.2020.587062/full
Autor:
B. Douglas Smith, Kelly J. Norsworthy, Salvador Alonso, Meng Su, Richard J. Jones, Rosh Chandraratna, Gabriel Ghiaur, Martin Petkovich, Daniela Hernandez, Michelle A. Rudek, Nicole M. Anders, Laura Palau
Publikováno v:
Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c8e33e67f5aa2da31ff12f1bbdba84
https://europepmc.org/articles/PMC7483812/
https://europepmc.org/articles/PMC7483812/
Autor:
Ethan Dmitrovsky, Masanori Karakami, Konstantin H. Dragnev, Rosh Chandraratna, Xi Liu, Jason Roszik, Martin E. Sanders
Publikováno v:
Journal of Clinical Oncology. 35:e14095-e14095
e14095 Background: IRX4204 is a Retinoid X Receptor (RXR) specific agonist (rexinoid). IRX4204 has high potency as a RXR agonist with low binding affinity to Retinoic Acid Receptors (RARs), PPAR, FXR or LXR. Our prior work with the less specific rexi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d7677ce37247b0ab2dec418664c2604
https://doi.org/10.1200/jco.2017.35.15_suppl.e14095
https://doi.org/10.1200/jco.2017.35.15_suppl.e14095
Autor:
Jia-Hao Xiao, Isabelle Dussault, Kevin Hollister, Rosh Chandraratna, Min Lin, Rick Beard, Barry M. Forman, Jasmine Chen
Publikováno v:
The Journal of biological chemistry. 278(9)
BAR is a nuclear bile acid receptor (BAR) (FXR) receptor that regulates gene networks involved in cholesterol and bile acid homeostasis. We have identified two classes of synthetic compounds that differentially modulate BAR activity. The first class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ac7f4b132b185af1490c6d8d432837
https://pubmed.ncbi.nlm.nih.gov/12496277
https://pubmed.ncbi.nlm.nih.gov/12496277
Autor:
Martin E. Sanders, Nazy Zomorodian, Daniel Reif Greenwald, Sheldon J. Davidson, B DiCarlo, Fairooz F. Kabbinavar, Rosh Chandraratna, Faraz Khan, Matthew Rettig, Lalita Pandit, Ravindranath Patel
Publikováno v:
Journal of Clinical Oncology. 32:169-169
169 Background: IRX4204 is a potent, selective, oral small compound agonist of retinoid X receptor (RXR) nuclear receptor pathways. In preclinical studies IRX4204 synergizes with insulin-like growth factor binding protein-3, to induce apoptosis in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a82ab28edb4dd2f1b4ce8dd4101bb6
https://doi.org/10.1200/jco.2014.32.4_suppl.169
https://doi.org/10.1200/jco.2014.32.4_suppl.169
Publikováno v:
Journal of the American College of Cardiology. (2):83A-84A
Background Serotonin (5HT), released from aggregating platelets at sites of vascular injury following coronary angioplasty, is a known mitogen for vascular smooth muscle cells (SMC). Retinoids have been shown to inhibit cellular proliferation possibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5248384ecca641d4d5b46b449d98a9e