Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Rosario LoBrutto"'
Publikováno v:
Journal of Chromatography A. 1318:112-121
There are several spectroscopic techniques such as IR and CD, that allow for analyzing protein secondary structure in solution. However, a majority of these techniques require using purified protein, concentrated enough in the solution, to produce a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab04cefb670aff42fdb1cfeeb3192e2
https://doi.org/10.1016/j.chroma.2013.09.067
https://doi.org/10.1016/j.chroma.2013.09.067
Autor:
Alexey A. Makarov, Paul Karpinski, Christos Christodoulatos, Rosario LoBrutto, A. K. Ganguly, Yuri Kazakevich
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 35:407-427
The goal of this study was to investigate the effect of pressure modulation on the retention, selectivity, and peak efficiency of proteins and small basic and neutral molecules using reversed-phase liquid chromatography. A backpressure restrictor was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2161c9b4473694abad41939ff1d5d082
https://doi.org/10.1080/10826076.2011.601494
https://doi.org/10.1080/10826076.2011.601494
Publikováno v:
Journal of Pharmaceutical Sciences. 99:5030-5039
The purpose of this study was to determine the cause for flowability difference observed during drug product processing when different Metformin HCl drug substance batches of varying age were used. It was found that the lead time (age) between the fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1efb1d021d872da15cc7abdf567488
https://doi.org/10.1002/jps.22207
https://doi.org/10.1002/jps.22207
Publikováno v:
Journal of Hazardous Materials. 162:1034-1040
Ultra high-performance liquid chromatography (UHPLC) utilizes columns packed with sub-2-mum stationary-phase particles and allows operation with pressures of up to 15,000 psi to yield increased resolution, speed, and sensitivity versus conventional H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b1a94599bc94d25fab51ea516f161c
https://doi.org/10.1016/j.jhazmat.2008.05.157
https://doi.org/10.1016/j.jhazmat.2008.05.157
Autor:
Richard Victor Vivilecchia, Rosario LoBrutto, Anton Jerkovich, Yuri Kazakevich, Raymond McGill, Alexey A. Makarov
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 31:2253-2285
The pharmaceutical industry today is driven to create new, more efficient ways to discover, develop, deliver and monitor drugs. Pharmaceutical companies are being faced with major challenges in reducing drug discovery and development timelines. Autom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2868c13d8274d8661086e6a2c4d389d0
https://doi.org/10.1080/10826070802279467
https://doi.org/10.1080/10826070802279467
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 31:1533-1567
The separation of basic compounds can be challenging and the use of inorganic mobile phase additives have been successfully used in chromatographic methods development. About fifteen years ago the role of these additives as ion-interaction agents for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1837659e3fd1601098b36cc846d32af
https://doi.org/10.1080/10826070802125918
https://doi.org/10.1080/10826070802125918
Publikováno v:
Analytica Chimica Acta. 611:143-150
Near-infrared calibration models were developed for the determination of content uniformity of pharmaceutical tablets containing 29.4% drug load for two dosage strengths (X and Y). Both dosage strengths have a circular geometry and the only differenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d6f1418339d47fbc668876d4d2439b
https://doi.org/10.1016/j.aca.2008.02.016
https://doi.org/10.1016/j.aca.2008.02.016
Publikováno v:
Vibrational Spectroscopy. 46:128-134
This paper presents an application of near-infrared (NIR) multivariate calibration for the determination of content uniformity of pharmaceutical tablets. Data used in this study were acquired from 3 NIR instruments obtained from 2 different vendors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd1561204826fd357ff4134dcbf88b0d
https://doi.org/10.1016/j.vibspec.2007.11.004
https://doi.org/10.1016/j.vibspec.2007.11.004
Publikováno v:
Organic Process Research & Development. 9:670-676
The enantioseparation process is of great interest to the pharmaceutical industry since more than 50% of the pharmaceutically active ingredients are known to be chiral and one enantiomer is usually preferred over the racemic mixture. Crystallization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dc9eedb0a8cb9246d9358298a13d4d
https://doi.org/10.1021/op0501038
https://doi.org/10.1021/op0501038