Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Rosemary Mayer-Ezel"'
Autor:
Jay S. Fine, James Fossetta, Minglang Wu, Waldemar Gonsiorek, Carol Terminelli, Richard W. Bond, Daniel Lundell, J. Robert Merritt, Aki Cynthia J, Jianhua Chao, Zhenmin He, R. William Hipkin, James Jakway, Younong Yu, Taveras Arthur G, Diane Rindgen, Gaifa Lai, Rosemary Mayer-Ezel, Xuedong Fan, Michael P. Dwyer, Chao Jianping, Hongchen Qiu, Biju J. Purakkattle, Hong Bian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1318-1322
Comprehensive SAR studies were undertaken in the 3,4-diaminocyclobut-3-ene-1,2-dione class of CXCR2/CXCR1 receptor antagonists to explore the role of the heterocycle on chemokine receptor binding affinities, functional activity, as well as oral expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b68dac44b7899c04fed455963d2ae1a
https://doi.org/10.1016/j.bmcl.2008.01.024
https://doi.org/10.1016/j.bmcl.2008.01.024
Autor:
Kaiser Bernd, Aki Cynthia J, Rosemary Mayer-Ezel, Chao Jianping, R. William Hipkin, Richard W. Bond, Taveras Arthur G, Daniel Lundell, Jianhua Chao, Laura L. Rokosz, Purakkattle J. Biju, James Jakway, Viyyoor M. Girijavallabhan, Jay S. Fine, Tara M. Stauffer, James Fossetta, Wei Wang, Ge Li, Hong Bian, J. Robert Merritt, Waldemar Gonsiorek, Xuedong Fan, Baldwin John J, Michael P. Dwyer, Carol Terminelli, Younong Yu, Diane Rindgen, Lynne E. Ozgur
Publikováno v:
Journal of Medicinal Chemistry. 49:7603-7606
Structure-activity studies on lead cyclobutenedione 3 led to the discovery of 4 (SCH 527123), a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist with excellent cell-based activity. Compound 4 displayed good oral bioavailability in rat and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227efbb06ddac971383b73c48f410aca
https://doi.org/10.1021/jm0609622
https://doi.org/10.1021/jm0609622