Tumour Infiltrating Lymphocytes (TILs) and immune composition in breast cancer patients from Kenya: Spatial distributions and associations with risk factors and tumour characteristics

Autor: Shahin Sayed, Hela Koka, Mustapha Abubakar, Kevin Gardner, Roberto Salgado, Zahir Moloo, Ambar Beatriz Caban-Ureña, Daniel Rosen, Patricia Castro, Mansoor Saleh, Asim Jamal Shaikh, Jasmit Shah, Jonine Figueroa, Francis Makokha, Hien Khanh Ha, Zhong Wang, Pumza Magangane, Richard Naidoo, Veronica Ngundo, Xiaohong Rose Yang, Dhirendra Govender

Publikováno v: Breast Cancer Research and Treatment. 199:401-413

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e276d98163ec150dc15f658f02b18c4
https://doi.org/10.1007/s10549-023-06921-3

Data from A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women

Autor: Sara Lindström, Jenny Chang-Claude, Peter Kraft, Li Hsu, Roger L. Milne, Douglas F. Easton, Håkan Olsson, Sophia Wang, James V. Lacey, Nick Orr, Anthony J. Swerdlow, Jack A. Taylor, Dale P. Sandler, Alicja Wolk, Kamila Czene, Per Hall, Anthony Howell, D. Gareth Evans, Rose Yang, Thomas Ahearn, Jonine Figueroa, Montserrat García-Closas, Heather Eliassen, Rulla Tamimi, Cheng Peng, Michael I. Love, Melissa A. Troester, Jirong Long, Wei Zheng, Mark S. Goldberg, Jacques Simard, Stacey Winham, Christopher Scott, Gertraud Maskarinec, Christopher A. Haiman, Graham G. Giles, Heiko Becher, Audrey Jung, Veli-Matti Kosma, Arto Mannermaa, Sabine Behrens, Wing-Yee Lo, Reiner Hoppe, Volker Arndt, Hermann Brenner, Rudolf Kaaks, Federico Canzian, James M. Hodge, Lauren R. Teras, Thérèse Truong, Pascal Guénel, Kristan Aronson, Rachel A. Murphy, Rana Shibli, Gad Rennert, Jennifer Stone, Laura E. Beane Freeman, Stella Koutros, Melissa C. Southey, John L. Hopper, Paul D.P. Pharoah, Kyriaki Michailidou, Qin Wang, Michael Lush, Alison M. Dunning, Joe Dennis, Manjeet K. Bolla, Yu-Ru Su, Pooja Middha Kapoor, Hongjie Chen, Xiaoliang Wang

Genome-wide association studies (GWAS) have identified more than 200 susceptibility loci for breast cancer, but these variants explain less than a fifth of the disease risk. Although gene–environment interactions have been proposed to account for s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f64dc05078ca7e1e1d9c4a73181548f
https://doi.org/10.1158/2767-9764.c.6550751.v1

Supplementary Figure 1 from A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women

Autor: Sara Lindström, Jenny Chang-Claude, Peter Kraft, Li Hsu, Roger L. Milne, Douglas F. Easton, Håkan Olsson, Sophia Wang, James V. Lacey, Nick Orr, Anthony J. Swerdlow, Jack A. Taylor, Dale P. Sandler, Alicja Wolk, Kamila Czene, Per Hall, Anthony Howell, D. Gareth Evans, Rose Yang, Thomas Ahearn, Jonine Figueroa, Montserrat García-Closas, Heather Eliassen, Rulla Tamimi, Cheng Peng, Michael I. Love, Melissa A. Troester, Jirong Long, Wei Zheng, Mark S. Goldberg, Jacques Simard, Stacey Winham, Christopher Scott, Gertraud Maskarinec, Christopher A. Haiman, Graham G. Giles, Heiko Becher, Audrey Jung, Veli-Matti Kosma, Arto Mannermaa, Sabine Behrens, Wing-Yee Lo, Reiner Hoppe, Volker Arndt, Hermann Brenner, Rudolf Kaaks, Federico Canzian, James M. Hodge, Lauren R. Teras, Thérèse Truong, Pascal Guénel, Kristan Aronson, Rachel A. Murphy, Rana Shibli, Gad Rennert, Jennifer Stone, Laura E. Beane Freeman, Stella Koutros, Melissa C. Southey, John L. Hopper, Paul D.P. Pharoah, Kyriaki Michailidou, Qin Wang, Michael Lush, Alison M. Dunning, Joe Dennis, Manjeet K. Bolla, Yu-Ru Su, Pooja Middha Kapoor, Hongjie Chen, Xiaoliang Wang

Quantile-Quantile plot (Q-Q plot) of the aMiSTi p-values for each set of the GxE interactions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf81b5ea782cb0915292a498de4d790
https://doi.org/10.1158/2767-9764.22544801

Tumor-Associated Stromal Cellular Density as a Predictor of Recurrence and Mortality in Breast Cancer: Results from Ethnically Diverse Study Populations

Autor: Hela Koka, Mustapha Abubakar, Jolanta Lissowska, Scott M. Lawrence, Montserrat Garcia-Closas, Jianming Ying, Ning Lyu, Jonine D. Figueroa, Xiaohong Rose Yang, Jing Zhang, Karun Mutreja, Changyuan Guo, Thomas U. Ahearn

Publikováno v: Cancer Epidemiol Biomarkers Prev

Purpose: Tumor-associated stroma is comprised of fibroblasts, tumor-infiltrating lymphocytes (TIL), macrophages, endothelial cells, and other cells that interactively influence tumor progression through inflammation and wound repair. Although gene-ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d55d9c46db9442afc3dd7372f489960
https://doi.org/10.1158/1055-9965.epi-21-0055

A genome-wide gene-based gene-environment interaction study of breast cancer in more than 90,000 women

Autor: Xiaoliang Wang, Hongjie Chen, Pooja Middha Kapoor, Yu-Ru Su, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Michael Lush, Qin Wang, Kyriaki Michailidou, Paul D.P. Pharoah, John L. Hopper, Melissa C. Southey, Stella Koutros, Laura E. Beane Freeman, Jennifer Stone, Gad Rennert, Rana Shibli, Rachel A. Murphy, Kristan Aronson, Pascal Guénel, Thérèse Truong, Lauren R. Teras, James M. Hodge, Federico Canzian, Rudolf Kaaks, Hermann Brenner, Volker Arndt, Reiner Hoppe, Wing-Yee Lo, Sabine Behrens, Arto Mannermaa, Veli-Matti Kosma, Audrey Jung, Heiko Becher, Graham G. Giles, Christopher A. Haiman, Gertraud Maskarinec, Christopher Scott, Stacey Winham, Jacques Simard, Mark S. Goldberg, Wei Zheng, Jirong Long, Melissa A. Troester, Michael I. Love, Cheng Peng, Rulla Tamimi, Heather Eliassen, Montserrat García-Closas, Jonine Figueroa, Thomas Ahearn, Rose Yang, D. Gareth Evans, Anthony Howell, Per Hall, Kamila Czene, Alicja Wolk, Dale P. Sandler, Jack A. Taylor, Anthony J. Swerdlow, Nick Orr, James V. Lacey, Sophia Wang, Håkan Olsson, Douglas F. Easton, Roger L. Milne, Li Hsu, Peter Kraft, Jenny Chang-Claude, Sara Lindström

Publikováno v: Wang, X, Chen, H, Middha Kapoor, P, Su, Y-R, Bolla, M K, Dennis, J, Dunning, A M, Lush, M, Wang, Q, Michailidou, K, Pharoah, P D P, Hopper, J L, Southey, M C, Koutros, S, Beane Freeman, L E, Stone, J, Rennert, G, Shibli, R, Murphy, R A, Aronson, K, Guénel, P, Truong, T, Teras, L R, Hodge, J M, Canzian, F, Kaaks, R, Brenner, H, Arndt, V, Hoppe, R, Lo, W-Y, Behrens, S, Mannermaa, A, Kosma, V-M, Jung, A, Becher, H, Giles, G G, Haiman, C A, Maskarinec, G, Scott, C, Winham, S, Simard, J, Goldberg, M S, Zheng, W, Long, J, Troester, M A, Love, M I, Peng, C, Tamimi, R, Eliassen, H, García-Closas, M, Figueroa, J, Ahearn, T, Yang, R, Evans, D G, Howell, A, Hall, P, Czene, K, Wolk, A, Sandler, D P, Taylor, J A, Swerdlow, A J, Orr, N, Lacey, J V, Wang, S, Olsson, H, Easton, D F, Milne, R L, Hsu, L, Kraft, P, Chang-Claude, J & Lindström, S 2022, ' A genome-wide gene-based gene-environment interaction study of breast cancer in more than 90,000 women ', Cancer research communications, vol. 2, no. 4, pp. 211-219 . https://doi.org/10.1158/2767-9764.CRC-21-0119
Cancer Res Commun
Wang, X, Chen, H, Kapoor, P M, Su, Y-R, Bolla, M K, Dennis, J, Dunning, A M, Lush, M, Wang, Q, Michailidou, K, Pharoah, P D P, Hopper, J L, Southey, M C, Koutros, S, Freeman, L E B, Stone, J, Rennert, G, Shibli, R, Murphy, R A, Aronson, K, Guénel, P, Truong, T, Teras, L R, Hodge, J M, Canzian, F, Kaaks, R, Brenner, H, Arndt, V, Hoppe, R, Lo, W-Y, Behrens, S, Mannermaa, A, Kosma, V-M, Jung, A, Becher, H, Giles, G G, Haiman, C A, Maskarinec, G, Scott, C, Winham, S, Simard, J, Goldberg, M S, Zheng, W, Long, J, Troester, M A, Love, M I, Peng, C, Tamimi, R, Eliassen, H, García-Closas, M, Figueroa, J, Ahearn, T, Yang, R, Evans, D G, Howell, A, Hall, P, Czene, K, Wolk, A, Sandler, D P, Taylor, J A, Swerdlow, A J, Orr, N, Lacey, J V, Wang, S, Olsson, H, Easton, D F, Milne, R L, Hsu, L, Kraft, P, Chang-Claude, J & Lindström, S 2022, ' A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women ', Cancer Research Communications, vol. 2, no. 4, pp. 211-219 . https://doi.org/10.1158/2767-9764.crc-21-0119
Wang, X, Chen, H, Middha Kapoor, P, Su, Y-R, Bolla, M K, Dennis, J, Dunning, A M, Lush, M, Wang, Q, Michailidou, K, Pharoah, P D P, Hopper, J L, Southey, M C, Koutros, S, Beane Freeman, L E, Stone, J, Rennert, G, Shibli, R, Murphy, R A, Aronson, K, Guénel, P, Truong, T, Teras, L R, Hodge, J M, Canzian, F, Kaaks, R, Brenner, H, Arndt, V, Hoppe, R, Behrens, S, Mannermaa, A, Kosma, V-M, Jung, A, Becher, H, Giles, G G, Haiman, C A, Maskarinec, G, Winham, S, Simard, J, Goldberg, M S, Zheng, W, Long, J, Troester, M A, Love, M I, Tamimi, R, Eliassen, H, García-Closas, M, Figueroa, J, Ahearn, T, Yang, R, Evans, D G, Howell, A, Hall, P, Czene, K, Wolk, A, Sandler, D P, Taylor, J A, Swerdlow, A J, Orr, N, Lacey, J V, Wang, S, Olsson, H, Easton, D F, Milne, R L, Hsu, L, Kraft, P, Chang-Claude, J & Lindström, S 2022, ' A genome-wide gene-based gene-environment interaction study of breast cancer in more than 90,000 women ', Cancer Research Communications, vol. 2, no. 4, pp. 211-219 . https://doi.org/10.1158/2767-9764.CRC-21-0119

Genome-wide association studies (GWAS) have identified more than 200 susceptibility loci for breast cancer, but these variants explain less than a fifth of the disease risk. Although gene–environment interactions have been proposed to account for s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22bc4fc3d3e000bcbe2618f0b30911cd
https://hdl.handle.net/20.500.11820/633d091d-4fac-4b0d-8eec-b51042a74fe6