Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Rosemary Sisco"'
Autor:
Reshma A. Patel, Hong Dong, Ann E. Weber, Joseph K. Wu, Wallace T. Ashton, George A. Doss, Huaibing He, Nancy A. Thornberry, Barbara Leiting, Kathryn A. Lyons, Frank Marsilio, Rosemary Sisco
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2253-2258
A series of β-aminoacylpiperidines bearing various fused five-membered heterocyclic rings was synthesized as dipeptidyl peptidase IV inhibitors. Potent and relatively selective inhibition could be obtained, depending on choice of heterocycle, regioi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7d65b94ebd817ed11ffdfeaf575af7
https://doi.org/10.1016/j.bmcl.2005.03.012
https://doi.org/10.1016/j.bmcl.2005.03.012
Autor:
Mark T. Goulet, Patrice H. Gibbons, Yi Tien Yang, Wallace T. Ashton, Kang Cheng, George R. Mount, Bridget Butler, Rosemary Sisco, Jane-Ling Lo, Joel B. Yudkovitz, Rena Ning Ren
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1727-1731
A pyridine side-chain terminus has been incorporated into the indole-5-carboxamide and indole-5-acetamide series of GnRH antagonists. Potent activity was observed in binding and functional assays. Certain branched or cyclic tertiary amides were ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd14f4097468ba547271025f73a8dfbd
https://doi.org/10.1016/s0960-894x(01)00275-x
https://doi.org/10.1016/s0960-894x(01)00275-x
Autor:
Rosemary Sisco, Joel B. Yudkovitz, Kang Cheng, Yi Tien Yang, Jane-Ling Lo, Wallace T. Ashton, Mark T. Goulet
Publikováno v:
ChemInform. 32
The 2-aryltryptamine class of GnRH receptor antagonists has been modified to incorporate carboxamide and acetamide substituents at the indole 5-position. With either a phenol or methanesulfonamide terminus on the N-aralkyl side chain, potent binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a87dea8e6ee421be04b5de7ea7ae892
https://doi.org/10.1002/chin.200147098
https://doi.org/10.1002/chin.200147098
Autor:
Wallace T. Ashton, Ann E. Weber, Joseph K. Wu, Hong Dong, Rosemary Sisco, George A. Doss, Nancy A. Thornberry, Reshma A. Patel, Frank Marsilio, Barbara Leiting
Publikováno v:
ChemInform. 35
A diastereoselective synthesis was used to prepare a series of (3-substituted-cyclopentyl and -cyclohexyl)glycine pyrrolidides and thiazolidides. The three chiral centers were generated in an unambiguous, stereochemically defined manner. Inhibitory a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c10d79c9f3c726f053e8bae4755f72
https://doi.org/10.1002/chin.200425243
https://doi.org/10.1002/chin.200425243
Autor:
Mark T. Goulet, Rosemary Sisco, Xiaolan Shen, Jisong Cui, An-Hua Mao, Bindhu V. Karanam, Kang Cheng, Gerard R. Kieczykowski, Tsuei-Ju Wu, Kathryn A. Lyons, Rena Ning Ren, Stella H. Vincent, George R. Mount, Yi Tien Yang, Josephine R. Carlin, Wallace T. Ashton, Joel B. Yudkovitz
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(19)
Stereospecific introduction of a methyl group to the indole-3-side chain enhanced activity in our tryptamine-derived series of GnRH receptor antagonists. Further improvements were achieved by variation of the bicyclic amino moiety of the tertiary ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62aa10fe83ceeb8e6e55192fca6d7d38
https://pubmed.ncbi.nlm.nih.gov/11551758
https://pubmed.ncbi.nlm.nih.gov/11551758
Autor:
Wallace T. Ashton, Rosemary Sisco, Kang Cheng, Mark T. Goulet, Joel B. Yudkovitz, Yi Tien Yang, Jane-Ling Lo
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(13)
The 2-aryltryptamine class of GnRH receptor antagonists has been modified to incorporate carboxamide and acetamide substituents at the indole 5-position. With either a phenol or methanesulfonamide terminus on the N-aralkyl side chain, potent binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acfff6411c5e5b7dba77642d97461c0
https://pubmed.ncbi.nlm.nih.gov/11425546
https://pubmed.ncbi.nlm.nih.gov/11425546