Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rose E. May"'
Autor:
Andrew J. Kueh, Maria I. Bergamasco, Anna Quaglieri, Belinda Phipson, Connie S.N. Li-Wai-Suen, Ingrid M. Lönnstedt, Yifang Hu, Zhi-Ping Feng, Chris Woodruff, Rose E. May, Stephen Wilcox, Alexandra L. Garnham, Michael P. Snyder, Gordon K. Smyth, Terence P. Speed, Tim Thomas, Anne K. Voss
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111980- (2023)
Summary: In the conventional model of transcriptional activation, transcription factors bind to response elements and recruit co-factors, including histone acetyltransferases. Contrary to this model, we show that the histone acetyltransferase KAT7 (H
Externí odkaz:
https://doaj.org/article/4b0b1023c1f947b38cbb26ac1b1ba97c
Autor:
Alex R.D. Delbridge, Andrew J. Kueh, Francine Ke, Natasha M. Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E. May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J. Herold, Ygal Haupt, Gordon K. Smyth, Tim Thomas, Marnie E. Blewitt, Andreas Strasser, Anne K. Voss
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 442-454.e5 (2019)
Summary: Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor suppressor p53 display NTDs with incomplete penetrance. We found that the combined loss of pro-apoptotic BIM and
Externí odkaz:
https://doaj.org/article/09ca82a5c071461f8a7c7c4007a851a9
Autor:
Farrah El-Saafin, Maria I. Bergamasco, Yunshun Chen, Rose E. May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J. Davis, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Anne K. Voss
Publikováno v:
Cell Death Differ
Mutations in genes encoding general transcription factors cause neurological disorders. Despite clinical prominence, the consequences of defects in the basal transcription machinery during brain development are unclear. We found that loss of the TATA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f220a01b3615cf66d97fa58ea30c26c
https://doi.org/10.1038/s41418-022-00982-5
https://doi.org/10.1038/s41418-022-00982-5
Autor:
Marnie E. Blewitt, Tamara Beck, Yifang Hu, Francine Ke, Rose E. May, Farrah El-Saafin, Andreas Strasser, William Chiang, Lin Tai, Tim Thomas, Natasha Jansz, Megan Iminitoff, Andrew J. Kueh, Sue Haupt, Gordon K. Smyth, Marco J Herold, Alex R. D. Delbridge, Lachlan Whitehead, Gao-Yuan Wang, Anne K. Voss, Natasha Zamudio, Ygal Haupt
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 442-454.e5 (2019)
Summary: Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor suppressor p53 display NTDs with incomplete penetrance. We found that the combined loss of pro-apoptotic BIM and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cef3d31dea9f94cb71498f96a52f2a6
http://www.sciencedirect.com/science/article/pii/S221112471930364X
http://www.sciencedirect.com/science/article/pii/S221112471930364X
Autor:
Andrew J. Kueh, Alexandra L. Garnham, Leonie Tang, Samantha Eccles, Rose E. May, Anne K. Voss, Gordon K. Smyth, Marco J Herold, Tim Thomas
Publikováno v:
Mol Cell Biol
HBO1 (MYST2/KAT7) is essential for histone 3 lysine 14 acetylation (H3K14ac) but is dispensable for H4 acetylation and DNA replication in mouse tissues. In contrast, previous studies using small interfering RNA (siRNA) knockdown in human cell lines h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba1245828f5d375d3b2aee3840bdc11
https://europepmc.org/articles/PMC6996278/
https://europepmc.org/articles/PMC6996278/
Autor:
Helen M. McRae, Ian P. Street, John D. Bentley, Edwin D. Hawkins, Brandon J. Aubrey, Karen L. White, Bin Ren, Matthew L. Dennis, Meghan Hattarki, Stephen Mieruszynski, Natasha Zamudio, Gordon K. Smyth, M.C. Chung, Andrew J. Sealey, Maria I. Bergamasco, Guido Pacini, Natalie L. Downer, Jonathan B. Baell, Andreas Strasser, Jai Rautela, Ricky W. Johnstone, Nghi H. Nguyen, Alexandra L. Garnham, Bilal N. Sheikh, Andrea Newbold, Gemma L. Kelly, David J. Leaver, Pat Pilling, Rose E. May, Nicholas D. Huntington, Johannes Wichmann, Yuquing Yang, Tim Thomas, S.J. Hermans, Hannah K. Vanyai, Anne K. Voss, Beinan Wang, H. Rachel Lagiakos, Brendon J. Monahan, Bethany K. Davey, Stephen Wilcox, Melanie de Silva, Olan Dolezal, Michael W. Parker, Susan A. Charman, Margs S. Brennan, Kimberly J. Morgan, Karen Doggett, Joan K. Heath, Thomas S. Peat, Benjamin Cleary, Hendrik Falk
Publikováno v:
Nature. 560:253-257
Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function1. Among the genes coding for the MYST family of KATs (KAT5-KAT8) are the oncogenes KAT6A (also known as MOZ) and KAT6B (also known as MOR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72783118ee7d6182bff8b36cfd55635
https://doi.org/10.1038/s41586-018-0387-5
https://doi.org/10.1038/s41586-018-0387-5
Autor:
Andreas Strasser, William Chiang, Brandon J. Aubrey, Antonia N. Policheni, Mathew P. Dixon, Alexandra L. Garnham, Jozef Gecz, Matthew P. McCormack, Anne K. Voss, Axel Kallies, Kevin Man, Yifang Hu, Andrew J. Kueh, Tim Thomas, Stephen Wilcox, Daniel H.D. Gray, Renee Gloury, Tan A. Nguyen, Gordon K. Smyth, Helen M. McRae, Rose E. May, Edwin D. Hawkins, Ladina Di Rago, Bilal N. Sheikh, Matthew T. Witkowski, Warren S. Alexander, Mark A. Corbett
Somatically acquired mutations in PHF6 (plant homeodomain finger 6) frequently occur in hematopoietic malignancies and often coincide with ectopic expression of TLX3. However, there is no functional evidence to demonstrate whether these mutations con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95df0fc9d04059dd9be253eb79941150
https://europepmc.org/articles/PMC6695515/
https://europepmc.org/articles/PMC6695515/
Autor:
Tim Thomas, Hannah K. Vanyai, Rose E. May, Caitlin Collin, Stephen Wilcox, Helen M. McRae, Anne K. Voss, Alexandra L. Garnham, Gordon K. Smyth
Publikováno v:
Development (Cambridge, England). 146(14)
Oral clefts are common birth defects. Individuals with oral clefts who have identical genetic mutations regularly present with variable penetrance and severity. Epigenetic or chromatin-mediated mechanisms are commonly invoked to explain variable pene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559bc688357910854ef583b4e896e668
https://pubmed.ncbi.nlm.nih.gov/31340933
https://pubmed.ncbi.nlm.nih.gov/31340933
Autor:
Gordon K. Smyth, Belinda Phipson, Anne K. Voss, Farrah El-Saafin, Bilal N. Sheikh, Natalie L. Downer, Rose E. May, Matthew Bird, Andrew J. Kueh, Tim Thomas, Hannah K. Vanyai
Publikováno v:
Oncogene. 34:5807-5820
Cellular senescence is an important mechanism that restricts tumour growth. The Ink4a-Arf locus (also known as Cdkn2a), which encodes p16(INK4A) and p19(ARF), has a central role in inducing and maintaining senescence. Given the importance of cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085651594ae08398e87504af084ef8bb
https://doi.org/10.1038/onc.2015.33
https://doi.org/10.1038/onc.2015.33