Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Rosannah Pearson"'
Autor:
Don O. Somers, Amanda J. Campbell, Dave Mallett, Rosannah Pearson, David D. Miller, Kenneth David Down, Steve Ludbrook, Maria Gerelle, Geoff W. Mellor, John A. Christopher, Yemisi E. Solanke, Keith P. Ray, Paul Bamborough, Catherine M. Alder
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3936-3940
A novel pyrrole-2-carboxamide series of p38α inhibitors, discovered through the application of virtual screening, is presented. Following evaluation of activity, selectivity and developability properties of commercially available analogues, a synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685f09a34eb6c6406209700b29cb445e
https://doi.org/10.1016/j.bmcl.2010.05.011
https://doi.org/10.1016/j.bmcl.2010.05.011
Autor:
Penny A. Smee, Stephen Sean Flack, Steve Ludbrook, Ann Louise Walker, Timothy Longstaff, Mark James Bamford, Paul Bamborough, Katherine Louise Jones, Chun-wa Chung, Rosannah Pearson, Tony D. Angell, Dramane I. Laine, Stuart G. Cockerill, Smith Kathryn Jane, Richard Martyn Angell, Don O. Somers
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(15)
The biphenyl amides (BPAs) are a series of p38alpha MAP kinase inhibitors. Compounds are able to bind to the kinase in either the DFG-in or DFG-out conformation, depending on substituents. X-ray, binding, kinetic and cellular data are shown, providin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ab7c9ac6f3d7bf78d18847b8283213
https://pubmed.ncbi.nlm.nih.gov/18602262
https://pubmed.ncbi.nlm.nih.gov/18602262