Early switch from intravenous to oral antibiotic therapy in patients with cancer who have low-risk neutropenic sepsis (the EASI-SWITCH trial): study protocol for a randomised controlled trial

Autor: Caroline Forde, Ronan McMullan, Mike Clarke, Richard H. Wilson, Ruth Plummer, Margaret Grayson, Cliona McDowell, Ashley Agus, Annmarie Doran, Danny F. McAuley, Anne L. Thomas, Rosemary A. Barnes, Richard Adams, Ian Chau, Vicky Coyle

Publikováno v: Trials, Vol 21, Iss 1, Pp 1-11 (2020)

Abstract Background Neutropenic sepsis remains a common treatment complication for patients receiving systemic anti-cancer treatment. The UK National Institute for Health and Care Excellence have not recommended switching from empirical intravenous a

Externí odkaz: https://doaj.org/article/a96bb893c04744328d95f321316c5292

A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis

Autor: Keith Wilson, Pierre J. Rizkallah, Magdalena A. Czubala, Aiysha Thompson, Rosemary Ann Barnes, Mark Gurney, James S Griffiths, P. Lewis White, Selinda J. Orr, Elena Simonazzi, Frank L. van de Veerdonk, Wendy Ingram, Philip R. Taylor, Mariolina Bruno, Diogo M da Fonseca, Julian R. Naglik

Publikováno v: The Journal of Infectious Diseases
The Journal of Infectious Diseases, 224, 1219-1224
Griffiths, J S, White, P L, Czubala, M A, Simonazzi, E, Bruno, M, Thompson, A, Rizkallah, P J, Gurney, M, da Fonseca, D M, Naglik, J R, Ingram, W, Wilson, K, van de Veerdonk, F L, Barnes, R, Taylor, P R & Orr, S J 2021, ' A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis ', The Journal of Infectious Diseases . https://doi.org/10.1093/infdis/jiab145
The Journal of Infectious Diseases, 224, 7, pp. 1219-1224

Immunocompromised patients are highly susceptible to invasive aspergillosis. Herein, we identified a homozygous deletion mutation (507 del C) resulting in a frameshift (N170I) and early stop codon in the fungal binding Dectin-2 receptor, in an immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4d6476e23d3ab11b4be29a4e080626
https://doi.org/10.1093/infdis/jiab145

Nucleic Acid Tools for Invasive Fungal Disease Diagnosis

Autor: Volker Rickerts, Rosemary Ann Barnes, Juergen Loeffler, Rebecca Gorton, Alexandre Alanio, J. Peter Donnelly, P. Lewis White, Mario Cruciani, Laurence Millon

Publikováno v: Current Fungal Infection Reports. 14:76-88

This review has incorporated the knowledge and experience of the leads of each of the laboratory working parties of the fungal PCR initiative in order to provide up-to-date information on the performance and developments of PCR methods for the detect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aed2e2ec8e4b977e018d4b0f88c010b9
https://doi.org/10.1007/s12281-020-00374-7

Interlaboratory evaluation of Mucorales PCR assays for testing serum specimens: a study by the fungal PCR Initiative and the Modimucor study group

Autor: Rosemary Ann Barnes, J.P. Donnelly, Valérie Letscher-Bru, S Fuchs, Emeline Scherer, Maud Gits-Muselli, Birgit Willinger, Boualem Sendid, Massimo Cogliati, Ferry Hagen, R Hare, Stéphane Bretagne, Carlo Mengoli, Steffi Rocchi, Martina Lengerová, Michaela Lackner, Julie Denis, J. Loeffler, Alexandre Alanio, Wilfried Posch, P. L. White, Jan Springer, Laurence Millon, Françoise Botterel, Frédéric Dalle, Marie-Elisabeth Bougnoux, Xavier Iriart, C Klaassen, Céline Nourrisson, Céline Damiani, Florent Morio, Marjorie Cornu, Catriona Halliday, Mario Cruciani

Publikováno v: Medical Mycology
Medical Mycology, Oxford University Press, 2021, 59 (2), pp.126-138. ⟨10.1093/mmy/myaa036⟩
Medical Mycology, 59(2), 126-138. Oxford University Press
Medical Mycology. Informa Healthcare

Interlaboratory evaluations of Mucorales qPCR assays were developed to assess the reproducibility and performance of methods currently used. The participants comprised 12 laboratories from French university hospitals (nine of them participating in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a06ca21255b146c5969c0c81159c5c1

Infection in cancer and transplantation

Autor: Rosemary Ann Barnes

Publikováno v: Medicine (Abingdon, England : UK Ed.)

The range of opportunist pathogens in cancer and transplant patients continues to increase. New treatment modalities and forms of immunosuppression following transplantation have improved survival from the underlying disease but can lead to prolonged

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9547770a21474fd30bed1f53d866f54e
https://pubmed.ncbi.nlm.nih.gov/32288573