Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Rose E Dixon"'
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 1, p e1005906 (2018)
In ventricular myocytes, membrane depolarization during the action potential (AP) causes synchronous activation of multiple L-type CaV1.2 channels (LTCCs), which trigger the release of calcium (Ca2+) from the sarcoplasmic reticulum (SR). This results
Externí odkaz:
https://doaj.org/article/345a2f24d5734d079a047225020f28f6
Autor:
Claudia M Moreno, Rose E Dixon, Sendoa Tajada, Can Yuan, Ximena Opitz-Araya, Marc D Binder, Luis F Santana
Publikováno v:
eLife, Vol 5 (2016)
CaV1.3 channels regulate excitability in many neurons. As is the case for all voltage-gated channels, it is widely assumed that individual CaV1.3 channels behave independently with respect to voltage-activation, open probability, and facilitation. He
Externí odkaz:
https://doaj.org/article/52ec5325693c467f93f042e298bbd824
Autor:
Maartje Westhoff, Silvia G. del Villar, Taylor L. Voelker, Phung N. Thai, Heather C. Spooner, Alexandre D. Costa, Padmini Sirish, Nipavan Chiamvimonvat, Eamonn J. Dickson, Rose E. Dixon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Cardiac dysfunction is a hallmark of aging in humans and mice. Here we report that a two-week treatment to restore youthful Bridging Integrator 1 (BIN1) levels in the hearts of 24-month-old mice rejuvenates cardiac function and substantially
Externí odkaz:
https://doaj.org/article/b0477fcf8cac487d9b9bce149837c365
Autor:
Rose E Dixon, Claudia M Moreno, Can Yuan, Ximena Opitz-Araya, Marc D Binder, Manuel F Navedo, Luis F Santana
Publikováno v:
eLife, Vol 4 (2015)
In the heart, reliable activation of Ca2+ release from the sarcoplasmic reticulum during the plateau of the ventricular action potential requires synchronous opening of multiple CaV1.2 channels. Yet the mechanisms that coordinate this simultaneous op
Externí odkaz:
https://doaj.org/article/284f6017002540988358c675a498745e
Autor:
Jeong Han Lee, Maria C. Perez-Flores, Seojin Park, Hyo Jeong Kim, Yingying Chen, Mincheol Kang, Jennifer Kersigo, Jinsil Choi, Phung N. Thai, Ryan L. Woltz, Dolores Columba Perez-Flores, Guy Perkins, Choong-Ryoul Sihn, Pauline Trinh, Xiao-Dong Zhang, Padmini Sirish, Yao Dong, Wayne Wei Feng, Isaac N. Pessah, Rose E. Dixon, Bernd Sokolowski, Bernd Fritzsch, Nipavan Chiamvimonvat, Ebenezer N. Yamoah
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical t
Externí odkaz:
https://doaj.org/article/2460730132124905aa50c50a2faffa24
Autor:
Maria Casas, Karl D. Murray, Keiko Hino, Nicholas C. Vierra, Sergi Simó, James S. Trimmer, Rose E. Dixon, Eamonn J. Dickson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Lysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the removal of cholesterol from lysosomes, which is then transferr
Externí odkaz:
https://doaj.org/article/8e457916b01b415d80b45482e83ca4c6
Autor:
Henrietta Cserne Szappanos, Helena M. Viola, Danica W. Ito, Seakcheng Lim, Melissa Mangala, Mira Holliday, Samantha Barratt Ross, Christopher Semsarian, Adam Hill, Rose E. Dixon, Livia C. Hool
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Familial hypertrophic cardiomyopathy (FHC) patients are advised to avoid strenuous exercise due to increased risk of arrhythmias. Mice expressing the human FHC-causing mutation R403Q in the myosin heavy chain gene (MYH6) recapitulate the hum
Externí odkaz:
https://doaj.org/article/e1010dcf8ddf4f0397cc92001ff5aa96
Autor:
Maartje Westhoff, Silvia G. del Villar, Taylor L. Voelker, Phung N. Thai, Heather C. Spooner, Alexandre D. Costa, Padmini Sirish, Nipavan Chiamvimonvat, Eamonn J. Dickson, Rose E. Dixon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/c1be2283042645839fbc07427ec467c0
Autor:
Jonathan D. Horvath, Maria Casas, Candice Kutchukian, Sara Creus Sánchez, Melissa R. Pergande, Stephanie M. Cologna, Sergi Simó, Rose E. Dixon, Eamonn J. Dickson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113244- (2023)
Summary: Anomalous aggregation of α-synuclein (α-Syn) is a pathological hallmark of many degenerative synucleinopathies including Lewy body dementia (LBD) and Parkinson’s disease (PD). Despite its strong link to disease, the precise molecular mec
Externí odkaz:
https://doaj.org/article/ff98fe59a9e9430e909a2ae22edbc46d
Autor:
Rose E. Dixon, James S. Trimmer
Publikováno v:
Annual Review of Physiology. 85:217-243
Membrane contact sites between endoplasmic reticulum (ER) and plasma membrane (PM), or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles in organizing diverse forms of Ca2+ signaling as triggered by membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1de058f201f455421928338502ad9e24
https://doi.org/10.1146/annurev-physiol-032122-104610
https://doi.org/10.1146/annurev-physiol-032122-104610