Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rosebeth Kagwiria"'
Autor:
Oliver Distler, Alexander Kreuter, B. Merlevede, Andreas Ramming, Ruifang Liang, L. Hallenberger, Aline Bozec, Jörg H W Distler, A. Brandt, Tatiana Mallano, Clara Dees, David Abraham, Yun Zhang, Ioanna Pantelaki, Chih-Wei Chen, Thomas Wohlfahrt, Ralf J. Rieker, Rosebeth Kagwiria, Georg Schett, Christina Bergmann, Sebastian Pötter
ObjectivesSystemic sclerosis (SSc) fibroblasts remain activated even in the absence of exogenous stimuli. Epigenetic alterations are thought to play a role for this endogenous activation. Trimethylation of histone H3 on lysine 27 (H3K27me3) is regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e5254c71e54c2aa8535486b50bf04f
https://www.zora.uzh.ch/id/eprint/142205/
https://www.zora.uzh.ch/id/eprint/142205/
SAT0318 Epigenetic regulation of FRA2 by JMJD3 regulates fibroblast activation in systemic sclerosis
Autor:
Georg Schett, A. Brandt, P-S Kam, Oliver Distler, Clara Dees, David Abraham, Ruifang Liang, C-W Chen, Thomas Wohlfahrt, Yun Zhang, Aline Bozec, Tatjana Mallano, Ralf J. Rieker, Rosebeth Kagwiria, Christina Bergmann, J. H. W. Distler, Andreas Ramming
Publikováno v:
Poster Presentations.
Background Chronic and exaggerated fibroblast activation is a central hallmark of Systemic Sclerosis (SSc) fibrotic disease and results in a high morbidity and mortality. Epigenetic changes might play important roles in mediating chronic fibroblast a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88f0d3d60ed992b14428dccc21f5f10d
https://doi.org/10.1136/annrheumdis-2017-eular.3792
https://doi.org/10.1136/annrheumdis-2017-eular.3792
Autor:
Rosebeth Kagwiria, Christian Beyer, Chih-Wei Chen, Klaus Engelke, Georg Schett, Julia Luther, Jörg H W Distler, Alfiya Distler, Ruifang Liang, Neng-Yu Lin
ObjectivesAutophagy has recently been shown to regulate osteoclast activity and osteoclast differentiation. Here, we aim to investigate the impact of autophagy inhibition as a potential therapeutic approach for the treatment of osteoporosis in precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226baf0b15b61350721ec72a4bd0a149
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/9262
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/9262
Autor:
Aline Bozec, Lucie Heinzerling, Reinhard E. Voll, Manfred Rauh, Zhu Chen, Sandra Mueller-Schmucker, Georg Schett, Rosebeth Kagwiria, Muriel Moser, Richard A. Kroczek, Jean-Pierre David, Andrew L. Mellor, Mario M. Zaiss
Publikováno v:
Science translational medicine. 6(235)
Bone resorption is seminal for the physiological remodeling of bone during life. However, this process needs to be strictly controlled; excessive bone resorption results in pathologic bone loss, osteoporosis, and fracture. We describe a control mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8350152f15ba06c04084b34fff8f92d9
https://pubmed.ncbi.nlm.nih.gov/24861187
https://pubmed.ncbi.nlm.nih.gov/24861187
Autor:
Adrian Stefanica, Julia Luther, Rosebeth Kagwiria, J. H. W. Distler, Alfiya Distler, Oliver Distler, Georg Schett, Christian Beyer, Neng-Yu Lin
Publikováno v:
Annals of the Rheumatic Diseases. 72:A93.2-A93
Background Autophagy is an essential, homeostatic process by which cells digest unnecessary or damaged organelles. Atg7 is essentially required for formation of theautophagosome. The DMARD chloroquine (CQ) has been identified to arrest autophagy func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::369a56cfb8a753dc82b72f7b9bd00ea3
https://doi.org/10.1136/annrheumdis-2013-eular.329
https://doi.org/10.1136/annrheumdis-2013-eular.329