Výsledky vyhledávání - "Rosenkranz, Roberto"

N,N-6-bis-[2-(3,4-dihydroxybenzyl)pyrrolidinyl]hexane, a potent, selective, orally active dopamine analog with hypotensive and diuretic activity

Autor: Roger L. Whiting, Rosenkranz Roberto P, Joseph M. Muchowski, Joan M. Caroon, Mcclelland Deborah L, Richard M. Eglen, Robin D. Clark, Lawrence E. Fisher, Anton D. Michel, Edvige Galeazzi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2371-2376

The D-1 and D-2 affinities, in vivo femoral and renal vasodilatory effects, oral antihypertensive and diuretic effects and syntheses of selected dopamine congeners are described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a12baf334a3eddba10913c6cf19b15d
https://doi.org/10.1016/0960-894x(95)00413-n

Zobrazit plný text záznamu

Periodical

Synthesis and Pharmacological Evaluation of N,N-di-n-Propyldopamine Congeners Containing Phenolic Bioisosteres

Autor: Clark, Robin D., Caroon, Joan M., Isaac, Nancy E., McClelland, Deborah L., Michel, Anton D., Petty, Toni A., Rosenkranz, Roberto P., Waterbury, L. David

Publikováno v: Journal of Pharmaceutical Sciences; May 1987, Vol. 76 Issue: 5 p411-415, 5p

Zobrazit plný text záznamu

Synthesis and pharmacological evaluation of N,N-di-n-propyldopamine congeners containing phenolic bioisosteres

Autor: Toni A. Petty, Joan M. Caroon, Mcclelland Deborah L, A. D. Michel, Robin D. Clark, Rosenkranz Roberto P, L. David Waterbury, Nancy E. Isaac

Publikováno v: Journal of pharmaceutical sciences. 76(5)

A series of analogues of N,N-di-n-propyldopamine (DPDA) in which the 3-hydroxyl group was replaced by bioisosteric groups was prepared and evaluated for D1- and D2-receptor affinity. The 3-methane-sulfonamide analogue (18) had a higher affinity for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518a5641b0b93ee068754da3f6b46f9a
https://pubmed.ncbi.nlm.nih.gov/2958617

Zobrazit plný text záznamu