Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Roseanne S Wexler"'
Autor:
Allison M. Martino, James L Ellis, Irina S. Zemtseva, Roseanne S. Wexler, Joseph D. Schroeder, Steward K Richardson, David R. Janero, L. Gordon Letts, Shiow-Jyi Wey, Madhavi G. Murty, Michael E. Augustyniak, William M. Selig, David S. Garvey, A. Mark Trocha, Brian M. Zifcak, Edward Cochran, Terry L. Melim, Delano V. Young, Xinqin Fang
Publikováno v:
Journal of Medicinal Chemistry. 50:6367-6382
Indomethacin, a nonselective cyclooxygenase (COX) inhibitor, was modified in three distinct regions in an attempt both to increase cyclooxygenase-2 (COX-2) selectivity and to enhance drug safety by covalent attachment of an organic nitrate moiety as
Autor:
David R. Janero, Michael C. Warren, Roseanne S. Wexler, Matthew J. Shumway, Vijay Dhawan, Brian M. Zifcak, David J. Schwalb, Irina S. Zemtseva
Publikováno v:
Free Radical Biology and Medicine. 39:1191-1207
Nitric oxide (NO) enhances anti-inflammatory drug action. Through a metabonomics approach termed "NObonomics," the effects of a prototypic NO donor (organic nitrate)-cyclooxygenase-2 inhibitor hybrid (NO-coxib), NMI-1093, on the NO metabolite status
Autor:
Janet S Kerr, Andrea J. Robinson, Candy Robinson, Hui-Yin Li, Roseanne S Wexler, George A. Boswell, Candice M. Krauthauser, Patricia P Harlow
Publikováno v:
Thrombosis Research. 88:127-136
Racemic sodium warfarin, Coumadin,® is widely used in the prevention of thromboembolic disease. The present study was undertaken to characterize three novel classes of warfarin analogs, and to compare them with the warfarin enantiomers. All three cl
Publikováno v:
Current Protocols in Pharmacology
Described in this protocol is a rat preparation that serves as a sensitive, reliable in vivo assay of peripheral vascular resistance. Experiments are conducted on conscious animals 5 days following the surgical implantation of an arterial pressure ca
Autor:
Leslie-Ann M, Hall, Candice M, Krauthauser, Roseanne S, Wexler, Andrew M, Slee, Janet S, Kerr
Publikováno v:
Methods in molecular medicine. 74
Autor:
Patricia P Harlow, Andrea J. Robinson, Janet S Kerr, Roseanne S Wexler, Zhi-Yi Zhang, Laurence S. Kaminsky, Hui-Yin Li
Publikováno v:
Thrombosis research. 88(4)
Human metabolism of the S-warfarin enantiomer is catalyzed primarily by cytochrome P4502C9 (CYP2C9), which, because of the enzyme's broad drug substrate specificity, leads to drug-S-warfarin interactions. Several warfarin analogs have been synthesize
Autor:
Shiow-Jyi Wey, Michael E. Augustyniak, Edward D. Cochran, James L. Ellis, Xinqin Fang, David S. Garvey, David R. Janero, L. Gordon Letts, Allison M. Martino, Terry L. Melim, Madhavi G. Murty, Steward K. Richardson, Joseph D. Schroeder, William M. Selig, A. Mark Trocha, Roseanne S. Wexler, Delano V. Young, Irina S. Zemtseva, Brian M. Zifcak
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 25, p6367-6382, 16p