The Autophagic Activator GHF-201 Can Alleviate Pathology in a Mouse Model and in Patient Fibroblasts of Type III Glycogenosis.

Autor: Mishra K; Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel., Sweetat S; Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel., Baraghithy S; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel., Sprecher U; The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 6997801, Israel., Marisat M; The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 6997801, Israel., Bastu S; Centre de Reference de Maladies Neuromusculaires, UPEC-Paris Est University, IMRB INSERM U955, Team Biology of the Neuromuscular System, Faculty of Medicine, APHP Hopital Henri Mondor, 1 Rue Gustave Eiffel, 94010 Creteil, France., Glickstein H; Electron Microscopy Unit, The Hebrew University-Hadassah Medical School, Ein Kerem, Jerusalem 9112001, Israel., Tam J; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel., Rosenmann H; Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel., Weil M; The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 6997801, Israel., Malfatti E; Centre de Reference de Maladies Neuromusculaires, UPEC-Paris Est University, IMRB INSERM U955, Team Biology of the Neuromuscular System, Faculty of Medicine, APHP Hopital Henri Mondor, 1 Rue Gustave Eiffel, 94010 Creteil, France., Kakhlon O; Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.

Publikováno v: Biomolecules [Biomolecules] 2024 Jul 24; Vol. 14 (8). Date of Electronic Publication: 2024 Jul 24.

The epidemiological and clinical characteristics of patients with young-onset genetic Creutzfeldt-Jakob disease.

Autor: Safadi D; Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel., Cohen OS; Department of Neurology, Assaf Harofeh Medical Center, Tsrifin, Israel.; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Chapman J; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Department of Neurology, The Sagol Neuroscience Center, and Chaim Sheba Medical Center, Ramat gan., Rosenmann H; Department of Neurology,The Agnes Ginges Center for Human Neurogenetics, Hadassa Hebrew University Medical Center, Jerusalem, Israel., Nitsan Z; Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel.; Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel., Kahan E; Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel.; Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel., Appel S; Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel., Alkrenawi M; Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel.

Publikováno v: Neurological research [Neurol Res] 2023 Sep; Vol. 45 (9), pp. 854-857. Date of Electronic Publication: 2023 May 11.

Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice.

Autor: Farfara D; Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel., Sooliman M; Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel., Avrahami L; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel., Royal TG; Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Amram S; Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Rozenstein-Tsalkovich L; Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel., Trudler D; Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Blanga-Kanfi S; Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel., Eldar-Finkelman H; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel., Pahnke J; Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel. jens.pahnke@gmail.com.; Section of Neuropathology, Translational Neurodegeneration Research and Neuropathology Lab, Department of Pathology, University of Oslo (UiO) and Oslo University Hospital (OUS), Oslo, Norway. jens.pahnke@gmail.com.; Drug Development and Chemical Biology, Lübeck Institute of Dermatology (LIED), University Medical Center Schleswig Holstein (UKSH), LIED, Lübeck, Germany. jens.pahnke@gmail.com.; Department of Pharmacology, Faculty of Medicine, University of Latvia, Riga, Latvia. jens.pahnke@gmail.com., Rosenmann H; Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel. rosenmann@hadassah.org.il., Frenkel D; Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel. dfrenkel@tauex.tau.ac.il.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. dfrenkel@tauex.tau.ac.il.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2023 Jul 26; Vol. 20 (1), pp. 174. Date of Electronic Publication: 2023 Jul 26.

Is There Horizontal Transmission of Creutzfeldt-Jakob Disease?

Autor: Balash Y; Department of Neurology, Kaplan Medical Center, Rehovot, Israel, yacovbalash@gmail.com., Kahana E; Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel., Korczyn AD; Departments of Neurology and Physiology and Pharmacology, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Wolker M; Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel., Nabal H; Division of Epidemiology, Ministry of Health, Jerusalem, Israel., Anis E; Division of Epidemiology, Ministry of Health, Jerusalem, Israel., Rosenmann H; Department of Neurology, the Agnes Ginges Center for Human Neurogenetics, Hadassah, Hebrew University Medical Center, Jerusalem, Israel., Milo R; Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel.

Publikováno v: Neuroepidemiology [Neuroepidemiology] 2023; Vol. 57 (3), pp. 156-161. Date of Electronic Publication: 2023 Apr 28.

Sleeve Gastrectomy Reduces Glycemia but Does Not Affect Cognitive Impairment in Lean 5xFAD Mice.

Autor: Samuel I; Department of Developmental Biology and Cancer Research, The Institute of Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel., Ben-Haroush Schyr R; Department of Developmental Biology and Cancer Research, The Institute of Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel., Arad Y; Department of Developmental Biology and Cancer Research, The Institute of Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel.; Department of Military Medicine and Tzameret, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Attali T; Department of Developmental Biology and Cancer Research, The Institute of Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel., Azulai S; Department of Developmental Biology and Cancer Research, The Institute of Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel., Bergel M; Department of Developmental Biology and Cancer Research, The Institute of Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel., Halfon A; Department of Developmental Biology and Cancer Research, The Institute of Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel.; Department of Military Medicine and Tzameret, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Hefetz L; Department of Developmental Biology and Cancer Research, The Institute of Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel.; Department of Military Medicine and Tzameret, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Hirsch T; The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.; The Paul Feder Laboratory on Alzheimer's Disease Research, Bar-Ilan University, Ramat Gan, Israel.; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel., Israeli H; Department of Developmental Biology and Cancer Research, The Institute of Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel., Lax N; Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel., Nitzan K; Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel., Sender D; Department of Developmental Biology and Cancer Research, The Institute of Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel., Sweetat S; Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel., Okun E; The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.; The Paul Feder Laboratory on Alzheimer's Disease Research, Bar-Ilan University, Ramat Gan, Israel.; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel., Rosenmann H; Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel., Ben-Zvi D; Department of Developmental Biology and Cancer Research, The Institute of Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel.

Publikováno v: Frontiers in neuroscience [Front Neurosci] 2022 Aug 11; Vol. 16, pp. 937663. Date of Electronic Publication: 2022 Aug 11 (Print Publication: 2022).