Rabbit models of human diseases for diagnostics and therapeutics development

Autor: Rose G. Mage, Christoph Rader, Pedro J. Esteves

Publikováno v: Developmental & Comparative Immunology. 92:99-104

This review presents some examples of studies using the European rabbit (Oryctolagus cuniculus) that have led to, and continue to, contribute to advancement of understanding of human diseases as well as therapeutics development. In addition, we tabul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d8e99762af400a78ecd4f69e82089d
https://doi.org/10.1016/j.dci.2018.10.003

The wide utility of rabbits as models of human diseases

Autor: Xiang-Peng Kong, Jacques Le Pendu, Selvakumar Subbian, Dennis K. Lanning, Ana M. Lopes, Natalie Ruvoën-Clouet, Katherine L. Knight, Joana Abrantes, Javier González-Gallego, Xuwen Peng, Lbachir BenMohamed, Ana Acacia S. Pinheiro, Michael Vaine, Lorenzo Giacani, Rose G. Mage, Neil D. Christensen, Wessel van der Loo, Shuying Liu, Pedro J. Esteves, María J. Tuñón, Fabiana Neves, Masmudur M. Rahman, Yuxing Chen, Hanna Mari Baldauf, Ana Lemos de Matos, Ruimin Pan, Jia Liu, Laura E. Via, Patrícia de Sousa-Pereira, Jiafen Hu, Shixia Wang, Oliver T. Keppler, Grant McFadden, Shan Lu, Sheila A. Lukehart, Gilla Kaplan, Yukari C. Manabe

Publikováno v: Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 50, Iss 5, Pp 1-10 (2018)
Experimental & Molecular Medicine, Nature Publishing Group, 2018, 50 (5), pp.66. ⟨10.1038/s12276-018-0094-1⟩
Experimental & Molecular Medicine, 2018, 50 (5), pp.66. ⟨10.1038/s12276-018-0094-1⟩

Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification mechanisms and continue to be valuable for the development and testing of therapeutic humanized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c459be79159418ee67bb00756f31e7
https://doi.org/10.1038/s12276-018-0094-1

Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication

Autor: Jeremy A. Johnson, Guillaume Queney, Sarah Young, G. Bolet, Frank W. Albert, Anqi Xiong, Gerli Pielberg, Rose G. Mage, Leif Andersson, Samuel Boucher, Alvaro Martinez Barrio, Shady Younis, Carl-Johan Rubin, Nima Rafati, Kerstin Lindblad-Toh, Magali Ruffier, Eric S. Lander, Sandra Afonso, Bronwen Aken, Shumaila Sayyab, Federica Di Palma, Miguel Carneiro, Claire Rogel-Gaillard, Jessica Alföldi, Karin Forsberg-Nilsson, Jeffrey M. Good, Nuno Ferrand, Steve Searle, Rita Campos, Jean L. Chang, Luca Fontanesi, Daniel Barrell, Rafael Villafuerte, Hernán A. Burbano, Joel M. Alves, Ze Peng, Hervé Garreau, David I. Heiman, Véronique Duranthon, Jason Turner-Maier

Publikováno v: Science
Science, American Association for the Advancement of Science, 2014, 345 (6200), pp.1074-1079. ⟨10.1126/science.1253714⟩
Science, American Association for the Advancement of Science, 2014, 345 (6200), pp.1074-1079. ⟨10.1126/science.1253714 ⟩

Rabbits softly swept to domestication When people domesticate animals, they select for tameness and tolerance of humans. What else do they look for? To identify the selective pressures that led to rabbit domestication, Carneiro et al. sequenced a dom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130ff8192bfb8644ec6c25580834fcda
https://doi.org/10.1126/science.1253714

Accuracy and coverage assessment of Oryctolagus cuniculus (rabbit) genes encoding immunoglobulins in the whole genome sequence assembly (OryCun2.0) and localization of the IGH locus to chromosome 20

Autor: Richa Agarwala, E. Michael Gertz, Amélie Bonnet-Garnier, Hélène Hayes, Rose G. Mage, Alejandro A. Schäffer, Claire Rogel-Gaillard

Publikováno v: Immunogenetics
Immunogenetics, Springer Verlag, 2013, 65 (10), pp.749-762. ⟨10.1007/s00251-013-0722-9⟩

We report on the analyses of genes encoding immunoglobulin heavy and light chains in the rabbit 6.51× whole genome assembly. This OryCun2.0 assembly confirms previous mapping of the duplicated IGK1 and IGK2 loci to chromosome 2 and the IGL lambda li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce500a6ac756eaafdc6bc31f334f5e3
https://doi.org/10.1007/s00251-013-0722-9

Characterization of rabbit CD5 isoforms

Autor: Rose G. Mage, Richard Pospisil, Juraj Kabat

Publikováno v: Molecular Immunology

Previously described polyclonal or monoclonal antibodies (mAb) to rabbit CD5, raised against expressed recombinant protein or peptides, recognize CD5 on most rabbit B cells. The mAb KEN-5 was originally reported to recognize rabbit CD5. However, KEN-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e27cd4070fd11ef96d59aab6dcee7e