Výsledky vyhledávání - "Rose C. Hadley"

Zinc sequestration by human calprotectin facilitates manganese binding to the bacterial solute-binding proteins PsaA and MntC

Autor: Tomer Rosen, Rose C Hadley, Aaron T Bozzi, Daniel Ocampo, Jason Shearer, Elizabeth M Nolan

Publikováno v: Metallomics

Zinc is an essential transition metal nutrient for bacterial survival and growth but may become toxic when present at elevated levels. The Gram-positive bacterial pathogen Streptococcus pneumoniae is sensitive to zinc poisoning, which results in grow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06925202301a0718e59643192fa3d4df
https://doi.org/10.1093/mtomcs/mfac001

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The copper-linked Escherichia coli AZY operon: Structure, metal binding, and a possible physiological role in copper delivery

Autor: Nurit Livnat-Levanon, Nir Ben-Tal, Elena Vigonsky, Amy C. Rosenzweig, Rose C. Hadley, Jessica Rose, Oded Lewinson, Gal Masrati, Daniel Zhitnitsky

Publikováno v: The Journal of Biological Chemistry

The Escherichia coli yobA–yebZ–yebY (AZY) operon encodes the proteins YobA, YebZ, and YebY. YobA and YebZ are homologs of the CopC periplasmic copper-binding protein and the CopD putative copper importer, respectively, whereas YebY belongs to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba8ff10957a16317cb12cd0ca39a6a7
http://europepmc.org/articles/PMC8689200

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Biochemical and Spectroscopic Observation of Mn(II) Sequestration from Bacterial Mn(II) Transport Machinery by Calprotectin

Autor: Elizabeth M. Nolan, Derek M. Gagnon, Yu Gu, R. David Britt, Toshiki G. Nakashige, Megan Brunjes Brophy, Rose C. Hadley

Publikováno v: Journal of the American Chemical Society, vol 140, iss 1

Human calprotectin (CP, S100A8/S100A9 oligomer) is a metal-sequestering host-defense protein that prevents bacterial acquisition of Mn(II). In this work, we investigate Mn(II) competition between CP and two solute-binding proteins that Staphylococcus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c7e174a1f75870c1eb5a77b71101d3
https://doi.org/10.1021/jacs.7b11207

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Transition metals at the host–pathogen interface: how Neisseria exploit human metalloproteins for acquiring iron and zinc

Autor: Elizabeth M. Nolan, Wilma Neumann, Rose C. Hadley

Publikováno v: PMC

Transition metals are essential nutrients for all organisms and important players in the host-microbe interaction. During bacterial infection, a tug-of-war between the host and microbe for nutrient metals occurs: the host innate immune system respond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc799338fbcc4e2f5ffb9bebbb19bc1
https://doi.org/10.1042/ebc20160084

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Murine Calprotectin Coordinates Mn(II) at a Hexahistidine Site with Ca(II)-Dependent Affinity

Autor: Elizabeth M. Nolan, Rose C. Hadley, Andrew Ozarowski, R. David Britt, Derek M. Gagnon

Publikováno v: Inorganic chemistry, vol 58, iss 20
Inorg Chem

Manganese is an essential metal ion that bacterial pathogens need to acquire from the vertebrate host during infection. In the mammalian nutritional immunity strategy to combat bacterial infection, the host restricts bacterial access to Mn(II) by seq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e20d8deb56020873d944342645f387
https://escholarship.org/uc/item/47n1q09j

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High-Field EPR Spectroscopic Characterization of Mn(II) Bound to the Bacterial Solute-Binding Proteins MntC and PsaA

Autor: Elizabeth M. Nolan, Rose C. Hadley, Derek M. Gagnon, Andrew Ozarowski, R. David Britt

Publikováno v: J Phys Chem B
The journal of physical chemistry. B, vol 123, iss 23

During infection, the bacterial pathogens Staphylococcus aureus and Streptococcus pneumoniae employ ATP-binding cassette (ABC) transporters to acquire Mn(II), an essential nutrient, from the host environment. Staphylococcal MntABC and streptococcal P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afee44d782914ab8d82bab36b3028e58
https://pubmed.ncbi.nlm.nih.gov/31117618

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Preparation and Iron Redox Speciation Study of the Fe(II)-Binding Antimicrobial Protein Calprotectin

Autor: Rose C. Hadley, Elizabeth M. Nolan

Publikováno v: Methods in Molecular Biology ISBN: 9781493990290

Calprotectin (CP, S100A8/S100A9 heterooligomer) is an abundant metal-sequestering host-defense protein expressed by neutrophils, other white blood cells, and epithelial cells. The apo protein is a S100A8/S100A9 heterodimer that contains two sites for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a31970b2b535fff9cf80d4d3300b38
https://doi.org/10.1007/978-1-4939-9030-6_25

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Initial Biochemical and Functional Evaluation of Murine Calprotectin Reveals Ca(II)-Dependence and Its Ability to Chelate Multiple Nutrient Transition Metal Ions

Autor: Elizabeth M. Nolan, Yu Gu, Rose C. Hadley

Calprotectin (CP) is an abundant host-defense protein that contributes to the metal-withholding innate immune response by sequestering nutrient metal ions from microbial pathogens in the extracellular space. Over the past decade, murine models of inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c7d59f37b76e7a5b856d9968e2188a
https://europepmc.org/articles/PMC5953840/

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Transition metals at the host-pathogen interface: how

Autor: Wilma, Neumann, Rose C, Hadley, Elizabeth M, Nolan

Publikováno v: Essays in biochemistry. 61(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9f795ce669077c0c0d79be66102aac7
https://pubmed.ncbi.nlm.nih.gov/28487398

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