Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Rosemary A Ndolo"'
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49366 (2012)
Drug distribution in cells is a fundamentally important, yet often overlooked, variable in drug efficacy. Many weakly basic anticancer agents accumulate extensively in the acidic lysosomes of normal cells through ion trapping. Lysosomal trapping redu
Externí odkaz:
https://doaj.org/article/ff8f6756132541a2b8c9f313906f7f9c
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 333:120-128
The distribution behavior of a drug within a cell is an important, yet often overlooked, variable in both activity and differential selectivity. In normal cells, drugs with weakly basic properties are known to be extensively compartmentalized in acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61b7274a41211a68a1ca19caf9a9609
https://doi.org/10.1124/jpet.109.160226
https://doi.org/10.1124/jpet.109.160226
Publikováno v:
Molecular and cellular pharmacology. 2(4)
The therapeutic usefulness of anticancer agents relies on their ability to exert maximal toxicity to cancer cells and minimal toxicity to normal cells. The difference between these two parameters defines the therapeutic index of the agent. Towards th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a10bc4e53e33f9299eec8e5fed11fdb0
https://pubmed.ncbi.nlm.nih.gov/21274418
https://pubmed.ncbi.nlm.nih.gov/21274418