Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rose B. Creed"'
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)
Abstract Genetic and neuropathological evidence strongly implicates aberrant forms of α-synuclein in neurodegeneration. Antibodies specific for α-synuclein phosphorylated at serine 129 (pS129) are selective for the pathological protein aggregates t
Externí odkaz:
https://doaj.org/article/32492b2590f04bc79c6937d8dab78d2f
Autor:
Adeel A. Memon, Micah E. Bagley, Rose B. Creed, Amy W. Amara, Matthew S. Goldberg, Lori L. McMahon
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Loss of function mutations in PARK6, the gene that encodes the protein PTEN-induced kinase 1 (PINK1), cause autosomal recessive familial Parkinson’s disease (PD). While PD is clinically diagnosed by its motor symptoms, recent studies point to the i
Externí odkaz:
https://doaj.org/article/449ffa7e71cd4f848c7743fdcb5a8336
Autor:
Rose B. Creed, Rosalinda C. Roberts, Charlene B. Farmer, Lori L. McMahon, Matthew S. Goldberg
Publikováno v:
Neurobiology of Disease, Vol 150, Iss , Pp 105246- (2021)
Loss-of-function PTEN Induced Kinase 1 (PINK1) mutations cause early-onset familial Parkinson's disease (PD) with similar clinical and neuropathological characteristics as idiopathic PD. While Pink1 knockout (KO) rats have mitochondrial dysfunction,
Externí odkaz:
https://doaj.org/article/4453aa85f5e347e6a224e273653d972f
Autor:
Rose B. Creed, Matthew S. Goldberg
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2019)
Mutations in PTEN induced kinase 1 (PINK1) cause autosomal recessive Parkinson’s disease (PD). The main pathological hallmarks of PD are loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of protein aggregates cont
Externí odkaz:
https://doaj.org/article/a13b3ad0334548b09d1b621a0cc241cd
Autor:
Rose B. Creed, Lori L. McMahon, Rosalinda C. Roberts, Charlene B. Farmer, Matthew S. Goldberg
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 150, Iss, Pp 105246-(2021)
Neurobiology of Disease, Vol 150, Iss, Pp 105246-(2021)
Loss-of-function PTEN Induced Kinase 1 (PINK1) mutations cause early-onset familial Parkinson's disease (PD) with similar clinical and neuropathological characteristics as idiopathic PD. While Pink1 knockout (KO) rats have mitochondrial dysfunction,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75df2c18da5f3c700b694986f9b6a512
https://europepmc.org/articles/PMC7908817/
https://europepmc.org/articles/PMC7908817/
Autor:
Sandeep Kumar Barodia, Elijah K Quinones, Rita M. Cowell, Laura J. McMeekin, Rose B. Creed, Matthew S. Goldberg
Publikováno v:
NPJ Parkinson's Disease
npj Parkinson's Disease, Vol 5, Iss 1, Pp 1-9 (2019)
npj Parkinson's Disease, Vol 5, Iss 1, Pp 1-9 (2019)
Loss-of-function mutations in PINK1 are causally linked to recessively inherited Parkinson’s disease (PD), with marked loss of dopaminergic neurons in the substantia nigra that are required for normal movement. PINK1 is a nuclear-encoded mitochondr
Autor:
Matthew S. Goldberg, Rose B. Creed
Publikováno v:
Neuroscience
The main neuropathological hallmarks of Parkinson’s disease (PD) are loss of dopaminergic neurons in the substantia nigra and intraneuronal protein aggregates immunoreactive for α-synuclein phosphorylated at serine 129 (pS129). Most cases of PD ar
Autor:
Matthew S. Goldberg, Rose B. Creed
Publikováno v:
Movement Disorders. 33:717-729
Preclinical research on Parkinson's disease has relied heavily on mouse and rat animal models. Initially, PD animal models were generated primarily by chemical neurotoxins that induce acute loss of dopaminergic neurons in the substantia nigra. On the
Autor:
Bradford Casey, Rose B. Creed, Matthew S. Goldberg, Liliana Menalled, Holden B. Janssens, Isaac Veinbergs, Kuldip D. Dave, Marieke van der Hart, Arash Rassoulpour
Publikováno v:
Neuroscience. 409
Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is characterized by the loss of neurons in the substantia nigra that project to the striatum and release dopamine (DA), which is required for normal movement. Common
Autor:
Rose B, Creed, Matthew S, Goldberg
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 33(5)
Preclinical research on Parkinson's disease has relied heavily on mouse and rat animal models. Initially, PD animal models were generated primarily by chemical neurotoxins that induce acute loss of dopaminergic neurons in the substantia nigra. On the