Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Rosendo Obach"'
Autor:
Concepción Peraire, Joaquim Ramis, Rosendo Obach, Iñaki F. Trocóniz, Josep-María Cendrós, María J. Garrido
Publikováno v:
The Journal of Clinical Pharmacology. 52:487-498
Acromegaly arises from excessive levels of growth hormone (GH), many of whose effects are mediated by stimulation of secretion of insulin-like growth factor 1 (IGF-1). Synthetic somatostatin analogues inhibit GH secretion. The objective of the study
Autor:
Iñaki F. Trocóniz, Rosendo Obach, Cristina Segura, Concepción Peraire, María J. Garrido, Josep-María Cendrós, Paola Principe
Publikováno v:
Cancer Chemotherapy and Pharmacology. 57:727-735
Purpose: To determine the maximum tolerated dose (MTD) of intravenous (iv) diflomotecan administered once every 3 weeks, and to characterize the relationship between pharmacokinetics and neutropenic effect, using a semi-mechanistic pharmacokinetic/ph
Autor:
Sharon Marsh, Alex Sparreboom, Chris Twelves, Howard L. McLeod, Jaap Verweij, Paola Principe, Hans Gelderblom, Ranjeet Ahluwalia, Rosendo Obach
Publikováno v:
Clinical Pharmacology & Therapeutics. 76:38-44
Objective The adenosine triphosphate–binding cassette transporter ABCG2 (breast cancer resistance protein [BCRP]) functions as an efflux transporter for many drugs, including the topoisomerase I inhibitor diflomotecan, and is expressed at high leve
Autor:
Concepción Peraire, M. Montes, Rosendo Obach, M.J. Barbanoj, R. M. Antonijoan, J. Vallès, J. A. Cordero, F. Bismuth, R. CheZérif‐Cheikh, M.‐L. Torres
Publikováno v:
Journal of Pharmacy and Pharmacology. 56:471-476
The pharmacokinetics/tolerability of lanreotide Autogel have been evaluated. Healthy volunteers (n = 24) first received immediate-release lanreotide as a single subcutaneous (s.c.) injection. After two days, 40 or 60 mg lanreotide Autogel was injecte
Autor:
Eric Chetaille, Concepción Peraire, Iñaki F. Trocóniz, Joan Prunynosa, Josep Carreras, Zinnia P. Parra-Guillen, Rosendo Obach
Publikováno v:
Pharmaceutical research. 32(4)
Irosustat is the 'first-in-class' irreversible potent steroid sulphatase inhibitor with lack of oestrogenic activity. The objective of this work was to develop a population model characterizing simultaneously the pharmacokinetic profiles of irosustat
Publikováno v:
Journal of Chromatography A. 870:13-22
An analytical method for the determination of total N-acetylcysteine in human plasma has been developed, validated and applied to the analysis of samples from a phase I clinical trial. The analytical method consists of plasma digestion with dithiothr
Publikováno v:
Journal of Chromatography A. 870:77-86
An analytical method for the determination of paracetamol and chlorpheniramine in human plasma has been developed, validated and applied to the analysis of samples from a phase I clinical trial. The analytical method consists in the extraction of par
Autor:
Concepción Peraire, Nieves Velez de Mendizabal, Elba Romero, Emma Bascompta, Josep-María Cendrós, Iñaki F. Trocóniz, Rosendo Obach
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 342(3)
The objectives of the current work were to develop a predictive population pharmacokinetic (PK)/pharmacodynamic (PD) model for the testosterone (TST) effects of triptorelin (TRP) administered in sustained-release (SR) formulations to patients with pr
Autor:
Ron J. Keizer, Iñaki F. Trocóniz, Mats O. Karlsson, Elena Soto, Rosendo Obach, Lena E. Friberg, Jan H.M. Schellens, Concepción Peraire, Jos H. Beijnen, Josep María Cendrós, Alwin D. R. Huitema, Jantien Wanders
Publikováno v:
Investigational New Drugs
Summary In cancer chemotherapy neutropenia is a common dose-limiting toxicity. An ability to predict the neutropenic effects of cytotoxic agents based on proposed trial designs and models conditioned on previous studies would be valuable. The aim of
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 574:127-133
A sensitive and selective high-performance capillary electrophoresis procedure was developed for the determination of S(+) and R(−) enantiomers of cicletanine in human plasma. The procedure consisted in extraction of the drug with diethyl ether and