Výsledky vyhledávání - "Rosemary J Tierney"

Akademický článek

Cooperation between Epstein-Barr virus immune evasion proteins spreads protection from CD8+ T cell recognition across all three phases of the lytic cycle.

Autor: Laura L Quinn, Jianmin Zuo, Rachel J M Abbott, Claire Shannon-Lowe, Rosemary J Tierney, Andrew D Hislop, Martin Rowe

Publikováno v: PLoS Pathogens, Vol 10, Iss 8, p e1004322 (2014)

CD8+ T cell responses to Epstein-Barr virus (EBV) lytic cycle expressed antigens display a hierarchy of immunodominance, in which responses to epitopes of immediate-early (IE) and some early (E) antigens are more frequently observed than responses to

Externí odkaz: https://doaj.org/article/a908d79582d6406eb7c058c1e9359643

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BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus-associated T/NK-cell lymphoma

Autor: Nenad, Sejic, Lindsay C, George, Rosemary J, Tierney, Catherine, Chang, Olga, Kondrashova, Ruth N, MacKinnon, Ping, Lan, Andrew I, Bell, Guillaume, Lessene, Heather M, Long, Andreas, Strasser, Claire, Shannon-Lowe, Gemma L, Kelly

Publikováno v: Blood Adv

Epstein-Barr virus (EBV)–associated T- and natural killer (NK)–cell malignancies, such as extranodal NK-/T-cell lymphoma (ENKTL), exhibit high chemoresistance and, accordingly, such patients have a poor prognosis. The rare nature of such cancers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e03ef6179ab8c4f0de21228eb41b940f
https://pubmed.ncbi.nlm.nih.gov/33017468

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The Epstein-Barr Virus BamHI C Promoter Is Not Essential for B Cell Immortalization In Vitro , but It Greatly Enhances B Cell Growth Transformation

Autor: Rosemary J. Tierney, Jasdeep Nagra, Andrew I. Bell, Alan B. Rickinson, Martin Rowe

Publikováno v: Journal of Virology. 89:2483-2493

Epstein-Barr virus (EBV) infection of B cells leads to the sequential activation of two viral promoters, Wp and Cp, resulting in the expression of six EBV nuclear antigens (EBNAs) and the viral Bcl2 homologue BHRF1. The viral transactivator EBNA2 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2081a7e48b7c66a33da216924091e872
https://doi.org/10.1128/jvi.03300-14

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Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

Autor: Leah, Fitzsimmons, Andrew J, Boyce, Wenbin, Wei, Catherine, Chang, Deborah, Croom-Carter, Rosemary J, Tierney, Marco J, Herold, Andrew I, Bell, Andreas, Strasser, Gemma L, Kelly, Martin, Rowe

Publikováno v: Cell Death and Differentiation

While the association of Epstein–Barr virus (EBV) with Burkitt lymphoma (BL) has long been recognised, the precise role of the virus in BL pathogenesis is not fully resolved. EBV can be lost spontaneously from some BL cell lines, and these EBV-loss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a80451670f6afea75e0bed658ea69eaa
https://pubmed.ncbi.nlm.nih.gov/28960205

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Repression of the Proapoptotic Cellular BIK/NBK Gene by Epstein-Barr Virus Antagonizes Transforming Growth Factor β1-Induced B-Cell Apoptosis

Autor: Andrew I. Bell, Susan Phelan, Rosemary J. Tierney, Roya Hakimjavadi, Dermot Walls, Sinead M. Smith, Paul A. Cahill, Brendan N. D'Souza, Eva M. Campion, Sinéad T. Loughran

Publikováno v: Journal of Virology. 88:5001-5013

The Epstein-Barr virus (EBV) establishes a lifelong latent infection in humans. EBV infection of primary B cells causes cell activation and proliferation, a process driven by the viral latency III gene expression program, which includes EBV nuclear p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f84dc6f84de6eec4607178865b581d
https://doi.org/10.1128/jvi.03642-13

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Epstein-Barr Virus BamHI W Repeat Number Limits EBNA2/EBNA-LP Coexpression in Newly Infected B Cells and the Efficiency of B-Cell Transformation: a Rationale for the Multiple W Repeats in Wild-Type Virus Strains

Autor: Kuan-Yu Kao, Rosemary J. Tierney, Jasdeep Nagra, Alan B. Rickinson

Publikováno v: Journal of Virology. 85:12362-12375

The genome of Epstein-Barr virus (EBV), a gammaherpesvirus with potent B-cell growth-transforming ability, contains multiple copies of a 3-kb BamHI W repeat sequence; each repeat carries (i) a promoter (Wp) that initiates transformation by driving EB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe36769279e04e8233418d26f23f56d
https://doi.org/10.1128/jvi.06059-11

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Epstein–Barr virus latent gene sequences as geographical markers of viral origin: unique EBNA3 gene signatures identify Japanese viruses as distinct members of the Asian virus family

Autor: Maho Koyama-Sato, Masahiro Yasui, Alan B. Rickinson, D. Croom-Carter, Keisei Kawa, Akihisa Sawada, Rosemary J. Tierney, Osamu Kondo, Masami Inoue

Publikováno v: Journal of General Virology. 92:1032-1043

Polymorphisms in Epstein–Barr virus (EBV) latent genes can identify virus strains from different human populations and individual strains within a population. An Asian EBV signature has been defined almost exclusively from Chinese viruses, with lit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe6fde15be71934686722776a3ca913
https://doi.org/10.1099/vir.0.030023-0

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Epstein-Barr Virus Exploits BSAP/Pax5 To Achieve the B-Cell Specificity of Its Growth-Transforming Program

Autor: Alan B. Rickinson, Wolfgang Hammerschmidt, Rosemary J. Tierney, Isabel A. Hutchings, Andrew I. Bell, Claire Shannon-Lowe, Markus Altmann, Jasdeep Nagra

Publikováno v: J. Virol. 81, 10092-10100 (2007)

Epstein-Barr virus (EBV) can infect various cell types but limits its classical growth-transforming function to B lymphocytes, the cells in which it persists in vivo. Transformation initiates with the activation of Wp, a promoter present as tandemly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c360a9300a277c7fc10b17f599845745
https://doi.org/10.1128/jvi.00358-07

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Methylation Status of theEpstein-Barr Virus (EBV) BamHI W Latent Cycle Promoter and Promoter Activity: Analysis with Novel EBV-Positive Burkitt and LymphoblastoidCell Lines

Autor: Alan B. Rickinson, Julianna Stylianou, Gemma L. Kelly, Rosemary J. Tierney, Isabel A. Hutchings, Andrew I. Bell

Publikováno v: Journal of Virology. 80:10700-10711

The Epstein-Barr virus (EBV) latent cycle promoter Wp, present in each tandemly arrayed copy of the BamHI W region in the EBV genome, drives expression of the EB viral nuclear antigens (EBNAs) at the initiation of virus-induced B-cell transformation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c779830013c9031e9f0f39851de5e0b
https://doi.org/10.1128/jvi.01204-06

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