Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Rosemary A. Croft"'
Autor:
Juan J. Rojas, Rosemary A. Croft, Alistair J. Sterling, Edward L. Briggs, Daniele Antermite, Daniel C. Schmitt, Luka Blagojevic, Peter Haycock, Andrew J. P. White, Fernanda Duarte, Chulho Choi, James J. Mousseau, James A. Bull
Publikováno v:
Nature Chemistry. 14:160-169
Bioisosteres provide valuable design elements for medicinal chemists to adjust the structural and pharmacokinetic characteristics of bioactive compounds towards viable drug candidates. Aryl oxetane amines offer exciting potential as bioisosteres for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb10e763271769c5461744accae7ca1
https://doi.org/10.1038/s41557-021-00856-2
https://doi.org/10.1038/s41557-021-00856-2
Autor:
James J. Mousseau, James A. Bull, Chulho Choi, Rosemary A. Croft, Yujie Ding, Maryne A. J. Dubois, Dafydd R. Owen
Publikováno v:
RSC Medicinal Chemistry
Oxetanes have received increasing interest in medicinal chemistry as attractive polar and low molecular weight motifs. The application of oxetanes as replacements for methylene, methyl, gem-dimethyl and carbonyl groups has been demonstrated to often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4d4255a385d21ce610bdfb46b3f109
http://hdl.handle.net/10044/1/92594
http://hdl.handle.net/10044/1/92594
Autor:
Anna Lazaridou, Maryne A. J. Dubois, James A. Bull, James J. Mousseau, Camille Denis, Chulho Choi, Ronan Bureau, Alexander J. Boddy, Anne Sophie Voisin-Chiret, Rosemary A. Croft
Publikováno v:
European Journal of Organic Chemistry. 2019:5385-5395
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abb798f4e281c5ea094301e1e6ed1394
https://doi.org/10.1002/ejoc.201900498
https://doi.org/10.1002/ejoc.201900498
Oxetanes have received increasing interest in medicinal chemistry as attractive polar and low molecular weight motifs. The application of oxetanes as replacements for methylene, methyl, gem-dimethyl and carbonyl groups has been demonstrated to often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4e737af2a4c329cce32a959fc811e5f
https://doi.org/10.26434/chemrxiv.14453187.v1
https://doi.org/10.26434/chemrxiv.14453187.v1
Autor:
Juan J, Rojas, Rosemary A, Croft, Alistair J, Sterling, Edward L, Briggs, Daniele, Antermite, Daniel C, Schmitt, Luka, Blagojevic, Peter, Haycock, Andrew J P, White, Fernanda, Duarte, Chulho, Choi, James J, Mousseau, James A, Bull
Publikováno v:
Nature chemistry. 14(2)
Bioisosteres provide valuable design elements that medicinal chemists can use to adjust the structural and pharmacokinetic characteristics of bioactive compounds towards viable drug candidates. Aryl oxetane amines offer exciting potential as bioisost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13357918576733615269561f43d59721
https://pubmed.ncbi.nlm.nih.gov/35087219
https://pubmed.ncbi.nlm.nih.gov/35087219
Publikováno v:
Tetrahedron. 74:5427-5435
Studies on the mechanism and intermediate products in the Friedel–Crafts reaction between oxetanols and phenols are presented. The formation of O-alkylated intermediates is identified using 1H NMR spectroscopy, in a reversible formation of the kine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4f1e5e06a87d713ee1f12fdea3c342
https://doi.org/10.1016/j.tet.2018.02.069
https://doi.org/10.1016/j.tet.2018.02.069
Autor:
Laksmaiah Gingipalli, Jane E. Moore, Rosemary A. Croft, Barlaam Bernard Christophe, Janet Hawkins, Hai-Jun Zhang, Tao Wang, Anil Patel, Lynsie Almeida, Xiaolan Zheng, Kurt Gordon Pike, Timothy Pontz, Allan Dishington, Stephanos Ioannidis, Xiaoyun Wu, Jeffrey W. Johannes, Lorraine A. Hassall, Jane L. Holmes, Thomas M. McGuire
Publikováno v:
Synthesis. 48:1226-1234
Examples of hydroxymethylated analogues of heteroaryl cores such as quinazolin-4-ones, isoquinolin-1(2H)-ones, pyrido[3,4-d]pyrimidin-4(3H)-ones, chromen-4-ones and pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones are sparse or non-existent in the scientific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::975ef5316d7535b960e46c119288e9f6
https://doi.org/10.1055/s-0035-1561355
https://doi.org/10.1055/s-0035-1561355
Publikováno v:
ChemInform. 47
The four-membered oxetane ring has been increasingly exploited for its contrasting behaviors: its influence on physicochemical properties as a stable motif in medicinal chemistry and its propensity to undergo ring-opening reactions as a synthetic int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37cd17b2c0919f835ef1d5a740d9fb7e
https://doi.org/10.1002/chin.201650219
https://doi.org/10.1002/chin.201650219
Publikováno v:
The Journal of organic chemistry. 81(22)
1,4-Dioxenes present interesting potential as synthetic intermediates, and as unusual motifs for incorporation into biologically active compounds. Here, an efficient synthesis of functionalized 1,4-dioxenes is achieved in two steps through a rutheniu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdd07976ad96a920f22143c87b95c1d
https://pubmed.ncbi.nlm.nih.gov/27718575
https://pubmed.ncbi.nlm.nih.gov/27718575
Publikováno v:
Chemical reviews. 116(19)
The four-membered oxetane ring has been increasingly exploited for its contrasting behaviors: its influence on physicochemical properties as a stable motif in medicinal chemistry and its propensity to undergo ring-opening reactions as a synthetic int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d92bdb030d6572b8d29f54fc5bccf0e
https://pubmed.ncbi.nlm.nih.gov/27631342
https://pubmed.ncbi.nlm.nih.gov/27631342