Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rosanne Dunn"'
Publikováno v:
Blood. 140:4211-4212
Autor:
Jessica Li, Nicole Haynes, Katherine Cummins, Kavitha Gowrishankar, Kenneth Micklewaithe, Halley Hilton, Rosanne Dunn, Jane Oliaro, Simon Harrison
Publikováno v:
Cancer Research. 83:4074-4074
Multiple myeloma (MM), the second most common blood cancer, is characterized by the accumulation of malignant plasma cells in the bone marrow. Chimeric Antigen Receptor (CAR)-T cell therapy has recently entered the standard of care for relapsed and r
Autor:
Kate Reed, Edmond J. Breen, Ben R. Herbert, Douglas H. Campbell, Parisa Asvadi, Michael Copeman, Rosanne Dunn, Patricia Walker, Andrew Spencer
Publikováno v:
Blood Cancer Journal, Vol 9, Iss 8, Pp 1-5 (2019)
Blood Cancer Journal
Blood Cancer Journal
Publikováno v:
Blood. 138:1595-1595
Introduction: The novel kappa (κ) myeloma antigen (KMA) has been described and a specific monoclonal antibody KappaMab (formerly MDX-1097) developed which is currently in a Phase IIb clinical trial. In this study 2 human LambdaMabs (10B3 and 7F11) w
Autor:
Flora Yuen, Anna Kalff, Hang Quach, Craig T. Wallington-Beddoe, Simon J. Harrison, John V. Reynolds, Jake Shortt, Rosanne Dunn, Patricia Walker, Andrew Spencer
Publikováno v:
Blood. 134:3144-3144
BACKGROUND: KappaMab is a chimeric IgG1 monoclonal antibody specific for Kappa Myeloma antigen (KMA), a tumour specific cell antigen exclusively expressed on the surface of kappa restricted MM cells. Early safety and efficacy signals seen with single
Abstract 3572: CAR T-cells targeting the kappa myeloma antigen for the treatment of multiple myeloma
Publikováno v:
Cancer Research. 78:3572-3572
This study describes the development of highly specific and effective CAR T-cells expressing novel Chimeric Antigen Receptors targeting the Kappa Myeloma Antigen. Multiple myeloma (MM) is an incurable malignancy of differentiated plasma cells accompa
Autor:
Andrew Spencer, Vivien Jiang, Andrew R. Cuddihy, Darren R. Jones, Rosanne Dunn, Parisa Asvadi, Tiffany Khong, Mae X Wong
Publikováno v:
British journal of haematology. 169(3)
MDX-1097 is an antibody specific for a unique B cell antigen called kappa myeloma antigen (KMA) that consists of cell membrane-associated free kappa light chain (κFLC). KMA was detected on kappa human multiple myeloma cell lines (κHMCLs), on plasma
Publikováno v:
Journal of Molecular Biology. 312:875-884
A phospholipase A 2 inhibitor has been identified in the serum of the common tiger snake ( Notechis scutatus ). The inhibitor is composed of two chains, an α-chain and a β-chain, that form a non-covalently associated complex capable of inhibiting t
Autor:
Kathryn M. Weston, Stuart G. Tangye, Alison Smith, Robert L. Raison, Michael B. Morris, Rosanne Dunn
Publikováno v:
Journal of Molecular Recognition. 14:245-253
Mouse immunoglobulin (Ig) molecules have previously been shown to bind to the surface of CD5(+) B cells from patients with B-cell chronic lymphocytic leukemia (B-CLL). The results indicated that surface IgM was involved in the interaction and suggest
Publikováno v:
Protein expression and purification. 24(3)
We have previously described the production of a recombinant melittin-based cytolytic immunotoxin (IT), scFv-mel-FLAG, in bacterial cells. While the IT exhibited specific cytotoxicity for a human lymphoblastoid cell line, HMy2, yields from expression