Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Rosanna Maccari"'
Autor:
Rosaria Ottanà, Paolo Paoli, Mario Cappiello, Trung Ngoc Nguyen, Ilenia Adornato, Antonella Del Corso, Massimo Genovese, Ilaria Nesi, Roberta Moschini, Alexandra Naß, Gerhard Wolber, Rosanna Maccari
Publikováno v:
Molecules, Vol 26, Iss 2, p 330 (2021)
Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and is one of the leading cause of death worldwide. Its development implies numerous metabolic dysfunctions and the onset of hyperglycaemia-induced chron
Externí odkaz:
https://doaj.org/article/5dbb82913dc34a5d862083d04bc41b3c
Autor:
Rosanna Maccari, Rosaria Ottanà
Publikováno v:
Journal of Medicinal Chemistry. 65:10848-10881
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors (gliflozins) represent the most recently approved class of oral antidiabetic drugs. SGLT-2 overexpression in diabetic patients contributes significantly to hyperglycemia and related complications. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f925d2b585c2199f11c8b3521b24d35
https://doi.org/10.1021/acs.jmedchem.2c00867
https://doi.org/10.1021/acs.jmedchem.2c00867
Autor:
Rosanna Maccari, Gerhard Wolber, Massimo Genovese, Gemma Sardelli, Valerij Talagayev, Francesco Balestri, Simone Luti, Alice Santi, Roberta Moschini, Antonella Del Corso, Paolo Paoli, Rosaria Ottanà
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0e5d5c5747c011e3887d62be1d8222
https://doi.org/10.2139/ssrn.4345262
https://doi.org/10.2139/ssrn.4345262
Autor:
Alexandra Naß, Paolo De Paoli, Mario Cappiello, Rosanna Maccari, Francesco Balestri, Gerhard Wolber, Antonella Del Corso, Giulia Lori, Ilenia Adornato, Rosaria Ottanà
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3712-3720
Designed multiple ligands (DMLs), developed to modulate simultaneously a number of selected targets involved in etiopathogenetic mechanisms of a multifactorial disease, such as diabetes mellitus (DM), are considered a promising alternative to combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6073126821f647fa6752075bff55109a
https://doi.org/10.1016/j.bmcl.2018.10.024
https://doi.org/10.1016/j.bmcl.2018.10.024
Autor:
Gerhard Wolber, Adriana Carol Eleonora Graziano, Ilenia Adornato, Venera Cardile, Rosaria Ottanà, Rosanna Maccari, Archimede Rotondo, Paolo De Paoli, Alexandra Naß, Giulia Lori
Publikováno v:
European Journal of Medicinal Chemistry. 127:840-858
New 4-{[5-arylidene-2-(4-fluorophenylimino)-4-oxothiazolidin-3-yl]methyl}benzoic acids (5) and 2-thioxo-4-thiazolidinone analogues (6) were synthesised as a part of a continuing search for new inhibitors of protein tyrosine phosphatase 1B (PTP1B), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2d387709e583003f800ea08f959cae
https://doi.org/10.1016/j.ejmech.2016.10.063
https://doi.org/10.1016/j.ejmech.2016.10.063
Autor:
Ilenia Adornato, Rosanna Maccari, Paolo De Paoli, Giulia Lori, Alexandra Naß, Gerhard Wolber, Santo Previti, Rosaria Ottanà
Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin and leptin signalling and is crucially involved in the development of type 2 diabetes mellitus, obesity, cancer and neurodegenerative diseases. Pursuing our efforts to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da24b8595996831c82c38e4f536a33b
http://hdl.handle.net/2158/1171692
http://hdl.handle.net/2158/1171692
Autor:
Roberta Moschini, Ilaria Nesi, Trung Ngoc Nguyen, Antonella Del Corso, Rosanna Maccari, Massimo Genovese, Paolo De Paoli, Ilenia Adornato, Gerhard Wolber, Rosaria Ottanà, Mario Cappiello, Alexandra Naß
Publikováno v:
Molecules
Volume 26
Issue 2
Molecules, Vol 26, Iss 330, p 330 (2021)
Volume 26
Issue 2
Molecules, Vol 26, Iss 330, p 330 (2021)
Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and is one of the leading cause of death worldwide. Its development implies numerous metabolic dysfunctions and the onset of hyperglycaemia-induced chron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc68d1010cf1de2f7cbda56990a5249
https://doi.org/10.3390/molecules26020330
https://doi.org/10.3390/molecules26020330
Publikováno v:
Carbohydrate Research. 499:108220
Diabetes mellitus is a multifactorial disease, which is frequently complicated by the development of hyperglycaemia-induced chronic complications. The therapy of diabetes mellitus often requires combinations of two or more drugs in order both to cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b800f9013ac2f2664cd025566711f0b
https://doi.org/10.1016/j.carres.2020.108220
https://doi.org/10.1016/j.carres.2020.108220
Autor:
Federica Mannino, Giuseppe Bruno, Rosaria Ottanà, Silvana Grasso, Santo Previti, Francesco Nicolò, Alexandra Naß, Gerhard Wolber, Ilenia Adornato, Rosanna Maccari, Maria Zappalà, Alessandra Bitto, Roberta Ettari, Federica Aliquò
This paper describes the design, synthesis, and biological evaluation of 2-thioxoimidazolidin-4-one derivatives as inhibitors of proteasome and immunoproteasome, potential targets for the treatment of hematological malignancies. In particular, we foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a500e1d8c94be2e46c34801803054e7
http://hdl.handle.net/11570/3119303
http://hdl.handle.net/11570/3119303
Autor:
Zhuanghong Qiao, Rosanna Maccari, Mahzad Akbarpour, Rosaria Ottanà, David Gozal, Abdelnaby Khalyfa
Study objectives Sleep fragmentation (SF) is highly prevalent and has emerged as an important contributing factor to obesity and metabolic syndrome. We hypothesized that SF-induced increases in protein tyrosine phosphatase-1B (PTP-1B) expression and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fae8d82e53d07d10b6067ee24a761a
http://hdl.handle.net/11570/3132071
http://hdl.handle.net/11570/3132071