Age and sex-mediated differences in six-month outcomes after mild traumatic brain injury in young adults: a TRACK-TBI study

Autor: Tene A. Cage, Raquel C. Gardner, Track-Tbi Investigators, Geoffrey T. Manley, Hester F. Lingsma, Sabrina R Taylor, Alex B. Valadka, Esther L. Yuh, Pratik Mukherjee, Mary J. Vassar, Nancy R. Temkin, Catherine G Suen, Ryan R L Phelps, Caitlin K. Robinson, David O. Okonkwo, Molly Rose Morrissey, Hansen Deng, Murray B. Stein, John K. Yue, Harvey S. Levin, Ross C. Puffer, Sourabh Sharma, Sureyya Dikmen, Jason Barber, Ethan A. Winkler, Sarah J Runyon, Jonathan Rick, Maryse C. Cnossen

Publikováno v: Neurol Res
Neurological Research, 41(7), 609-623. Maney Publishing
Neurological research

Introduction: Risk factors for young adults with mTBI are not well understood. Improved understanding of age and sex as risk factors for impaired six-month outcomes in young adults is needed.Methods: Young adult mTBI subjects aged 18-39 years (18-29y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db283c76e2b0dcca4c030bb0fbf0094
https://hdl.handle.net/1765/118822

DNA Polymerase epsilon deficiency causes IMAGe Syndrome with variable immunodeficiency

Autor: Clare V, Logan, Jennie E, Murray, David A, Parry, Andrea, Robertson, Roberto, Bellelli, Žygimantė, Tarnauskaitė, Rachel, Challis, Louise, Cleal, Valerie, Borel, Adeline, Fluteau, Javier, Santoyo-Lopez, Tim, Aitman, Inês, Barroso, Donald, Basel, Louise S, Bicknell, Himanshu, Goel, Hao, Hu, Chad, Huff, Michele, Hutchison, Caroline, Joyce, Rachel, Knox, Amy E, Lacroix, Sylvie, Langlois, Shawn, McCandless, Julie, McCarrier, Kay A, Metcalfe, Rose, Morrissey, Nuala, Murphy, Irène, Netchine, Susan M, O'Connell, Ann Haskins, Olney, Nandina, Paria, Jill A, Rosenfeld, Mark, Sherlock, Erin, Syverson, Perrin C, White, Carol, Wise, Yao, Yu, Margaret, Zacharin, Indraneel, Banerjee, Martin, Reijns, Michael B, Bober, Robert K, Semple, Simon J, Boulton, Jonathan J, Rios, Nicola, Williams

Publikováno v: Logan, C, Murray, J, Parry, D, Robertson, A, Bellelli, R, Tarnauskaite, Z, Challis, R, Cleal, L, Borel, V, Fluteau, A, Santoyo-Lopez, J, SGP Consortium,, Aitman, T, Barroso, I, Basel, D, Bicknell, L, Goel, H, Hu, H, Huff, C, Hutchison, M, Joyce, C, Knox, R, Langlois, S, McCandless, S, McCarrier, J, Morrissey, R, Murphy, N, Netchine, I, O'Connell, S M, Olney, A H, Paria, N, Rosenfeld, J A, Sherlock, M, Syverson, E, White, P, Wise, C, Yu, Y, Zacharin, M, Banerjee, I, Reijns, M, Bober, M B, Semple, R, Boulton, S J, Rios, J J, Jackson, A & Robertson, A 2018, ' DNA Polymerase epsilon deficiency causes IMAGe Syndrome with variable immunodeficiency ', American Journal of Human Genetics, vol. 103, no. 6, pp. 1038-1044 . https://doi.org/10.1016/j.ajhg.2018.10.024
American Journal of Human Genetics

During genome replication, polymerase epsilon (Pol ε) acts as the major leading-strand DNA polymerase. Here we report the identification of biallelic mutations in POLE, encoding the Pol ε catalytic subunit POLE1, in 15 individuals from 12 families.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5251341d775fe05227776575d532ec23
https://hdl.handle.net/20.500.11820/a5b9ba45-d8e4-483e-867c-a0708daa62f5

Geriatric Traumatic Brain Injury: Epidemiology, Outcomes, Knowledge Gaps, and Future Directions

Autor: Molly Rose Morrissey, Raquel C. Gardner, Kristen Dams-O'Connor, Geoffrey T. Manley

Publikováno v: Journal of neurotrauma, vol 35, iss 7

This review of the literature on traumatic brain injury (TBI) in older adults focuses on incident TBI sustained in older adulthood ("geriatric TBI") rather than on the separate, but related, topic of older adults with a history of earlier-life TBI. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2715a369392b4966999315c42cd5674
https://europepmc.org/articles/PMC5865621/

P1-575: PRE-INJURY MILD COGNITIVE IMPAIRMENT IN OLDER ADULTS PRESENTING ACUTELY WITH TRAUMATIC BRAIN INJURY: THE TRANSFORMING RESEARCH AND CLINICAL KNOWLEDGE IN GERIATRIC TBI PILOT STUDY (TRACK-GERI PILOT)

Autor: Chelsea Camara, Molly Rose Morrissey, Michele Diaz, Raquel C. Gardner, Geoffrey T. Manley

Publikováno v: Alzheimer's & Dementia. 15:P496-P496

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d68f9a8dc16ea7f7f0edcc367ba5e1ca
https://doi.org/10.1016/j.jalz.2019.06.1180