Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Rosario Osta"'
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 377 (2024)
Amyotrophic lateral sclerosis (ALS) that comprises sporadic (sALS) and familial (fALS) cases, is a devastating neurodegenerative disorder characterized by progressive degeneration of motor neurons, leading to muscle atrophy and various clinical manif
Externí odkaz:
https://doaj.org/article/e578f381a68d465a9fcba693464bb08e
Autor:
Daniel Borrego-Hernández, Juan Francisco Vázquez-Costa, Raúl Domínguez-Rubio, Laura Expósito-Blázquez, Elena Aller, Ariadna Padró-Miquel, Pilar García-Casanova, María J. Colomina, Cristina Martín-Arriscado, Rosario Osta, Pilar Cordero-Vázquez, Jesús Esteban-Pérez, Mónica Povedano-Panadés, Alberto García-Redondo
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 356 (2024)
Intermediate CAG expansions in the gene ataxin-2 (ATXN2) are a known risk factor for ALS, but little is known about their role in FTD risk. Moreover, their contribution to the risk and phenotype of patients might vary in populations with different ge
Externí odkaz:
https://doaj.org/article/6e52c9e0d7754724821309829d1f7d65
Autor:
Laura Moreno-Martinez, Sofía Macías-Redondo, Mark Strunk, María Isabel Guillén-Antonini, Christian Lunetta, Claudia Tarlarini, Silvana Penco, Ana Cristina Calvo, Rosario Osta, Jon Schoorlemmer
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1549 (2024)
Retroviral reverse transcriptase activity and the increased expression of human endogenous retroviruses (HERVs) are associated with amyotrophic lateral sclerosis (ALS). We were interested in confirming HERVK overexpression in the ALS brain, its use a
Externí odkaz:
https://doaj.org/article/f0c2027758474a9d9b58e5c3345228fb
Analysis of Plasma-Derived Exosomal MicroRNAs as Potential Biomarkers for Canine Idiopathic Epilepsy
Autor:
Mireya García-Gracia, Laura Moreno-Martinez, Adelaida Hernaiz, Sebastián Usón, Jon Moral, David Sanz-Rubio, Pilar Zaragoza, Jorge Palacio, Belén Rosado, Rosario Osta, Sylvia García-Belenguer, Inmaculada Martín Burriel
Publikováno v:
Animals, Vol 14, Iss 2, p 252 (2024)
Epilepsy is one of the most prevalent complex neurological diseases in both the canine and human species, with the idiopathic form as its most common diagnosis. MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a role in gene regulation
Externí odkaz:
https://doaj.org/article/41687da3f2df49769aa8ebac7c4e8e2f
Autor:
Rafael Gonzalo-Gobernado, Laura Moreno-Martínez, Paz González, Xose Manuel Dopazo, Ana Cristina Calvo, Isabel Pidal-Ladrón de Guevara, Elisa Seisdedos, Rodrigo Díaz-Muñoz, Britt Mellström, Rosario Osta, José Ramón Naranjo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15783 (2023)
The interaction of the activating transcription factor 6 (ATF6), a key effector of the unfolded protein response (UPR) in the endoplasmic reticulum, with the neuronal calcium sensor Downstream Regulatory Element Antagonist Modulator (DREAM) is a pote
Externí odkaz:
https://doaj.org/article/79ba1bac1a3c4fa08312a5dc7b73ceca
Autor:
Cristina González-Mingot, Francisco Javier Miana-Mena, Pedro José Iñarrea, Cristina Iñiguez, José Luis Capablo, Rosario Osta, Anna Gil-Sánchez, Luis Brieva, Pilar Larrodé
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 10, p 3560 (2023)
Background: Amyotrophic lateral sclerosis (ALS) is a multisystemic, progressive, neurodegenerative disorder. Despite it being generally fatal within a period of 2–4 years, it is highly heterogeneous; as a result, survival periods may vary greatly a
Externí odkaz:
https://doaj.org/article/67328b9de1fa4f15963587621cf88d1a
Autor:
Laura Moreno-Martinez, Llipsy Santiago, Miriam de la Torre, Ana Cristina Calvo, Julián Pardo, Rosario Osta
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13554 (2022)
Granzyme A (gzmA), a serine protease involved in the modulation of the inflammatory immune response, is found at an elevated level in the serum from ALS patients. However, the influence of gzmA on the progression of ALS remains unclear. The aim of ou
Externí odkaz:
https://doaj.org/article/1d32429bc56747c4af048ff085c4bddf
Autor:
Anna Martínez-Muriana, Diego Pastor, Renzo Mancuso, Amaya Rando, Rosario Osta, Salvador Martínez, Rubèn López-Vales, Xavier Navarro
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-11 (2020)
Abstract Background The simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging disease. Here, we studied two different cell therapy protocols to protect both central and peri
Externí odkaz:
https://doaj.org/article/8d33161732da499ba5e50cfa37ffd723
Autor:
Ana C Calvo, Laura Moreno, Leticia Moreno, Janne M Toivonen, Raquel Manzano, Nora Molina, Miriam de la Torre, Tresa López, Francisco J Miana-Mena, María J Muñoz, Pilar Zaragoza, Pilar Larrodé, Alberto García-Redondo, Rosario Osta
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 6, Pp 988-995 (2020)
Among collagen members in the collagen superfamily, type XIX collagen has raised increasing interest in relation to its structural and biological roles. Type XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member, one mai
Externí odkaz:
https://doaj.org/article/318993b623d4493aaa934b34375181b7
Autor:
Ana Cristina Calvo, Inés Valledor-Martín, Laura Moreno-Martínez, Janne Markus Toivonen, Rosario Osta
Publikováno v:
Genes, Vol 13, Iss 5, p 865 (2022)
The gut microbiota is able to modulate the development and homeostasis of the central nervous system (CNS) through the immune, circulatory, and neuronal systems. In turn, the CNS influences the gut microbiota through stress responses and at the level
Externí odkaz:
https://doaj.org/article/8e0529c760a04114a17229d6c31e312b