Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Roseann Petersen"'
Autor:
Charles L. Sawyers, Bangyan L. Stiles, Mehran S. Neshat, Chris Tran, Philip Frost, George Thomas, Ingo K. Mellinghoff, James Joseph Gibbons, Hong Wu, Roseann Petersen
Publikováno v:
Proceedings of the National Academy of Sciences. 98:10314-10319
Recent evidence places the FRAP/mTOR kinase downstream of the phosphatidyl inositol 3-kinase/Akt-signaling pathway, which is up-regulated in multiple cancers because of loss of the PTEN tumor suppressor gene. We performed biological and biochemical s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a53400fd469c9f8518825fa33eb2270e
https://doi.org/10.1073/pnas.171076798
https://doi.org/10.1073/pnas.171076798
Autor:
Vincent Lau, Kim Arndt, Jennifer M. Golas, Diane Tkach, Dave S. Fruhling, Lei Chen, Chaneun Nam, Hao Liu, Roseann Petersen, Qiang Zhao, Frank Boschelli
Publikováno v:
Cell stresschaperones. 15(6)
Cancer cells are exposed to external and internal stresses by virtue of their unrestrained growth, hostile microenvironment, and increased mutation rate. These stresses impose a burden on protein folding and degradation pathways and suggest a route f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29863982904695cb719373e1c2159b30
https://pubmed.ncbi.nlm.nih.gov/20717760
https://pubmed.ncbi.nlm.nih.gov/20717760
Autor:
Frederick Lee, Erik Vogan, Roseann Petersen, Mengxiao Shi, John W. Ellingboe, Jennifer M. Golas, Ariamala Gopalsamy, May S. Tam, Ramaswamy Nilakantan, Kim Arndt, Jaison Jacob, Kristin Svenson, Yingxia Wen, Mark S. Johnson, Rajiv Chopra, Frank Boschelli
Publikováno v:
Journal of medicinal chemistry. 51(3)
Heat shock protein 90 (Hsp90) is a molecular chaperone that is responsible for activating many signaling proteins and is a promising target in tumor biology. We have identified small-molecule benzisoxazole derivatives as Hsp90 inhibitors. Crystallogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711c4b8d4aa444b3259466eaa72ef664
https://pubmed.ncbi.nlm.nih.gov/18197612
https://pubmed.ncbi.nlm.nih.gov/18197612
Autor:
Ariamala Gopalsamy, Mengxiao Shi, Jennifer Golas, Erik Vogan, Jaison Jacob, Mark Johnson, Frederick Lee, Ramaswamy Nilakantan, Roseann Petersen, Kristin Svenson, Rajiv Chopra, May S. Tam, Yingxia Wen, John Ellingboe, Kim Arndt, Frank Boschelli
Publikováno v:
Journal of Medicinal Chemistry; Jan2008, Vol. 51 Issue 3, p373-375, 3p