Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Rosario Amato"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Myelofibrosis (MF) is a complex myeloproliferative neoplasm characterized by abnormal hematopoietic stem cell proliferation and subsequent bone marrow (BM) fibrosis. First documented in the late 19th century, MF has since been extensively st
Externí odkaz:
https://doaj.org/article/b3fd08c1e5694a448164f5ef797abca5
Autor:
Alessio Canovai, James R. Tribble, Melissa Jöe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte, Pete A. Williams
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-23 (2023)
Abstract Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range. Imbalances in metabolism and mitochondrial mechanisms can be sufficient to
Externí odkaz:
https://doaj.org/article/9b0fb1fc29404f1ebda176ae9e7a591f
Autor:
Veronica Rodriguez Fernandez, Rosario Amato, Simona Piaggi, Barbara Pinto, Giovanni Casini, Fabrizio Bruschi
Publikováno v:
Pathogens, Vol 13, Iss 8, p 701 (2024)
Ocular toxoplasmosis is the most prevalent clinical manifestation of T. gondii infection, which causes irreversible retinal damage. Different experimental models have been developed to study this pathology. In the present study, a new, ex vivo model
Externí odkaz:
https://doaj.org/article/e0dde58c4d1747319da8e8777b565c58
Autor:
Alberto Melecchi, Rosario Amato, Massimo Dal Monte, Dario Rusciano, Paola Bagnoli, Maurizio Cammalleri
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionMuch interest has been addressed to antioxidant dietary supplements that are known to lower the risk of developing glaucoma or delay its progression. Among them, niacin and citicoline protect retinal ganglion cells (RGCs) from degeneratio
Externí odkaz:
https://doaj.org/article/efe3fbfdd5f44d749632d04b2ca4c0f0
Autor:
Carolina Brescia, Vincenzo Dattilo, Lucia D’Antona, Emanuela Chiarella, Rossana Tallerico, Salvatore Audia, Valentina Rocca, Rodolfo Iuliano, Francesco Trapasso, Nicola Perrotti, Rosario Amato
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The Th17+ arrangement is critical for orchestrating both innate and acquired immune responses. In this context, the serum and glucocorticoid regulated kinase 1 (SGK1) exerts a key role in the governance of IL-23R-dependent Th17+ maturation, through t
Externí odkaz:
https://doaj.org/article/7f096d7da09943c9bf2415dd907f4548
Publikováno v:
Pharmacological Research, Vol 190, Iss , Pp 106713- (2023)
In the retina, hypoxic condition leads to overgrowing leaky vessels resulting in altered metabolic supply that may cause impaired visual function. Hypoxia-inducible factor-1 (HIF-1) is a central regulator of the retinal response to hypoxia by activat
Externí odkaz:
https://doaj.org/article/800e08a52f0644f793005cdde2fef478
Autor:
Rosario Amato, Alberto Melecchi, Laura Pucci, Alessio Canovai, Silvia Marracci, Maurizio Cammalleri, Massimo Dal Monte, Carla Caddeo, Giovanni Casini
Publikováno v:
Cells, Vol 12, Iss 20, p 2448 (2023)
Nutraceuticals are natural substances whose anti-oxidant and anti-inflammatory properties may be used to treat retinal pathologies. Their efficacy is limited by poor bioavailability, which could be improved using nanocarriers. Lisosan G (LG), a ferme
Externí odkaz:
https://doaj.org/article/6fc08fd7fae04cfc87e666eed49e529b
Autor:
Francesca Lazzara, Rosario Amato, Chiara Bianca Maria Platania, Federica Conti, Tsung-Han Chou, Vittorio Porciatti, Filippo Drago, Claudio Bucolo
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
Abstract Background Glaucoma is an optic neuropathy characterized by loss of function and death of retinal ganglion cells (RGCs), leading to irreversible vision loss. Neuroinflammation is recognized as one of the causes of glaucoma, and currently no
Externí odkaz:
https://doaj.org/article/3202a9e91f6d47d38eaeab8ead9c05ee
Autor:
Alberto Melecchi, Rosario Amato, Dominga Lapi, Massimo Dal Monte, Dario Rusciano, Paola Bagnoli, Maurizio Cammalleri
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Age-related macular degeneration (AMD) is nowadays considered among the retinal diseases whose clinical management lacks established treatment approaches, mainly for its atrophic (dry) form. In this respect, the use of dietary patterns enriched in om
Externí odkaz:
https://doaj.org/article/c3a713847ad04710908355b50c959d80
Publikováno v:
Cells, Vol 12, Iss 9, p 1272 (2023)
Glaucoma is a chronic optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) and the resulting mechanical stress are classically considered the main causes of RGC death. Howeve
Externí odkaz:
https://doaj.org/article/f9f17adc37f5417ea402593b53f4c925