Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rosanne M. Orr"'
Autor:
Jane Renshaw, Rosanne M. Orr, Michael I. Walton, Robert te Poele, Richard D. Williams, Edward V. Wancewicz, Brett P. Monia, Paul Workman, Kathryn Pritchard-Jones
Publikováno v:
Molecular Cancer Therapeutics. 3:1467-1484
Deregulated expression of the Wilms' tumor gene (WT1) has been implicated in the maintenance of a malignant phenotype in leukemias and a wide range of solid tumors through interference with normal signaling in differentiation and apoptotic pathways.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a91249f89601d4c8a31708a8866dc52
https://doi.org/10.1158/1535-7163.1467.3.11
https://doi.org/10.1158/1535-7163.1467.3.11
Autor:
Ian Judson, Finbarr E. Cotter, Phyllis M. Goddard, Bob Bryant, Florence I. Raynaud, Rosanne M. Orr, Terry Beck
Publikováno v:
Nucleosides and Nucleotides. 16:1699-1702
G3139, an 18mer phosphorothioate (S-labeled), was administered to mice by single i.v. bolus or continuous S.C. infusion. The latter schedule resulted in reduced liver metabolism and urinary excretion together with greater tissue accumulation, in part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0887443811992041f3d0a4ae5f38e29
https://doi.org/10.1080/07328319708006258
https://doi.org/10.1080/07328319708006258
Autor:
Ian Judson, M. Dizik, B. D. Brown, Demetrios Papahadjopoulos, M. C. Woodle, Rosanne M. Orr, S. K. Huang, Florence I. Raynaud, J. A. Jaeger, Olivier Meyer
Publikováno v:
Nucleosides and Nucleotides. 16:1731-1734
G3139, an 18mer phosphorothioate, down regulates BCL2 and is efficacious in human xenograft tumor models. Studies of pharmacokinetics, toxicology, and influence of formulations on the biological properties of G3139 in mice are described. Bioavailabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::877035c4daa686a497845f22ec2dac7e
https://doi.org/10.1080/07328319708006265
https://doi.org/10.1080/07328319708006265
Autor:
Jane, Renshaw, Rosanne M, Orr, Michael I, Walton, Robert, Te Poele, Richard D, Williams, Edward V, Wancewicz, Brett P, Monia, Paul, Workman, Kathryn, Pritchard-Jones
Publikováno v:
Molecular cancer therapeutics. 3(11)
Deregulated expression of the Wilms' tumor gene (WT1) has been implicated in the maintenance of a malignant phenotype in leukemias and a wide range of solid tumors through interference with normal signaling in differentiation and apoptotic pathways.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee3bd20271ca3b68f1a0e4b9978e2d12
https://pubmed.ncbi.nlm.nih.gov/15542786
https://pubmed.ncbi.nlm.nih.gov/15542786
Autor:
Rosanne M, Orr, F Andrew, Dorr
Publikováno v:
Methods in molecular medicine. 106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fcb1d558c4704e6fd156a78b6bd2780
https://pubmed.ncbi.nlm.nih.gov/15375314
https://pubmed.ncbi.nlm.nih.gov/15375314
Autor:
Barry A. Murrer, Lloyd R. Kelland, Giandomenico Christen M, Rosanne M. Orr, T. Cobbleigh, Mervyn Jones, Phyllis M. Goddard, Sarah E. Morgan, Ken R. Harrap, Michael J. Abrams
Publikováno v:
Advances in enzyme regulation. 31
In the search for a platinum complex capable of oral administration, the poor bioavailability of established drugs has been circumvented by the discovery of a novel class of platinum (IV) ammine/amine dicarboxylate dichlorides. These compounds, when
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69ba3ba20af4c80ce63f1cfb50e18c2
https://pubmed.ncbi.nlm.nih.gov/1877393
https://pubmed.ncbi.nlm.nih.gov/1877393
Autor:
R. L. Powles, Gordon A. Taylor, John A. Stock, Rosanne M. Orr, Lawrence Davies, Kenneth R. Harrap
Publikováno v:
Biochemical Pharmacology. 37:673-677
Dinucleotides of adenosine and thymidine in the ApnT series (n = 3,4,5 and 6) and their corresponding phosphonate analogues, where a methylene group replaces the oxygen between the alpha and beta phosphorus atoms adjacent to thymidine, have been eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d1135e05ed88a7308d858aae39d646
https://doi.org/10.1016/0006-2952(88)90141-4
https://doi.org/10.1016/0006-2952(88)90141-4