Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Rosemary E. Kelsell"'
Autor:
Andrew D. Randall, Rosemary E. Kelsell, Shaun McNulty, Kerstin Hill, Natalie J. Tigue, Michael Schaefer, Christopher D. Benham
Publikováno v:
Neuropharmacology. 50:89-97
TRPM2, a member of the TRP ion channel family, is expressed both in the brain and immune cells of the monocyte lineage. Functionally, it is unique in its activation by intracellular ADP-ribose and both oxidative and nitrosative stress. To date studie
Autor:
Antonio Riccio, Andrew D. Randall, Andrew D. Medhurst, Menelas N. Pangalos, Rosemary E. Kelsell, Andrew R. Calver, Christopher D. Benham, Cesar Mattei
Publikováno v:
Molecular Brain Research. 109:95-104
The mammalian homologues of the Drosophila transient receptor potential (TRP) channel are plasma membrane proteins involved in the regulation of cellular Ca(2+) influx. These ion channels can be activated subsequent to either depletion of Ca(2+) from
Autor:
Rosemary E. Kelsell, Andrew D. Randall, K. J. Charles, Jeffrey C. Jerman, James Wright, P. Reilly, Darren Smart, Praveen Anand, Julie Egerton, Paul Facer, Lezanne Ooi, Graham D Smith, Philip David Hayes, John B. Davis, Martin J. Gunthorpe, Jean-Philippe Walhin
Publikováno v:
Nature. 418:186-190
Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin. Although VR1
Autor:
Antonio Riccio, Andrew D. Randall, Cesar Mattei, Christopher D. Benham, Rosemary E. Kelsell, Andrew R. Calver, John B. Davis, Andrew D. Medhurst, Menelas N. Pangalos
Publikováno v:
Journal of Biological Chemistry. 277:12302-12309
The regulation and control of plasma membrane Ca(2+) fluxes is critical for the initiation and maintenance of a variety of signal transduction cascades. Recently, the study of transient receptor potential channels (TRPs) has suggested that these prot
Autor:
Andrew D. Randall, David A. Campbell, Malcolm Duckworth, Paul R. Murdock, Helen J. Meadows, Conrad Gerald Chapman, Rosemary E. Kelsell, Gillian I. Rennie, Israel S. Gloger, Rob J. Godden
Publikováno v:
Molecular Brain Research. 82:74-83
We have isolated, by degenerate PCR, a complementary DNA encoding a novel two pore domain potassium channel. This is the 7th functional member of the human tandem pore domain potassium channel family to be reported. It has an open reading frame of 1.
Autor:
Susan M. Downes, Rosemary E. Kelsell, John D. Mollon, Cheryl Y. Gregory-Evans, Rachel M Taylor, Matthew P. Simunovic, Graham E. Holder, Alan C. Bird, David M. Hunt, Kevin Gregory-Evans, Fred W. Fitzke, Anthony T. Moore
Publikováno v:
Ophthalmology. 107:55-61
Objective To describe the clinical features of autosomal dominant cone–rod retinal dystrophy (CRD) in a British family mapping to chromosome 17p12-p13 (CORD6), with a heterozygous mutation (Glu837Asp/Arg838Ser) of GUCY2D . Design A prospective, cli
Autor:
Rosemary E. Kelsell, Sarah C. Woodcock, Visvanathan Ramamurthy, Chandra L. Tucker, David M. Hunt, James B. Hurley
Publikováno v:
Proceedings of the National Academy of Sciences. 96:9039-9044
Mutations in the photoreceptor membrane guanylyl cyclase RetGC-1 have been linked to autosomal dominant cone–rod dystrophy. Three mutations were identified that alter strictly conserved residues within the RetGC-1 dimerization domain, a region pred
Autor:
Cheryl Y. Gregory, Kevin Evans, MB Reichel, David M. Hunt, Fred W. Fitzke, Rosemary E. Kelsell, Joseph Fan, Anthony T. Moore, Alan C. Bird
Publikováno v:
British Journal of Ophthalmology. 82:1162-1168
AIMS—To document the phenotype of an autosomal dominant macular dystrophy diagnosed as having North Carolina macular dystrophy (NCMD) in this British family, and to verify that the disease locus corresponds with that of MCDR1 on chromosome 6q. METH
Autor:
Graham E. Holder, Anthony T. Moore, David M. Hunt, Bernhard H. F. Weber, Alan C. Bird, Rosemary E. Kelsell, Marcelle Jay, Cheryl Y. Gregory-Evans, Kevin Gregory-Evans
Publikováno v:
The American Journal of Human Genetics. 63:274-279
We thank the family members for their cooperation in this study. This work was supported by the Wellcome Trust (grant 041905), the Frost Charitable Trust, and the Foundation Fighting Blindness.
Autor:
Anthony T. Moore, Cheryl Y. Gregory, David M. Hunt, Alan C. Bird, Kevin Evans, Rosemary E. Kelsell
Publikováno v:
Human Molecular Genetics. 6:597-600
We have performed genetic linkage analysis on a four generation British family with cone-rod dystrophy. Significant linkage to the disease gene was obtained with eight marker loci situated on chromosome 17p12-p13. A maximum two-point lod score of 5.9