Výsledky vyhledávání - "Rosaria De Santis"

Akademický článek

Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria

Autor: Larry J. Dishaw, Brittany Leigh, John P. Cannon, Assunta Liberti, M. Gail Mueller, Diana P. Skapura, Charlotte R. Karrer, Maria R. Pinto, Rosaria De Santis, Gary W. Litman

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)

Protochordates, including Ciona intestinalis, lack an adaptive immune system but possess innate immune receptors, including the secreted immunoglobulin V-region-containing VCBPs. Here the authors show that VCBP-C of Cionabinds gut bacteria and chitin

Externí odkaz: https://doaj.org/article/7e1d848d9d37487ca67bad82f4ee9607

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Akademický článek

Chitin protects the gut epithelial barrier in a protochordate model of DSS-induced colitis

Autor: Assunta Liberti, Ivana Zucchetti, Daniela Melillo, Diana Skapura, Yoshimi Shibata, Rosaria De Santis, Maria Rosaria Pinto, Gary W. Litman, Larry J. Dishaw

Publikováno v: Biology Open, Vol 7, Iss 1 (2018)

The gastrointestinal tract of Ciona intestinalis, a solitary tunicate that siphon-filters water, shares similarities with its mammalian counterpart. The Ciona gut exhibits other features that are unique to protochordates, including certain immune mol

Externí odkaz: https://doaj.org/article/54aacadf38e4403ab77ca4eca18e5df3

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Akademický článek

The gut of geographically disparate Ciona intestinalis harbors a core microbiota.

Autor: Larry J Dishaw, Jaime Flores-Torres, Simon Lax, Kristina Gemayel, Brittany Leigh, Daniela Melillo, M Gail Mueller, Lenina Natale, Ivana Zucchetti, Rosaria De Santis, Maria Rosaria Pinto, Gary W Litman, Jack A Gilbert

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93386 (2014)

It is now widely understood that all animals engage in complex interactions with bacteria (or microbes) throughout their various life stages. This ancient exchange can involve cooperation and has resulted in a wide range of evolved host-microbial int

Externí odkaz: https://doaj.org/article/2e7f829354cf4a47a1f695b97c7efc86

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Akademický článek

Expression of Ciona intestinalis variable region-containing chitin-binding proteins during development of the gastrointestinal tract and their role in host-microbe interactions.

Autor: Assunta Liberti, Daniela Melillo, Ivana Zucchetti, Lenina Natale, Larry J Dishaw, Gary W Litman, Rosaria De Santis, Maria Rosaria Pinto

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e94984 (2014)

Variable region-containing chitin-binding proteins (VCBPs) are secreted, immune-type molecules that have been described in both amphioxus, a cephalochordate, and sea squirt, Ciona intestinalis, a urochordate. In adult Ciona, VCBP-A, -B and -C are exp

Externí odkaz: https://doaj.org/article/bd5998fe27a042baa921e84457b8f282

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The EJC component Magoh in non-vertebrate chordates

Autor: Salvatore D'Aniello, Raffaella Tarallo, Jung Hee Levialdi Ghiron, Paolo Sordino, Luigi Caputi, Fabio Crocetta, Rosaria De Santis, Rosa Maria Sepe, Ivana Zucchetti

Publikováno v: Development Genes and Evolution. 230:295-304

Earliest craniates possess a newly enlarged, elaborated forebrain with new cell types and neuronal networks. A key question in vertebrate evolution is when and how this cerebral expansion took place. The exon-junction complex (EJC) plays an essential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f1716ed65a91b5f750f375ec238f09
https://doi.org/10.1007/s00427-020-00664-7

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Chitin protects gut epithelial barrier in a protochordate model of DSS-induced colitis

Autor: Ivana Zucchetti, Rosaria De Santis, Assunta Liberti, Maria Rosaria Pinto, Diana Skapura, Larry J. Dishaw, Yoshimi Shibata, Daniela Melillo, Gary W. Litman

Publikováno v: Biology open 7 (2018). doi:10.1242/bio.029355
info:cnr-pdr/source/autori:Liberti, Assunta; Zucchetti, Ivana; Melillo, Daniela; Skapura, Diana; Shibata, Yoshimi; De Santis, Rosaria; Pinto, Maria Rosaria; Litman, Gary W.; Dishaw, Larry J./titolo:Chitin protects the gut epithelial barrier in a protochordate model of DSS-induced colitis/doi:10.1242%2Fbio.029355/rivista:Biology open/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:7
Biology Open
Biology Open, Vol 7, Iss 1 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0af3cd73079f2c0f5ed80fae82eec9b
https://doi.org/10.1242/bio.029355

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Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria

Autor: M. Gail Mueller, Larry J. Dishaw, Rosaria De Santis, Gary W. Litman, Charlotte R. Karrer, Diana Skapura, John P. Cannon, Assunta Liberti, Brittany Leigh, Maria Rosaria Pinto

Publikováno v: Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)

Protochordate variable region-containing chitin-binding proteins (VCBPs) consist of immunoglobulin-type V domains and a chitin-binding domain (CBD). VCBP V domains facilitate phagocytosis of bacteria by granulocytic amoebocytes; the function of the C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4758716d35f17d8feaf767b447e6ec11
http://europepmc.org/articles/PMC4757023

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A role for variable region-containing chitin-binding proteins (VCBPs) in host gut–bacteria interactions

Autor: Daniela Melillo, Robert N. Haire, Gary W. Litman, Ivana Zucchetti, Rosaria De Santis, Maria Rosaria Pinto, Stefano Giacomelli, Lenina Natale, Larry J. Dishaw, Nicola Antonino Russo

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 108 (2011): 16747–16752. doi:10.1073/pnas.1109687108
info:cnr-pdr/source/autori:Dishaw, Larry J.; Giacomelli, Stefano; Melillo, Daniela; Zucchetti, Ivana; Haire, Robert N.; Natale, Lenina; Russo, Nicola A.; De Santis, Rosaria; Litman, Gary W.; Pinto, Maria Rosaria/titolo:A role for variable region-containing chitin-binding proteins (VCBPs) in host gut-bacteria interactions/doi:10.1073%2Fpnas.1109687108/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2011/pagina_da:16747/pagina_a:16752/intervallo_pagine:16747–16752/volume:108

A number of different classes of molecules function as structural matrices for effecting innate and adaptive immunity. The most extensively characterized mediators of adaptive immunity are the immunoglobulins and T-cell antigen receptors found in jaw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa75c2062ee5eb81edb2419d4afedb4e
https://doi.org/10.1073/pnas.1109687108

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ciCD94-1, an ascidian multipurpose C-type lectin-like receptor expressed in Ciona intestinalis hemocytes and larval neural structures

Autor: Maria Rosaria Pinto, Louis Du Pasquier, Rita Marino, John D. Lambris, Ivana Zucchetti, Rosaria De Santis

Publikováno v: Differentiation. 76:267-282

C-type lectins play an important role in the immune system and are part of a large superfamily that includes C-type lectin-like domain (CTLD)-containing proteins. Divergent evolution, acting on the CTLD fold, has generated the Ca 21 -dependent carboh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a425ed9149e97c778273a8aef3bf399c
https://doi.org/10.1111/j.1432-0436.2007.00214.x

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Ammonium channel expression is essential for brain development and function in the larva ofCiona intestinalis

Autor: Rita Marino, Miriam Di Filippo, Rosaria De Santis, Maria Rosaria Pinto, Euan R. Brown, Giorgio Matassi, Atsuko Yamada, Daniela Melillo

Publikováno v: Journal of comparative neurology (1911) 503 (2007): 135–147. doi:10.1002/cne.21370
info:cnr-pdr/source/autori:Marino, Rita; Melillo, Daniela; Di Filippo, Miriam; Yamada, Atsuko; Pinto, Maria Rosaria; De Santis, Rosaria; Brown, Euan R.; Matassi, Giorgio/titolo:Ammonium channel expression is essential for brain development and function in the larva of Ciona intestinalis/doi:10.1002%2Fcne.21370/rivista:Journal of comparative neurology (1911)/anno:2007/pagina_da:135/pagina_a:147/intervallo_pagine:135–147/volume:503

Ammonium uptake into the cell is known to be mediated by ammonium transport (Amt) proteins, which are present in all domains of life. The physiological role of Amt proteins remains elusive; indeed, loss-of-function experiments suggested that Amt prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1868db8774723950cb755be835c99bcf
https://doi.org/10.1002/cne.21370

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