Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Rosemary A Bamford"'
Autor:
Szi Kay Leung, Rosemary A. Bamford, Aaron R. Jeffries, Isabel Castanho, Barry Chioza, Christine S. Flaxman, Karen Moore, Emma L. Dempster, Joshua Harvey, Jonathan T. Brown, Zeshan Ahmed, Paul O’Neill, Sarah J. Richardson, Eilis Hannon, Jonathan Mill
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Increasing evidence suggests that alternative splicing plays an important role in Alzheimer’s disease (AD) pathology. We used long-read sequencing in combination with a novel bioinformatics tool (FICLE) to profile transcript diversity in t
Externí odkaz:
https://doaj.org/article/61f3ea0e8bfe4d4fbbcfd3346aaa8d89
Autor:
Rodrigo R. R. Duarte, Oliver Pain, Matthew L. Bendall, Miguel de Mulder Rougvie, Jez L. Marston, Sashika Selvackadunco, Claire Troakes, Szi Kay Leung, Rosemary A. Bamford, Jonathan Mill, Paul F. O’Reilly, Deepak P. Srivastava, Douglas F. Nixon, Timothy R. Powell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Human endogenous retroviruses (HERVs) are repetitive elements previously implicated in major psychiatric conditions, but their role in aetiology remains unclear. Here, we perform specialised transcriptome-wide association studies that consid
Externí odkaz:
https://doaj.org/article/b450345af2824456a3a8a93c234cbf75
Autor:
Rosemary A Bamford, Zheng-yun Zhao, Neil A Hotchin, Iain B Styles, Gerard B Nash, James H R Tucker, Roy Bicknell
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95097 (2014)
Förster resonance energy transfer (FRET) technology relies on the close proximity of two compatible fluorophores for energy transfer. Tagged (Cy3 and Cy5) complementary DNA strands forming a stable duplex and a doubly-tagged single strand were shown
Externí odkaz:
https://doaj.org/article/23aa865591bc45d09f4e17ec94de7e68
Autor:
Eilis Hannon, Emma L. Dempster, Jonathan P. Davies, Barry Chioza, Georgina E. T. Blake, Joe Burrage, Stefania Policicchio, Alice Franklin, Emma M. Walker, Rosemary A. Bamford, Leonard C. Schalkwyk, Jonathan Mill
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Due to interindividual variation in the cellular composition of the human cortex, it is essential that covariates that capture these differences are included in epigenome-wide association studies using bulk tissue. As experimental
Externí odkaz:
https://doaj.org/article/3d312550f3bb4808b28fa6884c2ceea6
Autor:
Rosemary A. Bamford, Amila Zuko, Madeline Eve, Jan J. Sprengers, Harm Post, Renske L. R. E. Taggenbrock, Dominique Fäβler, Annika Mehr, Owen J. R. Jones, Aurimas Kudzinskas, Josan Gandawijaya, Ulrike C. Müller, Martien J. H. Kas, J. Peter H. Burbach, Asami Oguro-Ando
Publikováno v:
Open Biology, Vol 14, Iss 5 (2024)
The neuronal cell adhesion molecule contactin-4 (CNTN4) is genetically associated with autism spectrum disorder (ASD) and other psychiatric disorders. Cntn4-deficient mouse models have previously shown that CNTN4 plays important roles in axon guidanc
Externí odkaz:
https://doaj.org/article/ba72db2116e74e9ea015ee3338ab6914
Autor:
Asami Oguro-Ando, Rosemary A. Bamford, Wiedjai Sital, Jan J. Sprengers, Amila Zuko, Jolien M. Matser, Hugo Oppelaar, Angela Sarabdjitsingh, Marian Joëls, J. Peter. H. Burbach, Martien J. Kas
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neurodevelopmental and neuropsychiatric disorders, such as autism spectrum disorders (ASD), anorexia nervosa (AN), Alzheimer’s disease (AD), and schizophrenia (SZ), are heterogeneous brain disorders with unknown etiology. Genome wide studi
Externí odkaz:
https://doaj.org/article/53f044de4fd74bb99a68f5ff4e2e7313
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2021)
Autism spectrum disorder (ASD) is characterized by impaired social interaction, language delay and repetitive or restrictive behaviors. With increasing prevalence, ASD is currently estimated to affect 0.5–2.0% of the global population. However, its
Externí odkaz:
https://doaj.org/article/2e7b143b18a74772a295f80a9f0011e5
Autor:
Rosemary A. Bamford, Ashley Smith, Jeremy Metz, Georgina Glover, Richard W. Titball, Stefano Pagliara
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-12 (2017)
Abstract Background Clonal microbial populations often harbor rare phenotypic variants that are typically hidden within the majority of the remaining cells, but are crucial for the population’s resilience to external perturbations. Persister and vi
Externí odkaz:
https://doaj.org/article/2283628220054f6e8b6037028c70d1b9
Autor:
Charli E. Harlow, Josan Gandawijaya, Rosemary A. Bamford, Emily-Rose Martin, Andrew R. Wood, Peter J. van der Most, Toshiko Tanaka, Hampton L. Leonard, Amy S. Etheridge, Federico Innocenti, Robin N. Beaumont, Jessica Tyrrell, Mike A. Nalls, Eleanor M. Simonsick, Pranav S. Garimella, Eric J. Shiroma, Niek Verweij, Peter van der Meer, Ron T. Gansevoort, Harold Snieder, Paul J. Gallins, Dereje D. Jima, Fred Wright, Yi-hui Zhou, Luigi Ferrucci, Stefania Bandinelli, Dena G. Hernandez, Pim van der Harst, Vickas V. Patel, Dawn M. Waterworth, Audrey Y. Chu, Asami Oguro-Ando, Timothy M. Frayling
Publikováno v:
American Journal of Human Genetics, 109(9), 1638-1652. CELL PRESS
Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are currently under clinical development for treating anemia in chronic kidney disease (CKD), but it is important to monitor their cardiovascular safety. Genetic variants can be used a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5af52c8198d180333920474519e29d
https://research.rug.nl/en/publications/dbc76815-e070-4ba9-801d-e653aebb2f58
https://research.rug.nl/en/publications/dbc76815-e070-4ba9-801d-e653aebb2f58
Autor:
Jeremy Metz, Olivia Goode, Stefano Pagliara, Zehra Kahveci, Georgina Glover, Rosemary A. Bamford, Alice L. J. Carr, Ashley Smith, Erin Attrill, Urszula Łapińska
Publikováno v:
ACS Infectious Diseases. 7:1848-1858
Environmental and intracellular stresses can perturb protein homeostasis and trigger the formation and accumulation of protein aggregates. It has been recently suggested that the level of protein aggregates accumulated in bacteria correlates with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de93ff6247156ffa151b847cc124cd92
https://doi.org/10.1021/acsinfecdis.1c00154
https://doi.org/10.1021/acsinfecdis.1c00154