Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Rosaria, Volpini"'
Autor:
Sara Calenda, Daniela Catarzi, Flavia Varano, Erica Vigiani, Rosaria Volpini, Catia Lambertucci, Andrea Spinaci, Letizia Trevisan, Ilenia Grieco, Stephanie Federico, Giampiero Spalluto, Gianluca Novello, Veronica Salmaso, Stefano Moro, Vittoria Colotta
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 468 (2024)
Protein kinase CK1δ (CK1δ) is a serine-threonine/kinase that modulates different physiological processes, including the cell cycle, DNA repair, and apoptosis. CK1δ overexpression, and the consequent hyperphosphorylation of specific proteins, can l
Externí odkaz:
https://doaj.org/article/b944e2eddc9841ab94df3e8bb3daf1fb
Autor:
Beatrice Francucci, Simone Angeloni, Diego Dal Ben, Catia Lambertucci, Massimo Ricciutelli, Andrea Spinaci, Aleksei Smirnov, Rosaria Volpini, Michela Buccioni, Gabriella Marucci
Publikováno v:
Molecules, Vol 28, Iss 12, p 4762 (2023)
Currently, the number of patients with neurodegenerative pathologies is estimated at over one million, with consequences also on the economic level. Several factors contribute to their development, including overexpression of A2A adenosine receptors
Externí odkaz:
https://doaj.org/article/0eb3a01762e042419555173ff01b8bcb
Autor:
Andrea Spinaci, Michela Buccioni, Daniela Catarzi, Chang Cui, Vittoria Colotta, Diego Dal Ben, Eleonora Cescon, Beatrice Francucci, Ilenia Grieco, Catia Lambertucci, Gabriella Marucci, Davide Bassani, Matteo Pavan, Flavia Varano, Stephanie Federico, Giampiero Spalluto, Stefano Moro, Rosaria Volpini
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 167 (2023)
Based on a screening of a chemical library of A2A adenosine receptor (AR) antagonists, a series of di- and tri-substituted adenine derivatives were synthesized and tested for their ability to inhibit the activity of the enzyme casein kinase 1 delta (
Externí odkaz:
https://doaj.org/article/1f850dd815cb47c18c31a8c7ecb2492f
Autor:
Andrea Spinaci, Michela Buccioni, Diego Dal Ben, Gabriella Marucci, Rosaria Volpini, Catia Lambertucci
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/c67a43e4a702478cac46d3dbfebbf2bb
Autor:
Andrea Spinaci, Catia Lambertucci, Michela Buccioni, Diego Dal Ben, Claudia Graiff, Maria Cristina Barbalace, Silvana Hrelia, Cristina Angeloni, Seyed Khosrow Tayebati, Massimo Ubaldi, Alessio Masi, Karl-Norbert Klotz, Rosaria Volpini, Gabriella Marucci
Publikováno v:
Molecules, Vol 27, Iss 8, p 2386 (2022)
The A2A adenosine receptor (A2AAR) is one of the four subtypes activated by nucleoside adenosine, and the molecules able to selectively counteract its action are attractive tools for neurodegenerative disorders. In order to find novel A2AAR ligands,
Externí odkaz:
https://doaj.org/article/8f7e1f3a6a2f44a8853bfc137106b801
Autor:
Daniela Catarzi, Flavia Varano, Erica Vigiani, Sara Calenda, Fabrizio Melani, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Natascia Mennini, Giulia Nerli, Diego Dal Ben, Rosaria Volpini, Vittoria Colotta
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 478 (2022)
A new set of amino-3,5-dicyanopyridines was synthesized and biologically evaluated at the adenosine receptors (ARs). This chemical class is particularly versatile, as small structural modifications can influence not only affinity and selectivity, but
Externí odkaz:
https://doaj.org/article/2d4d17b2c4234db89836b4d36ba4b954
Autor:
Andrea Spinaci, Michela Buccioni, Diego Dal Ben, Federica Maggi, Gabriella Marucci, Beatrice Francucci, Giorgio Santoni, Catia Lambertucci, Rosaria Volpini
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 164 (2022)
The overexpression of the A3 adenosine receptor (AR) in a number of cancer cell types makes it an attractive target for tumor diagnosis and therapy. Hence, in the search for new A3AR ligands, a series of novel 2,N6-disubstituted adenosines (Ados) was
Externí odkaz:
https://doaj.org/article/3f4314c00fb541fa93a5e8daf41da736
Autor:
Mariachiara Zuccarini, Catia Lambertucci, Marzia Carluccio, Patricia Giuliani, Maurizio Ronci, Andrea Spinaci, Rosaria Volpini, Renata Ciccarelli, Patrizia Di Iorio
Publikováno v:
Cells, Vol 10, Iss 12, p 3560 (2021)
Adenosine A1 receptor (A1R) activation, stimulating lipogenesis and decreasing insulin resistance, could be useful for metabolic syndrome management in obese subjects. Since full A1R agonists induce harmful side-effects, while partial agonists show a
Externí odkaz:
https://doaj.org/article/eadce9d5aa25496ea2a74c68af0bc765
Autor:
Flavia Varano, Daniela Catarzi, Erica Vigiani, Diego Dal Ben, Michela Buccioni, Gabriella Marucci, Lorenzo Di Cesare Mannelli, Elena Lucarini, Carla Ghelardini, Rosaria Volpini, Vittoria Colotta
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 657 (2021)
New compounds with a 7-amino-2-arylmethyl-thiazolo[5,4-d]pyrimidine structure were synthesized and evaluated in vitro for their affinity and/or potency at the human (h) A1, hA2A, hA2B, and hA3 adenosine receptors (ARs). Several compounds (5, 8–10,
Externí odkaz:
https://doaj.org/article/321d30349f8c4c519878eee1561c7b9f
Publikováno v:
BioFactors. 48:1027-1035
Skin aging is a complex biological process. Skin aspect is considered as a sign of well-being and of beauty. In view of this, noninvasive and/or minimally invasive anti-aging strategies were developed. Adenosine, a well-known nucleoside, may play a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db33644ebf82c245e03695809de6473
https://doi.org/10.1002/biof.1881
https://doi.org/10.1002/biof.1881