Robust temporal map of human in vitro myelopoiesis using single-cell genomics

Autor: Clara Alsinet, Maria Nascimento Primo, Valentina Lorenzi, Erica Bello, Iva Kelava, Carla P. Jones, Roser Vilarrasa-Blasi, Carmen Sancho-Serra, Andrew J. Knights, Jong-Eun Park, Beata S. Wyspianska, Gosia Trynka, David F. Tough, Andrew Bassett, Daniel J. Gaffney, Damiana Alvarez-Errico, Roser Vento-Tormo

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

The myeloid lineage is central to homeostasis and immunity. The authors provide an atlas of human iPSC-to-myeloid cell differentiation and demonstrate that the in vitro system recapitulates yolk sac differentiation, opening new avenues to human myelo

Externí odkaz: https://doaj.org/article/ff14b8d69b054e38a5e0e2b1247d1b45

Aberrant epigenome in iPSC‐derived dopaminergic neurons from Parkinson's disease patients

Autor: Rubén Fernández‐Santiago, Iria Carballo‐Carbajal, Giancarlo Castellano, Roger Torrent, Yvonne Richaud, Adriana Sánchez‐Danés, Roser Vilarrasa‐Blasi, Alex Sánchez‐Pla, José Luis Mosquera, Jordi Soriano, José López‐Barneo, Josep M Canals, Jordi Alberch, Ángel Raya, Miquel Vila, Antonella Consiglio, José I Martín‐Subero, Mario Ezquerra, Eduardo Tolosa

Publikováno v: EMBO Molecular Medicine, Vol 7, Iss 12, Pp 1529-1546 (2015)

Abstract The epigenomic landscape of Parkinson's disease (PD) remains unknown. We performed a genomewide DNA methylation and a transcriptome studies in induced pluripotent stem cell (iPSC)‐derived dopaminergic neurons (DAn) generated by cell reprog

Externí odkaz: https://doaj.org/article/007509ba6a4d4d19940a0fff72f98b85

Dandelionutilizes single cell adaptive immune receptor repertoire to explore lymphocyte developmental origins

Autor: Chenqu Suo, Krzysztof Polanski, Emma Dann, Rik G.H. Lindeboom, Roser Vilarrasa-Blasi, Roser Vento-Tormo, Muzlifah Haniffa, Kerstin B. Meyer, Lisa M. Dratva, Zewen Kelvin Tuong, Menna R. Clatworthy, Sarah A. Teichmann

Assessment of single-cell gene expression (scRNA-seq) and adaptive immune receptor sequencing (scVDJ-seq) has been invaluable in studying lymphocyte biology. Here, we introduceDandelion, a computational pipeline for scVDJ-seq analysis. It enables the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b95ca1a60749960bbce524f1eb989af1
https://doi.org/10.1101/2022.11.18.517068

Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes

Autor: Xose S. Puente, Ana Muntañola, Ander Diaz-Navarro, José I. Martín-Subero, Blanca Espinet, Roser Vilarrasa-Blasi, Guillem Clot, Cristina López, Marta Kulis, Ferran Nadeu, Rafael Valdés-Mas, Vicente Chapaprieta, Marta Aymerich, Dolors Costa, Elias Campo, David Torrents, Sílvia Beà, Jesús Gutiérrez-Abril, Armando López-Guillermo, David Martín-García, Pedro Jares, Ralf Küppers, Eva Giné, Inmaculada Ribera-Cortada, Montserrat Puiggròs, Giancarlo Castellano, Dolors Colomer, Romina Royo, Martí Duran-Ferrer, Alba Navarro, Reiner Siebert

Publikováno v: Blood. 136:1419-1432

Mantle cell lymphoma (MCL) is a mature B-cell neoplasm initially driven by CCND1 rearrangement with 2 molecular subtypes, conventional MCL (cMCL) and leukemic non-nodal MCL (nnMCL), that differ in their clinicobiological behavior. To identify the gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc500617eb285de60b0c605c689d1b3
https://doi.org/10.1182/blood.2020005289

Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation

Autor: Marc A. Marti-Renom, Sílvia Beà, Renée Beekman, Vicente Chapaprieta, Felipe Prosper, Elias Campo, Irene Farabella, José I. Martín-Subero, Núria Verdaguer-Dot, Xabier Agirre, Pol Cuscó, Nuria Russiñol, Ivo Gut, Paula Soler-Vila, Dolors Colomer, Hendrik G. Stunnenberg, Marta Kulis, Guillem Clot, Roser Vilarrasa-Blasi, Marco Di Stefano

Publikováno v: Nature Communications, 12, 1-18
Nature Communications, 12, 1, pp. 1-18
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

To investigate the three-dimensional (3D) genome architecture across normal B cell differentiation and in neoplastic cells from different subtypes of chronic lymphocytic leukemia and mantle cell lymphoma patients, here we integrate in situ Hi-C and n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656d92276a2a4381951c148fb4b9fbd9
http://hdl.handle.net/2066/231392