Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rosemary C. Challis"'
Autor:
Pradeep S. Rajendran, Rosemary C. Challis, Charless C. Fowlkes, Peter Hanna, John D. Tompkins, Maria C. Jordan, Sarah Hiyari, Beth A. Gabris-Weber, Alon Greenbaum, Ken Y. Chan, Benjamin E. Deverman, Heike Münzberg, Jeffrey L. Ardell, Guy Salama, Viviana Gradinaru, Kalyanam Shivkumar
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The wiring of peripheral neural circuits that regulate heart rate is poorly understood. In this study, authors used tissue clearing for high-resolution characterization of nerves in the heart in 3D and transgenic and novel viral vector approaches to
Externí odkaz:
https://doaj.org/article/e62e7c209ae04211ac168bacbbdd12fb
Autor:
Janardhan P. Bhattarai, Xiujuan Zhang, Yiqun Yu, Xuewen Li, Huikai Tian, Shaohua Zhao, Anderson C. Lee, Minghong Ma, Rosemary C. Challis, Hongmeng Yu, Wenwen Ren, Li Wang
Publikováno v:
J Neurosci
The adult olfactory epithelium (OE) regenerates sensory neurons and nonsensory supporting cells from resident stem cells after injury. How supporting cells contribute to OE regeneration remains largely unknown. In this study, we elucidated a novel ro
Autor:
Rosemary C. Challis, Sripriya Ravindra Kumar, Xinhong Chen, David Goertsen, Gerard M. Coughlin, Acacia M. Hori, Miguel R. Chuapoco, Thomas S. Otis, Timothy F. Miles, Viviana Gradinaru
Publikováno v:
Annual review of neuroscience. 45
Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles for neuroscience research. They have two engineerable features: the capsid (outer protein shell) and cargo (encapsulated genome). These features can be modified to e
Autor:
Lian Cui, Jeff Guo, Suna L. Cranfill, Mayank Gautam, Janardhan Bhattarai, William Olson, Katherine Beattie, Rosemary C. Challis, Qinxue Wu, Xue Song, Tobias Raabe, Viviana Gradinaru, Minghong Ma, Qin Liu, Wenqin Luo
Publikováno v:
Neuron
Whether glutamate or itch-selective neurotransmitters are used to confer itch specificity is still under debate. We focused on an itch-selective population of primary afferents expressing MRGPRA3, which highly express Vglut2 and the neuropeptide neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5cdce9d3e4887a15cc8528925646f1
https://europepmc.org/articles/PMC8898340/
https://europepmc.org/articles/PMC8898340/
Autor:
Collin Challis, John D. Tompkins, Hyun Min Kim, Benjamin E. Deverman, Rosemary C. Challis, Ken Y. Chan, Pradeep S. Rajendran, Keith Beadle, Kalyanam Shivkumar, Viviana Gradinaru, Sripriya Ravindra Kumar, Min Jee Jang
Publikováno v:
Nature Protocols. 14:379-414
We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and noninvasive gene transfer to the central and peripheral nervous systems. However, a detailed protocol for generating and systemically delivering novel AAV variants
Autor:
Rosemary C. Challis, Sripriya Ravindra Kumar, Ken Y. Chan, Collin Challis, Keith Beadle, Min J. Jang, Hyun Min Kim, Pradeep S. Rajendran, John D. Tompkins, Kalyanam Shivkumar, Benjamin E. Deverman, Viviana Gradinaru
We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and noninvasive gene transfer to the central and peripheral nervous systems. However, a detailed protocol for generating and systemically delivering novel AAV variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d1c3e014625fd4b030482adcc23de69
https://doi.org/10.17504/protocols.io.bujmnuk6
https://doi.org/10.17504/protocols.io.bujmnuk6
Autor:
Rosemary C. Challis, Sripriya Ravindra Kumar, Ken Y. Chan, Collin Challis, Keith Beadle, Min J. Jang, Hyun Min Kim, Pradeep S. Rajendran, John D. Tompkins, Kalyanam Shivkumar, Benjamin E. Deverman, Viviana Gradinaru
We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and noninvasive gene transfer to the central and peripheral nervous systems. However, a detailed protocol for generating and systemically delivering novel AAV variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d030c5b48050fa0a14d7af5465ff2bc
https://doi.org/10.17504/protocols.io.84ahyse
https://doi.org/10.17504/protocols.io.84ahyse
Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice
Autor:
Collin Challis, Viviana Gradinaru, Laura A. Volpicelli-Daley, Adam M. Hamilton, Rosemary C. Challis, Acacia Hori, Sarkis K. Mazmanian, Timothy R. Sampson, Bryan B. Yoo
Publikováno v:
Nature neuroscience
Parkinson's disease is a synucleinopathy that is characterized by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates. Evidence suggests that α-Syn aggregation can originate in peripheral ti
Autor:
John D. Tompkins, Guy Salama, Sarah Hiyari, Pradeep S. Rajendran, Alon Greenbaum, Peter Hanna, Kalyanam Shivkumar, Beth A. Gabris-Weber, Maria C. Jordan, Viviana Gradinaru, Jeffrey L. Ardell, Ken Y. Chan, Charless C. Fowlkes, Benjamin E. Deverman, Heike Münzberg, Rosemary C. Challis
Publikováno v:
Rajendran, Pradeep S; Challis, Rosemary C; Fowlkes, Charless C; Hanna, Peter; Tompkins, John D; Jordan, Maria C; et al.(2019). Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies.. Nature communications, 10(1), 1944. doi: 10.1038/s41467-019-09770-1. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/505998r7
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Heart rate is under the precise control of the autonomic nervous system. However, the wiring of peripheral neural circuits that regulate heart rate is poorly understood. Here, we develop a clearing-imaging-analysis pipeline to visualize innervation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2998676aec1ab60022a5b87b5fa32e6e
https://doi.org/10.1101/456483
https://doi.org/10.1101/456483
Autor:
Benjamin E. Deverman, Pradeep S. Rajendran, Rosemary C. Challis, Kalyanam Shivkumar, Ken Y. Chan, Sripriya Ravindra Kumar, Min Jee Jang, Viviana Gradinaru, John D. Tompkins, Collin Challis
We recently developed novel AAV capsids for efficient and noninvasive gene transfer across the central and peripheral nervous systems. In this protocol, we describe how to produce and systemically administer AAV-PHP viruses to label and/or geneticall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f94077f1393fa339bddd310f6ee264
https://doi.org/10.1101/246405
https://doi.org/10.1101/246405