Výsledky vyhledávání - "Rosemary E. Morman"

Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T lymphocyte acute lymphoblastic leukemia

Autor: Geoffrey Parriott, Emma Hegermiller, Rosemary E. Morman, Cameron Frank, Caner Saygin, Wendy Stock, Elizabeth T. Bartom, Barbara L. Kee

Publikováno v: bioRxiv

T lymphocyte acute lymphoblastic leukemia (T-ALL) is frequently associated with increased expression of the E protein transcription factor inhibitors TAL1 and LYL1. In mouse models, ectopic expression of Tal1 or Lyl1 in T cell progenitors or inactiva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2a4297883f4a87bd161ba67c086ef8
https://doi.org/10.1101/2023.04.23.537993

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A Mouse Model for the Study of SYK Function through Chemical Genetics Demonstrates SYK-Dependent Signaling through the B Cell Receptor, but Not TLR4

Autor: Robert L. Geahlen, Mariya O. Krisenko, Wen-Horng Wang, Rosemary E. Morman, Reneé Higgins

Publikováno v: ImmunoHorizons. 3:254-261

The SYK protein-tyrosine kinase is a well-known mediator of signals elicited by the clustering of BCR complexes and other receptors that bear components that contain one or more ITAM sequences. Additional roles for the kinase in signaling through oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9555a6b8396a99f1e81368f1d07f00c5
https://doi.org/10.4049/immunohorizons.1800084

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The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude

Autor: Mengxi Sun, Mark Maienschein-Cline, Rosemary E. Morman, Zhong Yin Li, Mikael Sigvardsson, Elizabeth T. Bartom, Emma Hegermiller, Barbara L. Kee

Publikováno v: The Journal of Experimental Medicine

ID2 is an essential transcription factor for natural killer cell development. Through epistasis analysis, Li et al. show that ID2 controls the amplitude of TCF1 and allows for its temporal downregulation, thereby supporting natural killer cell matura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4216725e4f6aec0a780e1da61abebdcf
https://doi.org/10.1084/jem.20202032

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BATF regulates the expression of Nfil3 , Wnt10a and miR155hg for efficient induction of antibody class switch recombination in mice

Autor: Stephen F. Konieczny, Elizabeth J. Taparowsky, Patrick G. Schweickert, Rosemary E. Morman

Publikováno v: European Journal of Immunology. 48:1492-1505

BATF functions in T cells and B cells to control the host response to antigen and promote the production of class switched immunoglobulins. In this study, we demonstrate that BATF expression increases rapidly, and transiently, following B cell stimul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9a563234e7effd134a6ffe63c593c7
https://doi.org/10.1002/eji.201747360

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Identification of BATF target genes critical to its function in immune responses

Autor: Rosemary E Morman, Stacie Poston, Elizabeth J. Taparowsky

Publikováno v: The Journal of Immunology. 196:58.14-58.14

BATF, an immune specific AP-1 transcription factor, functions together with IRF4 and JUNB to regulate genes important for antibody class switch recombination (CSR) in B cells and for the functional differentiation of distinct CD4+ T helper (Th) subse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40f0fdcb3b5af24be9d2c90e1cd91cb2
https://doi.org/10.4049/jimmunol.196.supp.58.14

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