Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Rosemary G. Clarke"'
Autor:
Abigail Brewer, Gajanan Sathe, Billie E. Pflug, Rosemary G. Clarke, Thomas J. Macartney, Gopal P. Sapkota
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109302- (2024)
Summary: Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase. The PP2A holoenzyme complex comprises a scaffolding (A), regulatory (B), and catalytic (C) subunit, with PPP2CA being the principal catalytic subunit. The full scope of PP2A
Externí odkaz:
https://doaj.org/article/f25d696fa64648859afd184fd61b5cbd
Autor:
Hugh A. Nicholson, Lynne Sawers, Rosemary G. Clarke, Kevin J. Hiom, Michelle J. Ferguson, Gillian Smith
Publikováno v:
British Journal of Cancer. 127:1340-1351
Background Ovarian cancer patients frequently develop chemotherapy resistance, limiting treatment options. We have previously shown that individuality in fibroblast growth factor 1 (FGF1) expression influences survival and chemotherapy response. Meth
Autor:
Hugh A, Nicholson, Lynne, Sawers, Rosemary G, Clarke, Kevin J, Hiom, Michelle J, Ferguson, Gillian, Smith
Publikováno v:
British journal of cancer. 127(7)
Ovarian cancer patients frequently develop chemotherapy resistance, limiting treatment options. We have previously shown that individuality in fibroblast growth factor 1 (FGF1) expression influences survival and chemotherapy response.We used MTT assa
Autor:
Rosemary G. Clarke, Christopher A. Maxwell, Graeme Ball, Arlene Whigham, Robert Gourlay, Alan R. Prescott, David G. Campbell, Lin Mei, Zhengcheng He, Joby Varghese, Thomas Macartney, Luke J. Fulcher, Gopal P. Sapkota, Nicola T. Wood
Publikováno v:
EMBO Reports
SummaryThe concerted action of many protein kinases helps orchestrate the error-free progression through mitosis of mammalian cells. The roles and regulation of some prominent mitotic kinases, such as cyclin-dependent kinases, are well-established. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ba05dadf7b6b68bc796a00cd520dbd
Autor:
James Ferguson, Paul Talalay, Ying Zhang, Jed W. Fahey, Albena T. Dinkova-Kostova, Sukirti Kalra, Akira Saito, Suqing Zheng, Maureen Higgins, Elena V. Knatko, Charlotte M. Proby, Robert S. Dawe, Sally H. Ibbotson, Jeffrey T.-J. Huang, Rosemary G. Clarke, Andrea L. Benedict, Tadashi Honda
Publikováno v:
Cancer Prevention Research. 8:475-486
The transcription factor Nrf2 determines the ability to adapt and survive under conditions of electrophilic, oxidative, and inflammatory stress by regulating the expression of elaborate networks comprising nearly 500 genes encoding proteins with vers
Autor:
Arlene Whigham, Diana Madhessian, Tony Ly, Patricia Wadsworth, Emma Lundberg, Alejandro J Brenes-Murillo, Brett Estes, Rosemary G. Clarke, Angus I. Lamond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c124c83b82d17813a1d00e6d71b9d97
https://doi.org/10.7554/elife.27574.030
https://doi.org/10.7554/elife.27574.030
Autor:
Alejandro J Brenes-Murillo, Brett Estes, Patricia Wadsworth, Arlene Whigham, Tony Ly, Angus I. Lamond, Rosemary G. Clarke
The temporal regulation of protein abundance and post-translational modifications is a key feature of cell division. Recently, we analysed gene expression and protein abundance changes during interphase under minimally perturbed conditions (Ly et al.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20c5276333f6ecc8a1b2226e6987849
https://doi.org/10.1101/125831
https://doi.org/10.1101/125831
Autor:
Ram K C Venigalla, Victoria A. McGuire, Laste Stojanovski, Rosemary G. Clarke, Rachel Toth, Janet C. Patterson-Kane, J. Simon C. Arthur, Ayaz Najafov, Frederick R. C. Simeons, Pierre C McCarthy
Publikováno v:
The EMBO Journal
Phosphoinositide-dependent kinase-1 (PDK1) controls the activation of a subset of AGC kinases. Using a conditional knockout of PDK1 in haematopoietic cells, we demonstrate that PDK1 is essential for B cell development. B-cell progenitors lacking PDK1
Autor:
María N. Navarro, Linda V. Sinclair, Rosemary G. Clarke, Doreen A. Cantrell, Carmen Feijoo-Carnero, Sharon A. Matthews
Publikováno v:
Biochemical Journal
PKD (protein kinase D) 2 is a serine/threonine kinase activated by diacylglycerol in response to engagement of antigen receptors in lymphocytes. To explore PKD2 regulation and function in TCR (T-cell antigen receptor) signal transduction we expressed
Autor:
Rosemary G. Clarke, Linda V. Sinclair, Maria Deak, April P. Kelly, Dario R. Alessi, David K. Finlay, Doreen A. Cantrell
Publikováno v:
The Journal of Immunology. 185:5973-5982
This study uses two independent genetic strategies to explore the requirement for phosphoinositide-dependent kinase-1 (PDK1) in the development of mature T cell populations from CD4/CD8 double-positive thymocytes. The data show that CD4/CD8 double-po