Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Rosemary Finnon"'
Autor:
Natalie Brown, Rosemary Finnon, Paul Finnon, Roisin McCarron, Lourdes Cruz-Garcia, Grainne O’Brien, Eleanor Herbert, Cheryl L. Scudamore, Edouard Morel, Christophe Badie
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107530- (2023)
Summary: Ionizing radiation (IR) is a risk factor for acute myeloid leukemia (rAML). Murine rAMLs feature both hemizygous chromosome 2 deletions (Del2) and point mutations (R235) within the hematopoietic regulatory gene Spi1. We generated a heterozyg
Externí odkaz:
https://doaj.org/article/3a11095d3f2342bdb9b60e049777d4d7
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 11 (2021)
Haematopoietic bone marrow cells are amongst the most sensitive to ionizing radiation (IR), initially resulting in cell death or genotoxicity that may later lead to leukaemia development, most frequently Acute Myeloid Leukaemia (AML). The target cell
Externí odkaz:
https://doaj.org/article/abf58c8ed23b4885a46df3ed6bbc927c
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 11, p 1850 (2016)
Scid hematopoietic stem cells (HSCs) have an intrinsic defect in their maintenance within the bone marrow (BM) niche which facilitates HSC transplantation without the absolute requirement of prior conditioning. Nevertheless, NOD scid mice have a sign
Externí odkaz:
https://doaj.org/article/f777aacc02854d39ad0c9b74c3ca41d6
Autor:
Rosemary Finnon, Christophe Badie, Grainne O’Brien, Natalie Brown, Joanna Polanska, Joanna Zyla, Lourdes Cruz-Garcia
Publikováno v:
Carcinogenesis
Therapy-related and more specifically radiotherapy-associated acute myeloid leukaemia (AML) is a well-recognized potential complication of cytotoxic therapy for the treatment of a primary cancer. The CBA mouse model is used to study radiation leukaem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23d0ea0c181be420e1f2c92f26f36a0
https://doi.org/10.1093/carcin/bgz175
https://doi.org/10.1093/carcin/bgz175
Autor:
Tom Verbiest, Paul Finnon, Natalie Brown, Simon Bouffler, Eleanor Ross, Cheryl L. Scudamore, Grainne O’Brien, Christophe Badie, Lourdes Cruz-Garcia, Rosemary Finnon
Publikováno v:
Leukemia
Epidemiological studies have demonstrated an increased leukemia incidence following ionizing radiation exposure, but to date, the target cells and underlying mechanisms of radiation leukemogenesis remain largely unidentified. We engineered a mouse mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4aa4673509af7c60a0c13b7defe194
https://doi.org/10.1038/s41375-018-0085-1
https://doi.org/10.1038/s41375-018-0085-1
Publikováno v:
International journal of radiation biology. 95(4)
The review aims to discuss the prominence of dietary and metabolic regulators in maintaining hematopoietic stem cell (HSC) function, long-term self-renewal, and differentiation.Most adult stem cells are preserved in a quiescent, nonmotile state in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d2e619ad86b5e3e4219ca5f987b062
https://pubmed.ncbi.nlm.nih.gov/29932783
https://pubmed.ncbi.nlm.nih.gov/29932783
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 793:48-54
Leukaemia is the prevailing neoplastic disorder of the hematopoietic system. Epidemiological analyses of the survivors of the Japanese atomic bombings show that exposure to ionising radiation (IR) can cause leukaemia. Although a clear association bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659c434ee5b1eb29ab5bdb6110a15ea9
https://doi.org/10.1016/j.mrgentox.2015.07.012
https://doi.org/10.1016/j.mrgentox.2015.07.012
Autor:
Tom Verbiest, Rosemary Finnon, Christophe Badie, Paul Finnon, Natalie Brown, Justyna Mika, Serge M. Candéias, Joanna Polanska, Simon Bouffler
Publikováno v:
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 2017, 74 (23), pp. 4339-4351 ⟨10.1007/s00018-017-2581-2⟩
Cellular and Molecular Life Sciences, Springer Verlag, 2017, 74 (23), pp. 4339-4351 ⟨10.1007/s00018-017-2581-2⟩
Cellular and Molecular Life Sciences, 2017, 74 (23), pp. 4339-4351 ⟨10.1007/s00018-017-2581-2⟩
Cellular and Molecular Life Sciences, Springer Verlag, 2017, 74 (23), pp. 4339-4351 ⟨10.1007/s00018-017-2581-2⟩
International audience; While the biological effects of high-dose-ionizing radiation on human health are well characterized, the consequences of low-dose radiation exposure remain poorly defined, even though they are of major importance for radiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062665f00e3f082d3f8ba3d789774be3
https://hal.science/hal-01625357
https://hal.science/hal-01625357
Publikováno v:
Mutation Research
Exposure to ionising radiation can lead to an increased risk of cancer, particularly leukaemia. In radiation-induced acute myeloid leukaemia (rAML), a partial hemizygous deletion of mouse chromosome 2 is a common feature in several susceptible strain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ff371543b2f9b58c8abec333735cb1
Publikováno v:
Leukemia Research
The CBA/H mouse model of radiation-induced acute myeloid leukaemia (rAML) has been studied for decades to bring to light the molecular mechanisms associated with multistage carcinogenesis. A specific interstitial deletion of chromosome 2 found in a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1dcfb990628a5f351ed01aeeb203eff
http://europepmc.org/articles/PMC3775122
http://europepmc.org/articles/PMC3775122