Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Roselyn Lipman"'
Publikováno v:
Chemical Research in Toxicology. 11:64-69
To determine the mutagenic and genotoxic properties of the major guanine N2-adduct formed by the antitumor drug mitomycin C, we have synthesized a decanucleotide, d(TTACGMCTATCT), containing the adduct, which was inserted into a gapped bacteriophage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5158596bbfc898fcb40b1813634b74f0
https://doi.org/10.1021/tx970163+
https://doi.org/10.1021/tx970163+
Publikováno v:
Chemical Research in Toxicology. 9:382-389
Mitomycin C (MC) forms interstrand and intrastrand cross-link adducts and monoalkylation products (monoadducts) with DNA. Each of the three types of adducts was incorporated site-specifically into both a 15-mer and a 21-mer oligodeoxyribonucleotide d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2318388ea2c2dee7d113e119d6c2e17
https://doi.org/10.1021/tx950156q
https://doi.org/10.1021/tx950156q
Publikováno v:
The Journal of Organic Chemistry. 56:4826-4829
The reaction of sodium dithionite activated mitomycin C with guanine at non-cross-linkable sequences in oligonucleotides (as well as DNA) yielded a mixed 1''-deoxyguanosine, 10''-sulfonate mitosene derivative, which has implications for published mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a547cae9108421b632710ee258688fc
https://doi.org/10.1021/jo00016a005
https://doi.org/10.1021/jo00016a005
Publikováno v:
Biochemistry. 30:6444-6453
The mitomycins are a group of antitumor antibiotics that covalently bind to DNA upon reductive activation. Mitomycin A (1b; MA) is more toxic than its clinically useful mitomycin C (1a; MC). The greater toxicity of mitomycin A has been previously att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ad0333ec45352da85255cfc0d409e3
https://doi.org/10.1021/bi00240a015
https://doi.org/10.1021/bi00240a015
Autor:
Mallika Sastry, Suse Broyde, David Live, Maria Tomasz, David Norman, Brian E. Hingerty, Dinshaw J. Patel, Roselyn Lipman
Publikováno v:
Biochemistry. 29:2861-2875
Two-dimensional homonuclear and heteronuclear NMR and minimized potential energy calculations have been combined to define the structure of the antitumor agent mitomycin C (MC) cross-linked to deoxyguanosines on adjacent base pairs in the d(T1-A2-C3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cb7a244ee32c3b81b65d4d568e06a1
https://doi.org/10.1021/bi00463a032
https://doi.org/10.1021/bi00463a032
Publikováno v:
Biochemistry. 29:2999-3006
An extensive series of oligodeoxyribonucleotides was reacted with reductively activated mitomycin C (MC), and the resulting cross-linked drug-oligonucleotide complexes were isolated by reverse-phase HPLC and characterized by nucleoside and MC-nucleos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cd5e8e41a4f0d35948580bd1064c6c
https://doi.org/10.1021/bi00464a016
https://doi.org/10.1021/bi00464a016
Publikováno v:
Biochemistry. 29:2992-2999
Oligodeoxyribonucleotides cross-linked by reductively activated mitomycin C (MC) were prepared and purified for the first time. The cross-linked products were structurally characterized by nucleoside and MC-nucleoside adduct analysis. Optimal conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5d135c648a34bf61879d4182ad70f0f
https://doi.org/10.1021/bi00464a015
https://doi.org/10.1021/bi00464a015
Publikováno v:
Biochemistry. 36(46)
Mitomycin C (MC) was reductively activated by DT-diaphorase [DTD; NAD(P)H:quinone oxidoreductase] from rat liver carcinoma cells in the presence of Micrococcus lysodeicticus DNA at pH 5.8 and 7.4. The resulting alkylated MC-DNA complexes were digeste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1e6269552d7e35fb4809561654a7e7
https://pubmed.ncbi.nlm.nih.gov/9369485
https://pubmed.ncbi.nlm.nih.gov/9369485
Publikováno v:
Journal of molecular biology. 247(2)
Mitomycin C (MC) is a potent antitumor antibiotic which alkylates DNA through covalent linkage of its C-1" position with the exocyclic N2 amino group of guanine to yield the [MC]dG adduct at the duplex level. We report on the solution structure of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b679d30e2dbdab4719f838970f7f599
https://pubmed.ncbi.nlm.nih.gov/7707379
https://pubmed.ncbi.nlm.nih.gov/7707379
Publikováno v:
Biochemistry. 31(5)
Synthetic oligodeoxyribonucleotides were reacted with mitomycin C (MC) under conditions which restricted MC to monofunctional alkylating activity. The yields of monofunctional alkylation of oligonucleotides with variable sequence were determined by e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abde1155d6cccaeb19e6b17464f15255
https://pubmed.ncbi.nlm.nih.gov/1736997
https://pubmed.ncbi.nlm.nih.gov/1736997