Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Rosario Gulino"'
Autor:
Chiara Prinzi, Anna Kostenko, Gioacchino de Leo, Rosario Gulino, Giampiero Leanza, Antonella Caccamo
Publikováno v:
Biology, Vol 12, Iss 9, p 1264 (2023)
Noradrenaline (NA) depletion occurs in Alzheimer’s disease (AD); however, its relationship with the pathological expression of Tau and transactive response DNA-binding protein 43 (TDP-43), two major hallmarks of AD, remains elusive. Here, increasin
Externí odkaz:
https://doaj.org/article/6b73d577d3e0465cb2b9994de6cdbdae
Autor:
Nunzio Vicario, Federica M. Spitale, Daniele Tibullo, Cesarina Giallongo, Angela M. Amorini, Grazia Scandura, Graziana Spoto, Miriam W. Saab, Simona D’Aprile, Cristiana Alberghina, Renata Mangione, Joshua D. Bernstock, Cirino Botta, Massimo Gulisano, Emanuele Buratti, Giampiero Leanza, Robert Zorec, Michele Vecchio, Michelino Di Rosa, Giovanni Li Volti, Giuseppe Lazzarino, Rosalba Parenti, Rosario Gulino
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-13 (2021)
Abstract Motoneuronal loss is the main feature of amyotrophic lateral sclerosis, although pathogenesis is extremely complex involving both neural and muscle cells. In order to translationally engage the sonic hedgehog pathway, which is a promising ta
Externí odkaz:
https://doaj.org/article/2f7b2c74627f4e859b99f24865313a4e
Autor:
Giovanna Calabrese, Raffaella Giuffrida, Stefano Forte, Claudia Fabbi, Elisa Figallo, Lucia Salvatorelli, Lorenzo Memeo, Rosalba Parenti, Massimo Gulisano, Rosario Gulino
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Traumatic injury or surgical excision of diseased bone tissue usually require the reconstruction of large bone defects unable to heal spontaneously, especially in older individuals. This is a big challenge requiring the development of biomat
Externí odkaz:
https://doaj.org/article/4418df1642d049ec91d58dffe3cbc75f
Severe loss of cholinergic neurons in the basal forebrain nuclei and of noradrenergic neurons in the locus coeruleus are almost invariant histopathological hallmarks of Alzheimer’s disease. However, the role of these transmitter systems in the spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4de48573f9abb4fa6dc39b375b61df3
https://hdl.handle.net/20.500.11769/552065
https://hdl.handle.net/20.500.11769/552065
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
In the past, manipulation of the cholinergic system was seen as the most likely therapeutic for neurodegeneration-based cognitive decline in Alzheimer's disease (AD) (Whitehouse et al., 1982). However, targeting the noradrenergic system also seems a
Externí odkaz:
https://doaj.org/article/1a67e83e865b41439f1c0736a0565b64
Autor:
Nunzio Vicario, Agata Zappalà, Giovanna Calabrese, Rosario Gulino, Carmela Parenti, Massimo Gulisano, Rosalba Parenti
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Cell-to-cell interaction and cell-to-extracellular environment communication are emerging as new therapeutic targets in neurodegenerative disorders. Dynamic expression of connexins leads to distinctive hemichannels and gap junctions, characterized by
Externí odkaz:
https://doaj.org/article/2f73e979a3bb4fe2be098ebefaa3f578
Autor:
Giovanna Calabrese, Rosario Gulino, Raffaella Giuffrida, Stefano Forte, Elisa Figallo, Claudia Fabbi, Lucia Salvatorelli, Lorenzo Memeo, Massimo Gulisano, Rosalba Parenti
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Injured articular cartilage has a limited innate regenerative capacity, due to the avascular nature and low cellularity of the tissue itself. Although several approaches have been proposed to repair the joint cartilage, none of them has proven to be
Externí odkaz:
https://doaj.org/article/0bfd7fd3c3634a40ad6d2c1c1c91e3eb
Autor:
Rosario Gulino, Domenico Nunziata, Gioacchino de Leo, Anna Kostenko, Serena Alexa Emmi, Giampiero Leanza
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5613
Loss of noradrenaline (NA)-rich afferents from the Locus Coeruleus (LC) ascending to the hippocampal formation has been reported to dramatically affect distinct aspects of cognitive function, in addition to reducing the proliferation of neural progen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb11f3c16f732bc00e6896fa8af7db9
https://doi.org/10.3390/ijms24065613
https://doi.org/10.3390/ijms24065613
Autor:
Rosario Gulino
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Retrogradely transported toxins are widely used to set up protocols for selective lesioning of the nervous system. These methods could be collectively named “molecular neurosurgery” because they are able to destroy specific types of neurons by us
Externí odkaz:
https://doaj.org/article/64da947c793244babb8aa3f62425ba81
Autor:
Giovanna Calabrese, Raffaella Giuffrida, Claudia Fabbi, Elisa Figallo, Debora Lo Furno, Rosario Gulino, Cristina Colarossi, Francesco Fullone, Rosario Giuffrida, Rosalba Parenti, Lorenzo Memeo, Stefano Forte
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151181 (2016)
Mesenchymal stem cells (MSCs) play a crucial role in regulating normal skeletal homeostasis and, in case of injury, in bone healing and reestablishment of skeletal integrity. Recent scientific literature is focused on the development of bone regenera
Externí odkaz:
https://doaj.org/article/ffb594e669014fc287f1a051febf40b2