Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Rose M. Evans"'
Autor:
Bergstrom James D, Carol Ann Keohane, Suzanne M. Mandala, Stephen A. Parent, Sander G. Mills, Elizabeth J. Quackenbush, L. Alexandra Wickham, Mark Rosenbach, Hugh Rosen, Weirong Chen, Christopher L. Lynch, Rose M. Evans, Hugo M. Vargas, Jeffrey J. Hale, Deborah Card, Gan-Ju Shei, Michael J. Forrest, Gary L. Chrebet, Zhen Li, Richard Hajdu, James A. Milligan
Publikováno v:
Journal of Medicinal Chemistry. 48:6169-6173
A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P1) receptor agonists with minimal affinity for the S1P2 and S1P3 receptor subtypes. Analogue 26 (S1P1 IC50 = 0.6 nM) has an excellen
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:e59