Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Rose Flick"'
Autor:
Mali Cosden, Sarah Jinn, Lihang Yao, Cheryl A. Gretzula, Monika Kandebo, Dawn Toolan, Nathan G. Hatcher, Lei Ma, Wei Lemaire, Gregory C. Adam, Christine Burlein, Christina Minnick, Rose Flick, Marla L. Watt, James Mulhearn, Mark Fraley, Robert E. Drolet, Jacob N. Marcus, Sean M. Smith
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105507- (2021)
Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD). GCase metabolizes the glycosphingolipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSp
Externí odkaz:
https://doaj.org/article/5bb119e476704557a1fe920f9ef43979
Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation
Autor:
Denise J. Bickel, Lone Veng, Marlene A. Jacobson, William J. Ray, K. H. Jones, Cyrille Sur, Danette Pascarella, Marion Wittmann, Rose Flick, Michelle Pearson, Constantine Kreatsoulas, Paul J. Shughrue, Scott M. Doran, Craig W. Lindsley, Gene G. Kinney, Matthew A. Seager, Guy R. Seabrook, Alexander McCampbell, Maryann Burno, William D. Shipe, Valerie Kuzmick Graufelds, Andrew Danziger, Lei Ma, Christopher P. Regan, Scott D. Kuduk, Guangping Xu, Susan L. Garson, Renee C. Gaspar
The forebrain cholinergic system promotes higher brain function in part by signaling through the M 1 muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), these cholinergic neurons degenerate, therefore selectively activating M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883d52a829eb7f4a1dfa08990154309a
https://europepmc.org/articles/PMC2732705/
https://europepmc.org/articles/PMC2732705/
