Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Rose Barham"'
Autor:
John Schafer, Michael A. Plotkin, Xiaoyuan Ding, Todd Wisialowski, Meghan Maloney, Judith C. Hamel, Sandra P. McCurdy, Joel R. Hardink, Christopher Zook, Steven M. Finegan, Chakrapani Subramanyam, Lori Brennan, Rose Barham, Steven J. Brickner, Daniel P. Uccello, Dale Gordon Mcleod, Kwansik Yoon, Michael D. Huband, Jeffrey M. Casavant, Usa Reilly, Mark J. Mitton-Fry, Anthony Marfat, Richard P. Zaniewski, Gregory G. Stone, Thuy Hoang
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(15)
Novel (non-fluoroquinolone) inhibitors of bacterial type II topoisomerases (NBTIs) are an emerging class of antibacterial agents. We report an optimized series of cyclobutylaryl-substituted NBTIs. Compound 14 demonstrated excellent activity both in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f8fda88844e0a432984aaa4ef3346a
https://pubmed.ncbi.nlm.nih.gov/28610977
https://pubmed.ncbi.nlm.nih.gov/28610977
Autor:
Rose Barham, Thuy Hoang, Jeremy T. Starr, Jennifer A. Young, M. Megan Lemmon, Joseph Penzien, Mark J. Mitton-Fry, Thomas M. Harris, Antonia A. Nikitenko, Brian S. Gerstenberger, Sandra P. McCurdy, Veerabahu Shanmugasundaram, Lisa Mullins, Joel R. Hardink, Jeffrey M. Casavant, Eric S. Marr, Jian Lin, Seungil Han, Joel T. Arcari, John P. Mueller, Brandon P. Schuff, Mark S. Plummer, Craig J. McPherson, Michael D. Huband, Mark C. Noe, Manjinder S. Lall, Richard P. Zaniewski, Chao Li, Matthew Frank Brown, Jianmin Sun, Eric B. McElroy, Andrew P. Tomaras
Publikováno v:
Journal of Medicinal Chemistry. 56:5541-5552
Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa , Klebsiella p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8694e6ad3d6cdb04a7acacaafb875122
https://doi.org/10.1021/jm400560z
https://doi.org/10.1021/jm400560z
Autor:
Lisa Mullins, Daniel P. Uccello, Justin I. Montgomery, Ye Che, John P. O'Donnell, Mark S. Plummer, Joseph A. Abramite, Seung Won Chung, Loren M. Price, Mark C. Noe, Laura A. McAllister, Rose Barham, Mark J. Mitton-Fry, Andrew P. Tomaras, Usa Reilly, Matthew Frank Brown, Jinshan M. Chen, Joseph Penzien, Carol A. Menard, Veerabahu Shanmugasundaram, Robert M. Oliver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6832-6838
The synthesis and antibacterial activity of heterocyclic methylsulfone hydroxamates is presented. Compounds in this series are potent inhibitors of the LpxC enzyme, a key enzyme involved in the production of lipopolysaccharide (LPS) found in the oute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5698632622184881fc9d9e040335da17
https://doi.org/10.1016/j.bmcl.2012.09.058
https://doi.org/10.1016/j.bmcl.2012.09.058
Autor:
Matthew David Doroski, Joel T. Arcari, Mark S. Plummer, Andrea Marra, Thomas M. Harris, Justin I. Montgomery, Usa Reilly, Carol A. Menard, Michael D. Huband, Anthony Marfat, Jinshan Michael Chen, Christy Thoma, Karen L. Leach, John P. O'Donnell, Seung Won Chung, Loren M. Price, Joseph A. Abramite, Charlene R. Desbonnet, Eric B. McElroy, Veerabahu Shanmugasundaram, Michael Melnick, Shenping Liu, Matthew Frank Brown, Mark C. Noe, Joseph S. Warmus, Juntyma J. Engtrakul, Daniel P. Uccello, Donn G. Wishka, Robert M. Oliver, Rose Barham, Joseph Penzien, Jonathan L. Doty, John D. Knafels, Ye Che, Lisa Mullins, Elizabeth M. Collantes
Publikováno v:
Journal of medicinal chemistry. 55(2)
In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcf3eac90ca18e20f4de1258188335d
https://pubmed.ncbi.nlm.nih.gov/22175825
https://pubmed.ncbi.nlm.nih.gov/22175825