Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Roseann L. Vorce"'
Autor:
Janee Gelineau-van Waes, Roseann L. Vorce, Eric M. Wauson, Ying Ruan, Richard H. Finnell, Mary H. Peterson
Publikováno v:
Toxicology Letters. 117:129-137
It has been proposed that arsenic exerts its toxic effects, in part, by perturbing cellular methyl metabolism. Based on the hypothesis that folic acid treatment will attenuate the cytotoxic and growth inhibitory effects of arsenic, SWV/Fnn embryo fib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0773988c2b29625fa158db28d648b9
https://doi.org/10.1016/s0378-4274(00)00254-x
https://doi.org/10.1016/s0378-4274(00)00254-x
Publikováno v:
Regulatory Peptides. 87:9-13
Bovine chromaffin cells have been used in a variety of studies designed to reveal different aspects of neuropeptide Y (NPY) action. Pharmacological data have defined five NPY receptor subtypes, only one of which (Y3) has not been cloned. Some studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e268670981abba1ff975f060310f232
https://doi.org/10.1016/s0167-0115(99)00093-2
https://doi.org/10.1016/s0167-0115(99)00093-2
Autor:
Paul M. Stemmer, Stanley A. Swanson, Clare Prince, Keri L. Fakata, William F. Elmquist, Roseann L. Vorce
Publikováno v:
Life Sciences. 62:2441-2448
Cyclosporin A (CsA) is a widely-used immunosuppressant drug whose therapeutic and toxic actions are mediated through inhibition of calcineurin (CN), a calcium- and calmodulin-dependent phosphatase. Inhibition of CN by CsA requires drug binding to its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acc21ae93761f5163845f58379eef1f
https://doi.org/10.1016/s0024-3205(98)00227-6
https://doi.org/10.1016/s0024-3205(98)00227-6
Autor:
Lixin Liao, Roseann L. Vorce
Publikováno v:
Gene. 184:39-43
GAP (GTPase-activating protein), a negative regulator of the receptor tyrosine kinase signal transduction pathway, exists as two isoforms: a ubiquitous, p120 form and a primate placenta-specific p100 form lacking the N-terminal hydrophobic domain. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d591827511c26780f25a4332d5cd848
https://doi.org/10.1016/s0378-1119(96)00571-9
https://doi.org/10.1016/s0378-1119(96)00571-9
Publikováno v:
Cancer Letters. 109:211-215
GAP is a key negative regulator of the receptor tyrosine kinase (RTK) signal transduction pathway. The purpose of this study was to determine if expression or activity of GAP is modulated by hyperstimulation of the RTK pathway. It was found that cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623688ace434a3440adb5e202d8e76be
https://doi.org/10.1016/s0304-3835(96)04456-4
https://doi.org/10.1016/s0304-3835(96)04456-4
Publikováno v:
Biochemical and Biophysical Research Communications. 203:845-851
Alu genes are GC-rich, highly repetitive genetic elements whose functions remain unknown. Members of this family are readily transcribed in vitro by RNA polymerase III, but RNA corresponding to only a small sub-set of Alu elements has been found in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18bd894194782b74083f5d77aef59c7
https://doi.org/10.1006/bbrc.1994.2260
https://doi.org/10.1006/bbrc.1994.2260
Autor:
Lisa Z. Crandall, Roseann L. Vorce
Publikováno v:
Toxicology letters. 136(1)
Exposure to arsenic results in a wide variety of adverse effects. It has been postulated that one mechanism of arsenic toxicity is disruption of cellular methyl biochemistry. Because dietary folate is required to generate the methyl donor S-adenosyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb584caad6a3a8a006e30002038b2588
https://pubmed.ncbi.nlm.nih.gov/12368056
https://pubmed.ncbi.nlm.nih.gov/12368056
Autor:
Tammy Baker, Mary H McMullen, Amy S. Langan, Lisa Z. Crandall, Lixin Liao, Jason G. Glanzer, Roseann L. Vorce
Publikováno v:
Gene. 285(1-2)
ras GTPase activating protein (rasGAP) is highly conserved among mammalian species and is required for normal cardiovascular system development. Expression of this protein exhibits both quantitative and qualitative variability among tissues. Using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52713c78b14e7a248b7410aea8ca3e8
https://pubmed.ncbi.nlm.nih.gov/12039041
https://pubmed.ncbi.nlm.nih.gov/12039041
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 65(2)
Arsenic causes cancer in humans, but its mechanism of action is unique among known carcinogenic agents. As a naturally occurring component of sediments and ground water, human exposure to arsenic is inevitable, necessitating the establishment of expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ad1d0020a74cb85d12ad049d523a7a
https://pubmed.ncbi.nlm.nih.gov/11812918
https://pubmed.ncbi.nlm.nih.gov/11812918
Autor:
Richard H. Finnell, Xiufen Lu, Janee Gelineau-van Waes, Ofer Spiegelstein, Christopher Le, Bogdan J. Wlodarczyk, Roseann L. Vorce
Publikováno v:
Toxicology and applied pharmacology. 177(3)
Arsenic is a well-known carcinogen, which has been suspected of being a human teratogen, although there is currently insufficient and inadequate supportive data to make any definitive judgments. In addition, the significance of individual genetic dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb67fcf1ab880123b3349c1b369e87b
https://pubmed.ncbi.nlm.nih.gov/11749123
https://pubmed.ncbi.nlm.nih.gov/11749123