The great evolutionary divide: Two genomic systems biologies of aging

Autor: Rose, MR, Cabral, LG, Philips, MA, Phung, KH, Mueller, LD, Greer, LF

Publikováno v: Rose, MR; Cabral, LG; Philips, MA; Phung, KH; Mueller, LD; & Greer, LF. (2014). The great evolutionary divide: Two genomic systems biologies of aging. Interdisciplinary Topics in Gerontology, 40, 63-73. doi: 10.1159/000364930. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5k02n871

© 2015 S. Karger AG, Basel. There is not one systems biology of aging, but two. Though aging can evolve in either sexual or asexual species when there is asymmetric reproduction, the evolutionary genetics of aging in species with frequent sexual rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::3668cb40fd360031df00695b761589be
http://www.escholarship.org/uc/item/5k02n871

Natural Radiation Induced Developmental Disability: An Avian Model

Autor: Jeni Chandar Padua, Basil Rose Mr

Publikováno v: Nature Precedings

Radiation exposure during gestation causes mutation in the fetus leading to birth defects in the newborn. On a survey of the coastal villages of Kanyakumari District, Tamilnadu, India, high levels of background radiation were detected, which was sugg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d689adcb27c8419c3054598a4dbf00e
https://doi.org/10.1038/npre.2011.6191.1

Using experimental evolution to study the physiological mechanisms of desiccation resistance in Drosophila melanogaster

Autor: Archer, MA, Bradley, TJ, Mueller, LD, Rose, MR

Publikováno v: Archer, MA; Bradley, TJ; Mueller, LD; & Rose, MR. (2007). Using experimental evolution to study the physiological mechanisms of desiccation resistance in Drosophila melanogaster. Physiological and Biochemical Zoology, 80(4), 386-398. doi: 10.1086/518354. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8w10j62v

Data from populations undergoing experimental evolution can be used to make comparisons between physiologically differentiated populations and to determine evolutionary trajectories. Comparisons of long-established laboratory populations of Drosophil

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http://www.escholarship.org/uc/item/8w10j62v

Testing whether male age or high nutrition causes the cessation of reproductive aging in female Drosophila melanogaster populations

Autor: Rauser, CL, Hong, JS, Cung, MB, Pham, KM, Mueller, LD, Rose, MR

Publikováno v: Rauser, CL; Hong, JS; Cung, MB; Pham, KM; Mueller, LD; & Rose, MR. (2005). Testing whether male age or high nutrition causes the cessation of reproductive aging in female Drosophila melanogaster populations. Rejuvenation Research, 8(2), 86-95. doi: 10.1089/rej.2005.8.86. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4pk98701

Fecundity seems to stop declining and plateaus at low levels very late in Drosophila melanogaster populations. Here we test whether this apparent cessation of reproductive aging by a population, herein referred to as fecundity plateaus, is robust und

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http://www.escholarship.org/uc/item/4pk98701

Ageing and immortality

Autor: Rose, MR, Mueller, LD

Publikováno v: Rose, MR; & Mueller, LD. (2000). Ageing and immortality. Philosophical Transactions of the Royal Society B: Biological Sciences, 355(1403), 1657-1662. doi: 10.1098/rstb.2000.0728. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2cj014sd

The concept of the force of natural selection was developed to explain the evolution of ageing. After ageing, however, comes a period in which mortality rates plateau and some individual organisms could, in theory, live forever. This late-life immort

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http://www.escholarship.org/uc/item/2cj014sd