Výsledky vyhledávání - "Rosemarie Sellati"

Proviral integration site 2 is required for interleukin-6 expression induced by interleukin-1, tumour necrosis factor-α and lipopolysaccharide

Autor: Rosemarie Sellati, Jianfei Yang, Tin Min Htut, Xiang Li, Adedayo Hanidu, Lian Wang, Huiping Jiang, Jun Li

Publikováno v: Immunology. 131:174-182

PIM (proviral integration site) kinases are a distinct class of serine/threonine-specific kinases consisting of PIM1, PIM2 and PIM3. PIM2 is known to function in apoptosis pathways. Expression of PIM2 is highly induced by pro-inflammatory stimuli but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c9dc85ee1ec3841b59dcdd80ff654c9
https://doi.org/10.1111/j.1365-2567.2010.03286.x

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Discovery of 2-Phenylamino-imidazo[4,5-h]isoquinolin-9-ones: A New Class of Inhibitors of Lck Kinase

Autor: Maret Panzenbeck, Mario G. Cardozo, Robert M. Tolbert, Jeffrey D. Peterson, Susan Lukas, Stephen Jacober, Robert J. Eckner, Gregory W. Peet, Anthony S. Prokopowicz, Carl A. Busacca, Suresh R. Kapadia, Scott Jakes, Tina Morwick, Roger J. Snow, Rosemarie Sellati, Yong Dong, Matt Aaron Tschantz, Neil Moss

Publikováno v: Journal of Medicinal Chemistry. 45:3394-3405

An imidazo[4,5-h]isoquinolin-7,9-dione (1) was identified as an adenosine 5'-triphosphate competitive inhibitor of lck by high throughput screening. Initial structure-activity relationship studies identified the dichlorophenyl ring and the imide NH a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb66ed0ff6ce36eb079aaec851fb78a
https://doi.org/10.1021/jm020113o

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Collagen-induced arthritis is exacerbated in C-reactive protein-deficient mice

Autor: Rosemarie Sellati, Huiping Jiang, Melissa A. Pegues, Mary McFarland, Lynn Pantages, Jeffrey B. Madwed, Rajvee Parikh, Steven Kerr, Jorge Villalona, Alexander J. Szalai, Valentina Berger, Nicholas R. Jones, Mark A. McCrory

Publikováno v: Arthritis and rheumatism. 63(9)

Blood C-reactive protein (CRP) is routinely measured to gauge inflammation. In rheumatoid arthritis (RA), a heightened CRP level is predictive of a poor outcome, while a lowered CRP level is indicative of a positive response to therapy. CRP interacts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9077b956a2789a9cd10054f98a5cd0
https://pubmed.ncbi.nlm.nih.gov/21567377

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Proviral integration site 2 is required for interleukin-6 expression induced by interleukin-1, tumour necrosis factor-α and lipopolysaccharide

Autor: Jianfei, Yang, Xiang, Li, Adedayo, Hanidu, Tin M, Htut, Rosemarie, Sellati, Lian, Wang, Huiping, Jiang, Jun, Li

Publikováno v: Immunology. 131(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1c47ab544609949fc54f41a1093b9b3
https://pubmed.ncbi.nlm.nih.gov/20465571

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5-Aminomethylbenzimidazoles as potent ITK antagonists

Publikováno v: Bioorganicmedicinal chemistry letters. 19(6)

Benzamide 1 demonstrated good potency as a selective ITK inhibitor, however the amide moiety was found to be hydrolytically labile in vivo, resulting in low oral exposure and the generation of mutagenic aromatic amine metabolites. Replacing the benza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1df8326828e0236a2add4a210c4153e
https://pubmed.ncbi.nlm.nih.gov/19246196

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5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)

Autor: Michael P. Winters, Renee L. DesJarlais, Paul Kaplita, Hnin Hnin Khine, Kevin J. Moriarty, Steven S. Pullen, Ernest L. Raymond, Roger J. Snow, Rosemarie Sellati, Gregory P. Roth, Charles L. Cywin, Thomas M. Farrell, Lisa H. Liu, Mohammed A. Kashem, Hidenori Takahashi, Darius Robinson, Joseph R. Woska, Josephine King, John P. Wolak

Publikováno v: Bioorganicmedicinal chemistry letters. 18(20)

A series of novel 5-aminomethyl-1H-benzimidazole based inhibitors of Itk were prepared. Structure–activity relationships, selectivity and cell activity are reported for this series. Compound 2, a potent and selective antagonist of Itk, inhibited an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f86ef5f6bfbacbc788381beadc24eb
https://pubmed.ncbi.nlm.nih.gov/18823779

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Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t

Autor: Jie Zhao, Tin Min Htut, Xinshou Ouyang, Hongxing Li, Adedayo Hanidu, Rosemarie Sellati, Jay C. Unkeless, Jun Li, Shu Zhang, Jianfei Yang, Huabao Xiong, Xiang Li, Adrian T. Ting, Mark E. Labadia, Martin Hodge, Huiping Jiang, Min Yang, Lloyd Mayer

Publikováno v: European journal of immunology. 38(5)

Epstein-Barr virus-induced gene 3 (EBI3) associates with p28 to form IL-27 and with IL-12p35 to form IL-35. IL-27Ralpha(-/-) mice studies indicate that IL-27 negatively regulates Th17 cell differentiation. However, no EBI3, p28 or p35-deficiency stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c0ec73ad848d587d56cc2433ec77f5
https://pubmed.ncbi.nlm.nih.gov/18412165

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Pyrazinoindolone inhibitors of MAPKAP-K2

Publikováno v: Bioorganicmedicinal chemistry letters. 18(3)

Optimization of pyrazinoindolone inhibitors of MAPKAP-K2 (MK2) provides a reasonable balance of cellular potency and physicochemical properties. Mechanistic studies support the inhibition of MK2 which is responsible for the sub-micromolar cellular ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d0a1a4789b18d191694f405191d34b
https://pubmed.ncbi.nlm.nih.gov/18221871

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