Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rosemery Membreno"'
Autor:
Brian M. Zeglis, Jason S. Lewis, Pat B. Zanzonico, Wolfgang W. Scholz, Sean Carlin, Kristen M. Cunanan, Dalya Abdel-Atti, Rosemery Membreno, Jacob L. Houghton
This document contains all supporting materials and methods as well as supplemental figures and tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b48d12bb04fcc036f3c5083d0127ce7
https://doi.org/10.1158/1535-7163.22508922
https://doi.org/10.1158/1535-7163.22508922
Autor:
Jason S. Lewis, Brian M. Zeglis, Wolfgang W. Scholz, Ashwin Ragupathi, Dalya Abdel-Atti, Rosemery Membreno, Komal Mandleywala, Lukas M. Carter, Sophie Poty
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a676f1ba3bbbe25686757b93be6c072
https://doi.org/10.1158/1078-0432.22474679
https://doi.org/10.1158/1078-0432.22474679
Autor:
Jason S. Lewis, Brian M. Zeglis, Wolfgang W. Scholz, Ashwin Ragupathi, Dalya Abdel-Atti, Rosemery Membreno, Komal Mandleywala, Lukas M. Carter, Sophie Poty
Purpose:Interest in targeted alpha-therapy has surged due to α-particles' high cytotoxicity. However, the widespread clinical use of this approach could be limited by on-/off-target toxicities. Here, we investigated the inverse electron-demand Diels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a72af8d3272807e6a03abfe2e8ead5
https://doi.org/10.1158/1078-0432.c.6528869
https://doi.org/10.1158/1078-0432.c.6528869
Autor:
Kathryn M. Tully, Jason S. Lewis, Kimberly Fung, Outi Keinänen, Rosemery Membreno, Brian M. Zeglis, Brendon E. Cook
Publikováno v:
Molecular Pharmaceutics. 16:2259-2263
Pretargeted radioimmunotherapy (PRIT) based on the inverse electron demand Diels–Alder reaction has shown promise in murine models of disease, yet the radiation dosimetry of this approach must be optimized to make it a viable clinical option. To th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca9727ac0f9b46824ac24940bcf476c
https://doi.org/10.1021/acs.molpharmaceut.9b00062
https://doi.org/10.1021/acs.molpharmaceut.9b00062
Autor:
Sophie Poty, Dalya Abdel-Atti, Wolfgang W. Scholz, Ashwin Ragupathi, Komal Mandleywala, Jason S. Lewis, Brian M. Zeglis, Rosemery Membreno, Lukas M. Carter
Publikováno v:
Clinical Cancer Research. 25:868-880
Purpose: Interest in targeted alpha-therapy has surged due to α-particles' high cytotoxicity. However, the widespread clinical use of this approach could be limited by on-/off-target toxicities. Here, we investigated the inverse electron-demand Diel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::787a53eb72c281b16fd9f7c0e16eade9
https://doi.org/10.1158/1078-0432.ccr-18-1650
https://doi.org/10.1158/1078-0432.ccr-18-1650
Autor:
Rosemery Membreno, Ashwin Ragupathi, Jason S. Lewis, Wolfgang W. Scholz, Brian M. Zeglis, Sophie Poty, J M Glaser
Publikováno v:
Chemical Communications. 54:2599-2602
The inverse electron-demand Diels-Alder reaction between tetrazine (Tz) and trans-cyclooctene (TCO) facilitates the efficient radiosynthesis of 225Ac-labelled radioimmunoconjugates in a two-step method, outperforming conventional approaches based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557c9b9999e424ea240ab989e8776529
https://doi.org/10.1039/c7cc09129j
https://doi.org/10.1039/c7cc09129j
Publikováno v:
Journal of Nuclear Medicine. 58:1553-1559
In vivo pretargeting stands as a promising approach to harnessing the exquisite tumor-targeting properties of antibodies for nuclear imaging and therapy while simultaneously skirting their pharmacokinetic limitations. The core premise of pretargeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bef8329ab8788c7bfd4709448c3e44
https://doi.org/10.2967/jnumed.117.189944
https://doi.org/10.2967/jnumed.117.189944
Autor:
Rosemery Membreno, Jason S. Lewis
Publikováno v:
Mol Imaging Biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d02c3044c73451cf0904e976a8ad9de
https://pubmed.ncbi.nlm.nih.gov/31802360
https://pubmed.ncbi.nlm.nih.gov/31802360
Autor:
Pat Zanzonico, Kristen M. Cunanan, Wolfgang W. Scholz, Sean Carlin, Brian M. Zeglis, Rosemery Membreno, Jacob L. Houghton, Dalya Abdel-Atti, Jason S. Lewis
Publikováno v:
Molecular Cancer Therapeutics. 16:124-133
The pretargeting system based on the inverse electron demand Diels-Alder reaction (IEDDA) between trans-cyclooctene (TCO) and tetrazine (Tz) combines the favorable pharmacokinetic properties of radiolabeled small molecules with the affinity and speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d66436f52eef41cb3eaf312c3aaf0e0
https://doi.org/10.1158/1535-7163.mct-16-0503
https://doi.org/10.1158/1535-7163.mct-16-0503
Publikováno v:
Journal of Visualized Experiments.
While radioimmunotherapy (RIT) is a promising approach for the treatment of cancer, the long pharmacokinetic half-life of radiolabeled antibodies can result in high radiation doses to healthy tissues. Perhaps not surprisingly, several different strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f28aea083f6c40119d956cb786cb8a
https://doi.org/10.3791/59041
https://doi.org/10.3791/59041