Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Rose P. Webster"'
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 19, Iss 3 (2023)
ABSTRACTA humanized monoclonal antibody h2E2 designed to bind cocaine with high affinity, specificity, and a long half-life (~7 d in rats) is being developed as a treatment for cocaine use disorder. We report here a pharmacokinetic (PK) study of h2E2
Externí odkaz:
https://doaj.org/article/11df4beb242d4c0db3e7dcfdfd587cab
Publikováno v:
J Immunol Methods
The use of semi-quantitative assays such as the enzyme-linked immunosorbent assay (ELISA) requires stringent quality control of the data. However, such quality control is often lacking in academic settings due to unavailability of software and knowle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf8b3e80b20bf9f8478decb40327af9
https://doi.org/10.1016/j.jim.2017.05.012
https://doi.org/10.1016/j.jim.2017.05.012
Autor:
Moshe Levi, Rashma Faroqui, Dara Burris, Hassane Amlal, Rose P. Webster, John R. Hawse, Sulaiman Sheriff
Publikováno v:
American Journal of Physiology-Renal Physiology. 308:F522-F534
We have previously demonstrated that estrogen (E2) downregulates phosphate transporter NaPi-IIa and causes phosphaturia and hypophosphatemia in ovariectomized rats. In the present study, we examined whether E2directly targets NaPi-IIa in the proximal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19995645a034042b84d5cdbfc3d9d9d0
https://doi.org/10.1152/ajprenal.00386.2014
https://doi.org/10.1152/ajprenal.00386.2014
Autor:
Andrew B. Norman, Fatima O. Saeed, Terence L. Kirley, William J. Ball, Rose P. Webster, Hanna N. Wetzel
We have generated a humanized anti-cocaine monoclonal antibody (mAb), which is at an advanced stage of pre-clinical development. We report here in vitro binding affinity studies, and in vivo pharmacokinetic and efficacy studies of the recombinant mAb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e8112c527ca79521d29423809ca6a0
https://europepmc.org/articles/PMC5560619/
https://europepmc.org/articles/PMC5560619/
Autor:
John R. Hawse, Sulaiman Sheriff, Faraaz Siddiqui, Rashma Faroqui, Hassane Amlal, Rose P. Webster
Estrogen treatment causes renal phosphate (Pi) wasting and hypophosphatemia in rats and humans; however, the signaling mechanisms mediating this effect are still poorly understood. To determine the specific roles of estrogen receptor isoforms (ERα a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931396744ad1723e16fb809ea83da31f
https://europepmc.org/articles/PMC5008677/
https://europepmc.org/articles/PMC5008677/
Autor:
Rose P. Webster, Leslie Myatt
Publikováno v:
Journal of Thrombosis and Haemostasis. 7:375-384
Preeclampsia, a pregnancy-specific syndrome characterized by hypertension, proteinuria and edema, resolves on delivery of the placenta. Normal pregnancy is itself characterized by systemic inflammation, oxidative stress and alterations in levels of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916163a25bb93407a2968190adeff788
https://doi.org/10.1111/j.1538-7836.2008.03259.x
https://doi.org/10.1111/j.1538-7836.2008.03259.x
Publikováno v:
Placenta. 29:985-994
Crucial roles of the placenta are disrupted in early and mid-trimester pregnancy loss, preeclampsia, eclampsia and intrauterine growth restriction. The pathophysiology of these disorders includes a relative hypoxia of the placenta, ischemia/reperfusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc92e0f3674ec14a1f5eee777ac020d
https://doi.org/10.1016/j.placenta.2008.09.003
https://doi.org/10.1016/j.placenta.2008.09.003
Autor:
Rose P. Webster, Leslie Myatt
Publikováno v:
PROTEOMICS – CLINICAL APPLICATIONS. 1:1147-1155
Preeclampsia, a disease of pregnancy, is a multisystem disorder associated with elevated maternal blood pressure, proteinurea, oedema, and fetal abnormalities. It is a major cause of mortality, morbidity, perinatal death, and premature delivery. Desp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da275ff778048f5a6696abd58a13f0ec
https://doi.org/10.1002/prca.200700128
https://doi.org/10.1002/prca.200700128
Autor:
Sulaiman Sheriff, Rashma Faroqui, Hassane Amlal, Rose P. Webster, John R. Hawse, Faraaz Siddiqui
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cab0e23e7d1ee1d2275d84a611742432
https://doi.org/10.1096/fasebj.29.1_supplement.970.2
https://doi.org/10.1096/fasebj.29.1_supplement.970.2
Publikováno v:
MHR: Basic science of reproductive medicine. 12:677-685
Peroxynitrite, a potent pro-oxidant formed from the interaction of superoxide and nitric oxide, has been widely reported to be nitrating tyrosine residues in proteins resulting in the formation of nitrotyrosine. Biological nitration of tyrosine, a fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd89e454ae74a632c7bc5b5c55e030c1
https://doi.org/10.1093/molehr/gal071
https://doi.org/10.1093/molehr/gal071